MMP16 IHC Antibody
- Known as:
- MMP16 Immunohistochemistry Antibody
- Catalog number:
- IW-PA1123
- Product Quantity:
- 1
- Category:
- -
- Supplier:
- IHC
- Gene target:
- MMP16 IHC Antibody
Related genes to: MMP16 IHC Antibody
- Gene:
- MMP16 NIH gene
- Name:
- matrix metallopeptidase 16
- Previous symbol:
- C8orf57
- Synonyms:
- MT3-MMP, DKFZp761D112
- Chromosome:
- 8q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-11-13
- Date modifiied:
- 2016-10-05
Related products to: MMP16 IHC Antibody
Related articles to: MMP16 IHC Antibody
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Chen GuohaoGao XianDai LingchenDeng ShukangWang HaoyangHuang XinkunFeng Ying - Anthracyclines are a widely used and effective class of chemotherapy. However, a major limitation for their use is cardiotoxicity, manifesting as systolic dysfunction, congestive heart failure, and arrhythmias. The objective of this study was to identify genes and genetic risk variants for doxorubicin-induced arrhythmia. - Source: PubMed
Publication date: 2026/07/29
Reddy Joseph SPereyra MilagrosAbbas Mohammed TiseerArsanjani RezaPrah Isaac EBoddicker Nicholas JCerhan James RLarson Melissa CRaphael MwangiHabermann Thomas MVillarraga Hector RVierkant Robert ALuehrs Tony CSicotte HuguesEgan Jan BLazaridis Konstantinos NMoossavi MaryamXu XiaoleiAdvani Pooja PAyoub ChadiNorton Nadine - As anthropogenic habitat fragmentation and population decline accelerate globally, growing numbers of species face compounding demographic and genetic threats to long-term survival. Many populations are already forced to persist at chronically small sizes, yet the genomic and fitness consequences of this fate remain poorly understood. Here we leverage the demographic history of the Devils Hole pupfish to investigate how long-term small population size and recent bottlenecks have shaped genetic diversity, genetic load, inbreeding, and fitness through comparative population genomics, historical sequencing, and sampling embryos that died prematurely during development. We find that genetic diversity in Devils Hole pupfish is among the lowest recorded in the wild and that fixed load is high, consistent with thousands of generations of isolation at small population size. Even in the face of this low diversity and high fixed load, we show that inbreeding is still strongly associated with premature embryonic death, which affects up to 25% of offspring in the captive refuge and can be identified in advance based on a characteristic elongated heart tube and reduced heart rate. We discovered a recessive lethal haplotype segregating at ~20% frequency that accounts for 50% of embryonic deaths and contains mutations in MIB1 and MMP16, genes associated with cardiomyopathy and atrial fibrillation. Our findings link genotype, phenotype, and fitness in an iconic endangered species to provide a rare comprehensive view into the evolutionary dynamics and consequences of long-term small effective population size, demonstrating that endangered species remain vulnerable to inbreeding depression despite extremely low genetic diversity. - Source: PubMed
Publication date: 2026/06/10
Tian DavidAlexandre NicolasSiu NaomiMuhl VanessaLema Sean CTurner Bruce JFeuerbacher OlinWilson KevinSchwemm MichaelMoorjani PriyaGumm JenniferMartin Christopher Herbert - Cell fate determination and terminal differentiation are shaped by intrinsic molecular programs that coordinate lineage-specific gene expression. In mesenchymal stem cells (MSCs), variability in osteogenic efficiency among distinct tissue sources remains poorly understood and cannot be fully explained by differentiation conditions alone. Increasing evidence indicates that post-transcriptional regulatory mechanisms, particularly those mediated by microRNAs (miRNAs), are closely associated with differentiation outcomes. Here, we investigated whether intrinsic miRNA expression landscapes are associated with lineage-associated differences in late-stage mineralization, in the context of potential donor-related variability of human MSCs. Dental pulp stem cells (DPSCs) and processed lipoaspirate (PLA)-derived MSCs were cultured under identical osteogenic induction conditions and analyzed longitudinally throughout differentiation. Both cell populations fulfilled established mesenchymal phenotypic criteria and successfully initiated osteogenic commitment. However, DPSCs exhibited significantly enhanced extracellular matrix mineralization at mid-to-late stages of differentiation, suggesting divergence at later stages of extracellular matrix mineralization rather than at early lineage commitment. Temporal small RNA sequencing performed at days 0, 7, 14, and 21 revealed progressive remodeling of miRNA expression in both MSC sources. Direct comparison at the mature osteoblast stage identified a discrete set of ten miRNAs differentially expressed between DPSCs and PLA-derived cells. DPSCs displayed reduced expression of several miRNAs previously associated with inhibitory roles in osteogenic pathways. Network-based analyses indicated convergence of these miRNAs on gene programs involved in skeletal development and extracellular matrix organization. Targeted validation confirmed decreased expression of miR-10a-5p and miR-196a-5p, accompanied by increased expression of osteogenesis-associated genes, including BMP1 and MMP16, in DPSCs. Collectively, these findings show that lineage-specific miRNA expression patterns are associated with distinct osteogenic maturation trajectories in human MSCs. This work identifies an intrinsic post-transcriptional signature through which cellular origin may influence terminal differentiation outcomes and suggests that such miRNA profiles may serve as informative molecular biomarkers in the future for the selection and characterization of mesenchymal stem cells intended for human bone tissue engineering applications. - Source: PubMed
Publication date: 2026/03/22
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Publication date: 2026/02/27
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