Human Adiponectin / ADIPOQ Protein
- Known as:
- Human Adiponectin / ADIPOQ Protein
- Catalog number:
- ADQ-H5229
- Product Quantity:
- 1mg
- Category:
- -
- Supplier:
- acrobyosystems
- Gene target:
- Human Adiponectin / ADIPOQ Protein
Related genes to: Human Adiponectin / ADIPOQ Protein
- Gene:
- ADIPOQ NIH gene
- Name:
- adiponectin, C1Q and collagen domain containing
- Previous symbol:
- ACDC
- Synonyms:
- ACRP30, AdipoQ, apM1, GBP28, adiponectin
- Chromosome:
- 3q27.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-26
- Date modifiied:
- 2016-10-05
Related products to: Human Adiponectin / ADIPOQ Protein
Related articles to: Human Adiponectin / ADIPOQ Protein
- Adiponectin dysregulation has been implicated in Alzheimer's disease (AD), but the respective roles of total and high-molecular-weight (HMW) adiponectin, as well as central versus peripheral mechanisms, remain unclear. We aimed to investigate the association between biomarker-confirmed AD and plasma total adiponectin, HMW/total adiponectin ratio, and CSF/plasma adiponectin ratio, used as an indirect marker of central-peripheral distribution. We also assessed correlations with CSF amyloid and tau biomarkers. In this monocentric cross-sectional study, 134 participants (90 AD, 44 controls) from a tertiary memory clinic were included. Plasma and CSF total adiponectin were measured by ELISA, and plasma HMW adiponectin by chemiluminescent immunoassay. Associations were analyzed using multivariate linear regression adjusted for age, sex, body mass index, and APOE ε4 carriership. Plasma total and HMW adiponectin levels were higher in AD than in controls (p < 0.05 and p < 0.005, respectively), but the association was no longer significant after adjustment. The HMW/total ratio was higher in AD (0.50 vs. 0.43, p = 0.02), whereas the CSF/plasma ratio did not differ between groups (p = 0.69). No correlations were found between adiponectin (plasma total and HMW, and CSF total) and CSF amyloid or tau biomarkers. Although adiponectin levels were elevated in biomarker-confirmed AD, this association was largely driven by age, sex, and BMI. Overall, adiponectin appears to reflect systemic metabolic and nutritional status rather than AD-specific pathophysiology. - Source: PubMed
Publication date: 2026/06/26
Sindzingre LouiseDecaix ThéodoreGotze KarlBaratelli PaulBailly MarieMouton-Liger FrançoisCognat EmmanuelDumurgier JulienVrillon AgatheCecon ErikaPaquet ClaireLilamand MatthieuBouaziz-Amar Elodie - To identify proteomic signatures underlying 3-year progression from impaired fasting glucose (IFG) to diabetes. - Source: PubMed
Publication date: 2026/06/25
Rooney Mary REchouffo Tcheugui Justin BChen JingshaWalker Keenan ABallantyne Christie MBoerwinkle EricKelly Tanika NNdumele Chiadi EPankow James SGrams Morgan EPost Wendy SGanz Peter JWood Alexis CRotter Jerome ISelvin ElizabethCoresh Josef - BackgroundChronic inflammation from visceral obesity contributes to metabolic disorders and cancer through cytokine imbalance. Accurate cytokine measurement is crucial to understand these links. This study examined challenges in quantifying interleudin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), leptin, and adiponectin in historical biobank samples with limited volumes and varying plasma anticoagulants.MethodsLuminex-MAGPIX platform was used to evaluate three analytical aspects. Single-well precision was assessed via intra- and inter-assay coefficients of variability (CVs). Plasma matrix effects were examined by pairwise comparison of analyte concentrations across citrate, heparin, and EDTA plasma from 10 volunteers. Cytokine stability was tested after one freeze-thaw cycle (analysis of variance).ResultsSingle-well measurements showed good precision (CV <10% intra-assay, <15% inter-assay). Plasma matrix affected absolute concentrations. In particular, all analytes were lower in citrate than in EDTA and heparin, but relative relationships and subject-specific rankings remained preserved. Pearson correlation coefficients for IL-6, leptin, and adiponectin were high across matrices (r-range = 0.952-0.999), whereas correlations for TNF-α were lower (r-range = 0.897-0.972). Freeze-thaw stability was analyte- and matrix-dependent: leptin remained stable in heparin and EDTA but decreased 9.5% in citrate; adiponectin was stable in citrate but decreased in heparin (-9.0%) and EDTA (-11.8%). IL-6 and TNF-α were unaffected.ConclusionIL-6, TNF-α, leptin, and adiponectin were accurately quantified using single-well Luminex assays and showed reasonable tolerance to a single freeze-thaw cycle, offering a practical strategy for preserving valuable specimens. Although plasma anticoagulant affected absolute concentrations, the preservation of relative analyte rankings permits their use in most study designs but limit absolute value comparisons. - Source: PubMed
Publication date: 2026/06/24
Pattaroni LaraVenturelli ElisabettaMorelli DanieleBianchi MichelaGuerra GiuliaSegrado FrancescoSieri SabinaPolymeropoulos AlessioAgnoli Claudia - Adipose tissue is not only the primary site of energy storage but also an essential metabolic organ for maintaining energy homeostasis to regulate adipogenesis, metabolism, and chronic inflammation in mammals. However, the cross-species conservation and divergence of its cellular composition and transcriptional features remain unclear. To address this, we analyzed single-cell RNA sequencing datasets from cattle, pigs, and humans. Conserved cell types, including adipocytes, adipose stem and progenitor cells (ASPCs), macrophages, endothelial cells, and T cells, were identified across all three species. In contrast, pigs uniquely contained mesenchymal cells (COL1A1, COL1A2) and B cells (CD37), cattle possessed distinct preadipocyte populations (COL3A1, PNPLA2, GPAM), and humans exhibited abundant dendritic (HLA-DRA, HLA-DRB1) and mast cells (KIT). Focusing on adipocytes, we identified 537, 160, and 73 species-specific DEGs in cattle, pigs, and humans, respectively. Gene Ontology enrichment analysis of adipocyte-specific DEGs revealed that genes enriched in cattle were primarily involved in cytoskeletal organization and triglyceride biosynthesis (LPIN1, DGAT2), those enriched in pigs in oxidative phosphorylation and thermogenesis (LIPE, CIDEA), and those enriched in humans in lipid transport and immune signaling (ADIPOQ, LPL). Overall, this study establishes a cross-species single-cell atlas of subcutaneous adipose tissue, providing insights into conserved architectures and species-specific adaptations, and serving as a valuable resource for comparative biology and livestock research. - Source: PubMed
Niu XinranZhai LiweiWang LuluWang JiahaoZheng ZhuoyeYang JinyanWang XiniLiu JianfengXing KaiWang Chuduan - Metabolic dysfunctions are associated with increased cancer morbidity and rapid tumor progression. The alpha1-oleate complex has been used successfully to treat bladder cancer in a placebo-controlled Phase II study. Studies of the related BAMLET complexes recently identified effects on metabolism, suggesting additional functions of the "HAMLET family" of tumoricidal complexes. - Source: PubMed
Publication date: 2026/06/23
Haq FarhanChinchankar SiddharthAmbite InesAhmadi ShahramTran HienNazari AtefehBrisuda AntoninHacek JaromirBabjuk MarekSvanborg Catharina