Human 2B4 / CD244 / SLAMF4 Protein
- Known as:
- Human 2B4 / CD244 / SLAMF4 Protein
- Catalog number:
- 2B4-H5224
- Product Quantity:
- 1mg
- Category:
- -
- Supplier:
- acrobyosystems
- Gene target:
- Human 2B4 / CD244 SLAMF4 Protein
Related genes to: Human 2B4 / CD244 / SLAMF4 Protein
- Gene:
- CD244 NIH gene
- Name:
- CD244 molecule
- Previous symbol:
- -
- Synonyms:
- 2B4, NAIL, NKR2B4, Nmrk, SLAMF4
- Chromosome:
- 1q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-23
- Date modifiied:
- 2016-10-05
- Gene:
- GSTT1-AS1 NIH gene
- Name:
- GSTT1 antisense RNA 1
- Previous symbol:
- -
- Synonyms:
- lncRNA-AS-GSTT1(1-72), lncRNA-CD244, lncRNA-BC050410
- Chromosome:
- 22q11.23 alternate reference locus
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2015-08-05
- Date modifiied:
- 2015-08-05
Related products to: Human 2B4 / CD244 / SLAMF4 Protein
Related articles to: Human 2B4 / CD244 / SLAMF4 Protein
- Multiple sclerosis (MS) is a progressive chronic autoimmune-mediated disease. Recently, long non-coding RNAs (lncRNAs) are characterized to participate in the adjustment of immune responses. Here, we evaluated the expression levels of GSTT1-AS1 and IFNG-AS1 lncRNAs and their targets (TNF and IFNG, respectively) in Iranian MS patients.In this case-control study, 50 relapsing-remitting MS patients and 50 healthy subjects were recruited. Expressions of GSTT1-AS1 and IFNG-AS1 lncRNAs, as well as TNF and IFNG genes, were assessed in their peripheral blood samples by SYBR Green-based Real-time quantitative PCR.Expression levels of GSTT1-AS1 and IFNG-AS1 lncRNAs were both significantly downregulated (p values 0.032 and 0.013, respectively). On the other hand, the expression of TNF and IFNG showed increased levels, however, did not reach statistical significance after our analysis (p > 0.05). Spearman correlation analysis showed that GSTT1-AS1 had a significant positive moderate correlation with IFNG-AS1 (r = 0.541, p < 0.0001), IFNG (r = 0.329, p = 0.001), and TNF (r = 0.204, p = 0.041). Also, IFNG-AS1 revealed the same correlation with IFNG (r = 0.475, p < 0.0001) as well as TNF (r = 0.399, p < 0.0001). Furthermore, GSTT1-AS1 (r = 0.313, p = 0.027) and (IFNG r = 0.478, p < 0.0001) demonstrated a significant positive correlation with age at onset.Briefly, the current study provided for the first time dysregulation of GSTT1-AS1 and IFNG-AS lncRNAs network in MS, which highlights the significant role of epigenetic pathways in this autoimmune disorder. Larger sample size and further investigation assays could shed light on the underlying mechanisms in this area of science. - Source: PubMed
Publication date: 2019/01/24
Ganji MaziarSayad ArezouOmrani Mir DavoodArsang-Jang ShahramMazdeh MehrdokhtTaheri Mohammad