Human GPD1 / GPD-C Protein
- Known as:
- Human GPD1 / GPD-C Protein
- Catalog number:
- GP1-H5148
- Product Quantity:
- 1mg
- Category:
- -
- Supplier:
- acrobyosystems
- Gene target:
- Human GPD1 / GPD- Protein
Related genes to: Human GPD1 / GPD-C Protein
- Gene:
- ACKR1 NIH gene
- Name:
- atypical chemokine receptor 1 (Duffy blood group)
- Previous symbol:
- FY, DARC
- Synonyms:
- CCBP1, GPD, Dfy, CD234
- Chromosome:
- 1q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
- Gene:
- GPD1 NIH gene
- Name:
- glycerol-3-phosphate dehydrogenase 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2015-11-05
Related products to: Human GPD1 / GPD-C Protein
Related articles to: Human GPD1 / GPD-C Protein
- Aconitine (AC) ranks among the leading causes of fatal herbal poisoning globally due to its narrow therapeutic window. Although its cardiovascular toxicity has been extensively studied, the precise molecular mechanisms underlying AC-induced central nervous system damage remain unclear. This study aimed to investigate the role of glycerol-3-phosphate dehydrogenase 1 (GPD1) in AC-induced neurotoxicity and to elucidate the underlying metabolic and molecular mechanisms. In a rat model of acute AC poisoning, significant neurological impairments, anxiety-like behaviors, and neuron-specific cell death were observed. Transcriptomic analyses revealed marked metabolic reprogramming following AC exposure, characterized by upregulation of GPD1 and suppression of the peroxisome proliferator-activated receptor gamma (PPARĪ³) signaling pathway. Mechanistically, AC disrupted GPD1/PPARĪ³ signaling homeostasis, leading to pathological lipid droplet accumulation and mitochondrial dysfunction, as evidenced by loss of membrane potential and ATP depletion, ultimately resulting in neuronal apoptosis. Notably, targeted knockdown of Gpd1 using shRNA alleviated lipid accumulation, restored mitochondrial function, and significantly improved survival rates and neurological outcomes in poisoned rats. These findings identify the aconitine-GPD1-lipid/mitochondrial axis as a key mechanism underlying AC-induced neurotoxicity and suggest GPD1 as a potential therapeutic target. - Source: PubMed
Publication date: 2026/04/29
Jiang ChenHu WenDeng SangyangHuang YongjieWang LinboYang ZhenyuLi YufeiLi PingWu Haiying - - Source: PubMed
Publication date: 2026/04/30
Das SamannayBiswas Tamoghna - Osteoporosis is the leading cause of fractures, characterized by reduced bone formation and increased bone resorption. Exploring the potential mechanisms of antidiabetic drugs in the treatment of OP provides valuable clinical insights for the future pharmacological management of osteoporosis patients. - Source: PubMed
Publication date: 2026/04/21
Jing Yu-LongZhu Xiao-YangGong Shen-AoSun TaoLin Xiao-Yan - Mutations in the gene, which encodes glycerol-3-phosphate dehydrogenase 1 (GPD1), are a rare cause of monogenic hypertriglyceridemia (HTG) during childhood. This study is aimed at providing a detailed analysis of the clinical, laboratory, and molecular characteristics of all patients affected by biallelic gene variants, including three cases from our center. - Source: PubMed
Publication date: 2026/04/09
Alharbi MoodhiAlasmari AliAlkasim SultanAl-Hussaini Abdulrahman - Head and neck squamous cell carcinoma (HNSCC) remains a lethal malignancy with its pathogenic mechanisms incompletely unraveled. This study interrogates the role of the HDAC2-GPD1 axis in driving HNSCC progression. - Source: PubMed
Publication date: 2026/04/08
Xue LiqiongTang WenboZhou MingwangLing QinZhou Jiuli