human CD74 / DHLAG Protein
- Known as:
- H. sapiens CD74 / DHLAG Protein
- Catalog number:
- CD4-H524c
- Product Quantity:
- 1mg
- Category:
- -
- Supplier:
- acrobyosystems
- Gene target:
- human CD74 / DHLAG Protein
Related genes to: human CD74 / DHLAG Protein
- Gene:
- CD74 NIH gene
- Name:
- CD74 molecule
- Previous symbol:
- DHLAG
- Synonyms:
- -
- Chromosome:
- 5q33.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: human CD74 / DHLAG Protein
Related articles to: human CD74 / DHLAG Protein
- Atherosclerosis is a leading cause of global morbidity and mortality. Cholesterol crystal embolism (CCE) in advanced atherosclerosis can lead to acute kidney injury (AKI) through ischemic cortical necrosis. However, a single-cell atlas of the CCE kidney remains incomplete, impeding rational therapeutic design. In a C57BL/6J mouse CCE model generated by unilateral renal artery CC injection, single-cell transcriptomics revealed widespread changes across 17 kidney cell types. The differentially expressed genes (DEGs) varied markedly, with 1659 in the ascending loop of Henle and 1505 in proximal tubules, whereas only 7 were in dendritic cells. Cell-cell interaction analyses revealed a central role for C-C motif chemokine ligand (CCL)-C-C motif chemokine receptor 5 (CCR5) and macrophage migration inhibitory factor (MIF)-cluster of differentiation 74 (CD74) pathways in CCE formation and related outcomes, including vascular injury, AKI, and immune cell infiltration. Human kidney biopsies from patients with CCE showed CD74-positive staining near obstructed arteries with cholesterol clefts. Pharmacological inhibition of CCR5 or CD74 using maraviroc or milatuzumab, respectively, as well as their combined administration before CC injection, reduced vascular thrombosis and tissue damage without raising bleeding risk in the C57BL/6J mouse CCE model. Even when treatment was delayed by 2 hours postembolism, it still decreased complications like thrombotic angiopathy and AKI upon CCE. These findings highlight CCR5 and CD74 as potential therapeutic targets for CCE-related necroinflammation. - Source: PubMed
Publication date: 2026/05/27
Shi ChongxuWen ZhaozhiZheng KoulongLi BowenMiao HuipingKlinkhammer Barbara MBoor PeterAnders Hans-JoachimLiu Dong - Tumor-associated macrophages (TAMs) are key components of the hepatocellular carcinoma (HCC) microenvironment, but their spatial heterogeneity remains incompletely characterized. We aimed to assess the biological and prognostic relevance of a -associated TAM program in HCC. Public single-cell RNA sequencing (scRNA-seq) datasets were analyzed to characterize TAM heterogeneity, and an integrated validation scRNA-seq dataset was used to assess reproducibility. Spatial transcriptomics was used to provide spatial context in a small treatment-exposed cohort. Pseudotime, regulatory network, and cell-cell communication analyses were performed to characterize state transitions and microenvironmental interactions. Survival modeling evaluated the prognostic relevance of the -associated program. Five TAM subsets were identified, including MARCO, MT RTM-, MMP9, UBE2C, and BAG3 TAMs. Among them, BAG3 TAMs, a less well-characterized subset, exhibited coordinated stress-adaptive, proteostasis-related, and matrix-remodeling programs that were reproduced in the validation dataset. Pseudotime analysis suggested a continuum of TAM states, with BAG3 TAM stress-remodeling features enriched toward late pseudotime. Communication analysis centered on BAG3 TAMs suggested crosstalk between inflammatory stress cues and angiogenic, stromal-remodeling, and immunomodulatory programs; this pattern was primarily supported by HBV-derived samples and recurrently involved the MIF-CD74 axis. Spatial mapping further supported BAG3 TAM-enriched niches with elevated AP-1, EGR1, and NFKB1 activity. A -associated risk score derived from a 10-gene signature remained an independent prognostic factor for overall survival after clinical adjustment. These findings characterize a -associated TAM program with spatial, immunoregulatory, and prognostic relevance in HCC, and support its further evaluation in biomarker and mechanistic studies. - Source: PubMed
Publication date: 2026/05/11
Zhang RuixiangWei YifangYu JundaLi YuanshengYou ZumingXie ChenxiXu SiqiZhou Jiyuan - Emerging evidence highlights the importance of the MIF-sCD74 axis in health and disease, including its role in regulating cell death. While studies in routine cardiac surgery suggest perioperative relevance, its role in end-stage heart failure (ESFH) patients undergoing left ventricular assist device (LVAD) implantation remains unexplored. Moreover, although MIF and sCD74 induce necroptosis in neonatal cardiac myofibroblasts, the effects of MIF, its paralog D-DT, and sCD74 on adult cardiac myofibroblasts (CMFs) are unknown. Plasma concentrations of sCD74, MIF and D-DT were measured perioperatively in a small cohort of patients with ESHF undergoing LVAD implantation (n = 20). As a preclinical model of ESHF, primary adult CMFs were treated with recombinant MIF, D-DT and sCD74 to evaluate their effects on cellular viability and health. In LVAD patients, sCD74 and D-DT levels were significantly increased 24 h postoperatively, whereas MIF levels were reduced compared to baseline. ROC curve analysis demonstrated a good discriminatory power of 24 h post-OP sCD74 (AUC = 0.83), sCD74/MIF ratio (AUC = 0.82), and D-DT levels (AUC = 0.88) for acute kidney injury, composite outcome, and right heart failure (RHF), respectively. In adult CMFs, MIF and sCD74 synergistically reduced viable cell counts ( = 0.0083), whereas D-DT reduced cell counts in an sCD74-independent manner ( = 0.0004). Yet, measures of metabolism, proliferation, apoptosis and necrosis along with inflammatory gene expression remained unchanged. Our findings indicate that the balance of MIF, D-DT, and sCD74 during LVAD implantation may be clinically relevant. In particular, an imbalance characterized by elevated sCD74 or D-DT and reduced MIF levels 24 h post-surgery was associated with unfavorable clinical outcomes. Yet, the current findings are exploratory and hypothesis-generating because of a small sample size. Thus, the prognostic value of plasma levels for postoperative complications after LVAD implantation, and the effects of MIF/D-DT/sCD74 imbalance on cardiac myofibroblasts, need to be validated in larger cohorts and in advanced human experimental models. - Source: PubMed
Publication date: 2026/04/30
Kunze MaximUhlig MoritzTheißen AlexanderStoppe ChristianBeckers ChristianLarmann JanZayat RachadMoza AjayBernhagen JürgenGoetzenich AndreasBleilevens ChristianSoppert Josefin - Inflammatory monocyte (MC) subset polarization is a hallmark of systemic and tissue inflammatory feature in diabetes. The underlying molecular mechanism remains unclear. - Source: PubMed
Publication date: 2026/05/08
Yang PingpingFang PuSun LizheLiu LuFu LinghuaXi HangWang XianweiBouchareb RihabZhang DaqingWu QinghuaJi YongYang XiaofengWang Hong - Osteosarcoma (OS) is a common primary malignant bone tumor in children and adolescents. Increasing evidence suggests that immune dysregulation contributes to OS progression, but its tissue-level and systemic features remain incompletely defined. This study aimed to characterize immune-related alterations in OS and identify key immunoregulatory molecules associated with disease progression. - Source: PubMed
Publication date: 2026/05/07
Zhu JichongHuang ChengqianTan Weiming