MMP16 IHC Antibody
- Known as:
- MMP16 Immunohistochemistry Antibody
- Catalog number:
- IW-PA1123
- Product Quantity:
- 1
- Category:
- -
- Supplier:
- IHC
- Gene target:
- MMP16 IHC Antibody
Related genes to: MMP16 IHC Antibody
- Gene:
- MMP16 NIH gene
- Name:
- matrix metallopeptidase 16
- Previous symbol:
- C8orf57
- Synonyms:
- MT3-MMP, DKFZp761D112
- Chromosome:
- 8q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-11-13
- Date modifiied:
- 2016-10-05
Related products to: MMP16 IHC Antibody
Related articles to: MMP16 IHC Antibody
- As anthropogenic habitat fragmentation and population decline accelerate globally, growing numbers of species face compounding demographic and genetic threats to long-term survival. Many populations are already forced to persist at chronically small sizes, yet the genomic and fitness consequences of this fate remain poorly understood. Here we leverage the demographic history of the Devils Hole pupfish to investigate how long-term small population size and recent bottlenecks have shaped genetic diversity, genetic load, inbreeding, and fitness through comparative population genomics, historical sequencing, and sampling embryos that died prematurely during development. We find that genetic diversity in Devils Hole pupfish is among the lowest recorded in the wild and that fixed load is high, consistent with thousands of generations of isolation at small population size. Even in the face of this low diversity and high fixed load, we show that inbreeding is still strongly associated with premature embryonic death, which affects up to 25% of offspring in the captive refuge and can be identified in advance based on a characteristic elongated heart tube and reduced heart rate. We discovered a recessive lethal haplotype segregating at ~20% frequency that accounts for 50% of embryonic deaths and contains mutations in MIB1 and MMP16, genes associated with cardiomyopathy and atrial fibrillation. Our findings link genotype, phenotype, and fitness in an iconic endangered species to provide a rare comprehensive view into the evolutionary dynamics and consequences of long-term small effective population size, demonstrating that endangered species remain vulnerable to inbreeding depression despite extremely low genetic diversity. - Source: PubMed
Publication date: 2026/06/10
Tian DavidAlexandre NicolasSiu NaomiMuhl VanessaLema Sean CTurner Bruce JFeuerbacher OlinWilson KevinSchwemm MichaelMoorjani PriyaGumm JenniferMartin Christopher Herbert - Cell fate determination and terminal differentiation are shaped by intrinsic molecular programs that coordinate lineage-specific gene expression. In mesenchymal stem cells (MSCs), variability in osteogenic efficiency among distinct tissue sources remains poorly understood and cannot be fully explained by differentiation conditions alone. Increasing evidence indicates that post-transcriptional regulatory mechanisms, particularly those mediated by microRNAs (miRNAs), are closely associated with differentiation outcomes. Here, we investigated whether intrinsic miRNA expression landscapes are associated with lineage-associated differences in late-stage mineralization, in the context of potential donor-related variability of human MSCs. Dental pulp stem cells (DPSCs) and processed lipoaspirate (PLA)-derived MSCs were cultured under identical osteogenic induction conditions and analyzed longitudinally throughout differentiation. Both cell populations fulfilled established mesenchymal phenotypic criteria and successfully initiated osteogenic commitment. However, DPSCs exhibited significantly enhanced extracellular matrix mineralization at mid-to-late stages of differentiation, suggesting divergence at later stages of extracellular matrix mineralization rather than at early lineage commitment. Temporal small RNA sequencing performed at days 0, 7, 14, and 21 revealed progressive remodeling of miRNA expression in both MSC sources. Direct comparison at the mature osteoblast stage identified a discrete set of ten miRNAs differentially expressed between DPSCs and PLA-derived cells. DPSCs displayed reduced expression of several miRNAs previously associated with inhibitory roles in osteogenic pathways. Network-based analyses indicated convergence of these miRNAs on gene programs involved in skeletal development and extracellular matrix organization. Targeted validation confirmed decreased expression of miR-10a-5p and miR-196a-5p, accompanied by increased expression of osteogenesis-associated genes, including BMP1 and MMP16, in DPSCs. Collectively, these findings show that lineage-specific miRNA expression patterns are associated with distinct osteogenic maturation trajectories in human MSCs. This work identifies an intrinsic post-transcriptional signature through which cellular origin may influence terminal differentiation outcomes and suggests that such miRNA profiles may serve as informative molecular biomarkers in the future for the selection and characterization of mesenchymal stem cells intended for human bone tissue engineering applications. - Source: PubMed
Publication date: 2026/03/22
Pinheiro Carla Cristina GLopes-Ramos Camila MInagaki TaroAsprino Paula FontesFerreira José Ricardo Mde Mattos Ygor Gonçalves FélixCampos Helena Coutinho GeigerShibli Jamil AwardParmigiani Raphael BJarrahy RezaHokugo AkishigeFaria Alessandra V SBueno Daniela Franco - We performed proteome-wide Mendelian randomization (MR) and colocalization analyses to explore the causal relationships between proteins and schizophrenia (SCZ). - Source: PubMed
Publication date: 2026/02/27
Lin JingyuHuang HaimingChen LinWei YanyanSi TianmeiSu YunaiNiu YajuanChen Jingxu - Xin'anjiang water buffalo (XAJB) is crucial for meat production and agricultural activities in Anhui Province of China. To generate hypotheses regarding how DNA methylation might correlate with transcriptional differences in skeletal muscle, WGBS and RNA-seq were performed on three BF and three BM adult XAJB. The results revealed 31,333 differentially methylated cytosines (DMCs), 1961 differentially methylated regions (DMRs), and 230 differentially expressed genes (DEGs) in skeletal muscle between the two groups. The qRT-PCR results of ten DEGs (, , , , , , , , and ) enriched in protein digestion and absorption pathway, PPAR signaling pathway, ECM-receptor interaction pathway or PI3K-Akt signaling pathway were consistent with the RNA-seq results. Most methylation changes occurred in CG context, and sixteen genes were predicted as dual differential genes in both methylation and transcriptome. Moreover, CG methylation showed a significant negative correlation with gene expression within the 2 kb upstream region (rho = -0.42, < 0.001). Given the limited number of animals examined, additional investigations with expanded cohorts are essential to verify the association between the methylome and transcriptome signatures underlying skeletal muscle in XAJB. - Source: PubMed
Publication date: 2026/02/10
Zhao ShuanpingJin HaiLiu JunLi YongshengLi QianZhang HuibinDu XinyiLi QinggangXu Lei - Gastric cancer (GC) is the fifth most common type worldwide, representing a public health problem. Among the genes related to this tumorigenesis, the family of matrix metalloproteinases (MMPs), essential regulators of the extracellular matrix (ECM), stand out for their involvement in the development and progression of GC. Therefore, we aimed to evaluate MMP gene expression variation, its relationship with clinicopathological factors and its transcriptome-wide associations. To this end, RNAseq, correlation network, and biological pathway enrichment analyses were performed on tumor samples from GC and peritumoral samples from patients treated at a reference center in the Northern region of Brazil. Among the 22 investigated MMPs, seven genes (MMP2, MMP3, MMP10, MMP12, MMP14, MMP15, and MMP16) were upregulated in cancer, while MMP8 was downregulated. Increased expression of seven of the eight differentially expressed MMPs was found in early stages of the disease compared to Tumor, Node, Metastasis (TNM) stage IV. MMP16 showed higher expression in the diffuse-type gastric adenocarcinoma. An increased expression of MMP10 was observed in the EBV/TCGA group. A significant reduction in survival was noticed in those patients with lower expression of MMP8, MMP12, and MMP14. Transcriptomic correlation analyses demonstrated that differentially expressed MMPs interact with genes likely involved in cell adhesion, ECM organization, and immune response, such as COL1A2, CDH11, KIRREL1, PPP1R14D, CEACAM8, ZNF423, and PRRX1. The enrichment of biological pathways suggests involvement in processes such as ECM organization, collagen and proteoglycan degradation, suggesting that these genes possibly are involved in carcinogenic dynamics, supporting the role of MMPs in tumor ECM reorganization. - Source: PubMed
Publication date: 2026/02/23
Bastos Aline CostaKhayat André SalimMoraes Emanuele Raimunda LouzadaTavares Ágatha Tereza MirandaMourão Ronald Matheus da SilvaMoreira Fabiano CordeiroCasseb Samir Mansour MoraesDemachki SamiaIshak GeraldoBarra Williams FernandesBurbano Rommel Mario Rodríguezde Assumpção Paulo Pimentel