Human CD47 Protein
- Known as:
- Human CD47 Protein
- Catalog number:
- CD7-H5227
- Product Quantity:
- 1mg
- Category:
- -
- Supplier:
- acrobyosystems
- Gene target:
- Human CD47 Protein
Related genes to: Human CD47 Protein
- Gene:
- CD47 NIH gene
- Name:
- CD47 molecule
- Previous symbol:
- MER6
- Synonyms:
- IAP, OA3
- Chromosome:
- 3q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-12
- Date modifiied:
- 2016-10-05
Related products to: Human CD47 Protein
Related articles to: Human CD47 Protein
- Tumor cells utilize metabolic reprogramming to obtain the energy required for rapid proliferation. In this study, we blocked two key factors, hypoxia-inducible factor 1-alpha (HIF-1α) and lactate dehydrogenase (LDHA), in the metabolic pathway in acute myeloid leukemia (AML) cell lines to evaluate their effect on the expression of genes involved in tumor evasion. - Source: PubMed
Publication date: 2026/01/01
Eskandari TamanaShams MehrshadKhanari AliKahrizi AmirAsgarian-Omran HosseinValadan RezaTehrani MohsenTaghiloo Saeid - Tumor-associated macrophages (TAM) exert essential functions during the immune response to cancer. However, investigations of TAM within a native human tumor microenvironment (TME) have been impeded by a lack of appropriate model systems. Here, patient-derived organoids (PDO) from air-liquid interface (ALI)-grown tumor fragments, containing a human TME that encompassed stroma and immune subsets, robustly preserved TAM that were maintained by endogenous CSF-1 and appropriately responded to polarization signals. Antibody blockade of the CD47 regulatory checkpoint in organoids stimulated phagocytosis and remodeled TAM cytokine secretion profiles that were confirmed in anti-CD47 phase I trial patients. Amongst PDO histologies screened, anti-CD47 tumor killing was notable in clear cell renal cell carcinoma (ccRCC) which was associated with increased TAM infiltration. PDO contained diverse previously described TAM subsets; however, anti-CD47 reprogrammed organoid TAM toward an immunosuppressive SPP1+ phenotype, highlighting a negative feedback mechanism. Our findings uncover a resistance circuit engaged by macrophage checkpoint blockade and position ALI PDO as a robust translational platform for dissecting human macrophage biology and informing precision immunotherapy. - Source: PubMed
Publication date: 2026/05/09
Nakano MichitakaHeo LyongYang Yu-PingMunoz Lorena PLiu YihuaZhao LeiPark JuhyungTsekitsidou EiriniFrancois AnthonyLiu JieTrotman-Grant Aaron CEcheverri Maria Fernanda HenaoRada Cara CTran EdwardKhokhar AryaYuki KanakoBhattacharya AsmitaHorn Hudson TPolak RoelYenwongfai Leonard NLi YingPeach MattNasajpour EmonPavlovitch-Bedzyk Ana JimenaChang Anne Lynn SLim MichaelPetritsch Claudia KGephart Melanie HaydenLeppert John TNair Ramesh VDavis Mark MBassik Michael CZhang MelodyOdegard JaredBates Jamie GLeung Lawrence L KMajeti RavindraKuo Calvin J - Red blood cells (RBCs), formerly viewed as mere oxygen transporters, are now acknowledged as dynamic biological entities with intricate molecular characteristics which impact their deformability, lifespan, and interactions within the vascular system. Progress in molecular hematology has elucidated how modifications in RBC proteins, lipids, ion channels, and adhesion molecules influence physiological adaptability, pathogenic mechanisms, and transfusion results. Inherited and acquired illnesses, such as sickle cell disease, thalassemia, malaria, human immunodeficiency virus (HIV), and metabolic disorders, highlight how alterations in membrane structure, phospholipid asymmetry, and signaling pathways exacerbate hemolysis, restrict circulation, and provoke inflammation or thrombosis. Geographic and environmental pressures, such as hypoxia at elevated altitudes, emphasize the variety of molecular methods that facilitate oxygen delivery. The integration of these insights into clinical practice reveals that molecular markers such as Band 3, PIEZO1, ICAM-4, CD36, and CD47 are becoming significant diagnostic and prognostic instruments, while targeted therapies focusing on ion channels, oxidative pathways, and adhesion molecules are creating new therapeutic possibilities. These results highlight that RBC molecular profiling is enhancing our comprehension of erythrocyte biology while also transforming diagnostics, transfusion medicine, and customized therapy in hematology. - Source: PubMed
Publication date: 2026/04/30
Almadhaani Khawla YousifAltaie Alaa MuayadHamoudi Rifat - Ki-67, a canonical proliferation marker, represents a pivotal prognostic and predictive biomarker in breast cancer. Here, by profiling 88,208 single-cell transcriptomes of circulating tumor cells (CTCs) matched with primary and metastatic lesions in breast cancer mouse models, we uncover a striking enrichment of cell-cycle genes in CTCs, particularly in CTC clusters. Using in vivo CRISPR screens, we identify Ki-67 as an essential regulator of CTC intravasation, whose knockout reduces metastasis. Mechanistically, Ki-67 depletion does not curb proliferation but suppresses genes involved in maintaining cell-cell adhesion, including CD47 and KLF4, thereby linking its expression to collective invasion dynamics. Altogether, decoupling it from its role as a proliferation marker, our findings uncover an unexpected function of Ki-67 as a molecular driver of metastatic competence. - Source: PubMed
Publication date: 2026/05/15
Zhang YongzhanZhou JianwenStrittmatter KarinZhang Yu WeiWaldmeier MariaAsawa SimranVujanovic MarkoBudinjas SelinaSaini MassimoIldiz Ece SuGvozdenovic AnaKovacs WernerCastro-Giner FrancescAceto Nicola - Lactobacillus SlpX protein has been identified as a surface-layer protein (SLP) with the function of mediating intestinal colonization of the strain, but the mechanism of its action on intestinal immunomodulation has not yet been elucidated. In this study, we investigated the protective function of SlpX protein on the intestinal epithelial cell barrier by constructing cellular models, molecular docking and molecular dynamics simulations. - Source: PubMed
Publication date: 2026/05/14
Zhu YeyingCao YingyingFan XiankangWu ZhenShi ZihangZhang TaoCai ZhendongZeng XiaoqunPan Daodong