FAS-L IHC Antibody
- Known as:
- Fas Cell Surface Death Receptor-L Immunohistochemistry Antibody
- Catalog number:
- IW-PA1101
- Product Quantity:
- 1
- Category:
- -
- Supplier:
- IHC
- Gene target:
- FAS- IHC Antibody
Related genes to: FAS-L IHC Antibody
- Gene:
- BDNF-AS NIH gene
- Name:
- BDNF antisense RNA
- Previous symbol:
- BDNFOS
- Synonyms:
- BT2A, BT2B, BT2C, BT2D, NCRNA00049, BDNF-AS1, BDNFAS
- Chromosome:
- 11p14.1
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2005-02-01
- Date modifiied:
- 2017-08-09
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
- Gene:
- FAS-AS1 NIH gene
- Name:
- FAS antisense RNA 1
- Previous symbol:
- FASAS, FAS-AS
- Synonyms:
- SAF
- Chromosome:
- 10q23.31
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2009-07-16
- Date modifiied:
- 2018-05-02
- Gene:
- FASN NIH gene
- Name:
- fatty acid synthase
- Previous symbol:
- -
- Synonyms:
- FAS, SDR27X1
- Chromosome:
- 17q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-05-17
- Date modifiied:
- 2016-10-05
- Gene:
- FASTK NIH gene
- Name:
- Fas activated serine/threonine kinase
- Previous symbol:
- -
- Synonyms:
- FAST
- Chromosome:
- 7q36.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-04-05
- Date modifiied:
- 2016-10-05
Related products to: FAS-L IHC Antibody
Related articles to: FAS-L IHC Antibody
- An increasing number of studies have demonstrated that excessive proliferation and apoptosis play a pivotal role in the development of endometriosis. - Source: PubMed
Publication date: 2024/12/23
Shayanfard Amir HosseinSalehi ZivarMashayekhi FarhadZahiri Ziba - Osteoarthritis (OA) is a prevalent degenerative disease. We explored the role and regulatory mechanisms of lncRNA-FAS-AS1 in OA progression. - Source: PubMed
Zhang ZhehuaMao HonggangLi FangWang DahaiLiu Yan - Vascular calcification is a frequently occurring complication of end-stage renal disease (ESRD). This study focused on the significance of long non-coding RNA Fas cell surface death receptor-antisense 1(lncRNA FAS-AS1) in ESRD-related vascular calcification aiming to explore a potential biomarker for the detection. - Source: PubMed
Publication date: 2023/11/25
Wu JiaqiWan MingJiang ZhaopengGong WushuangZhou Xianli - Nasopharyngeal carcinoma (NPC) is a common head and neck malignant with a high incidence in Southern China. Genetic aberrations play a vital role in the pathogenesis, progression and prognosis of NPC. In the present study, we elucidated the underlying mechanism of FAS-AS1 and its genetic variation rs6586163 in NPC. We demonstrated that FAS-AS1 rs6586163 variant genotype carriers were associated with lower risk of NPC (CC vs. AA, OR = 0.645, P = 0.006) and better overall survival (AC + CC vs. AA, HR = 0.667, P = 0.030). Mechanically, rs6586163 increased the transcriptional activity of FAS-AS1 and contributed to ectopic overexpression of FAS-AS1 in NPC. rs6586163 also exhibited an eQTL trait and the genes affected by rs6586163 were enriched in apoptosis related signaling pathway. FAS-AS1 was downregulated in NPC tissues and over-expression of FAS-AS1 was associated with early clinical stage and better short-term treatment efficacy for NPC patients. Overexpression of FAS-AS1 inhibited NPC cell viability and promoted cell apoptosis. GSEA analysis of RNA-seq data suggested FAS-AS1 participate in mitochondria regulation and mRNA alternative splicing. Transmission electron microscopic examination verified that the mitochondria was swelled, the mitochondrial cristae was fragmented or disappeared, and their structures were destroyed in FAS-AS1 overexpressed cells. Furthermore, we identified HSP90AA1, CS, BCL2L1, SOD2 and PPARGC1A as the top 5 hub genes of FAS-AS1 regulated genes involved in mitochondria function. We also proved FAS-AS1 could affect Fas splicing isoform sFas/mFas expression ratio, and apoptotic protein expression, thus leading to increased apoptosis. Our study provided the first evidence that FAS-AS1 and its genetic polymorphism rs6586163 triggered apoptosis in NPC, which might have a potential as new biomarkers for NPC susceptibility and prognosis. - Source: PubMed
Publication date: 2023/05/22
Guo ZhenLi ZiBoZhang MengLingBao MeiHuaHe BinShengZhou XiaoLong - Glioblastoma multiform (GBM) is an invasive cancer that causes high mortality in patients. Disruption of the apoptosis process is one of the main pathogenesis of the disease. Recently, LncRNAs and miRNAs have been shown to play an important role in the process of apoptosis. To follow the aim of study, 100 patients participated in the two groups of 50 individuals, including 50 GBM patients and 50 healthy individuals as the control group. Mononuclear cells were isolated from peripheral blood samples and RNA extraction was done. The expression changes of miR-17-5p, miR-20-5p, LINC01605, FAS-AS1, and Caspase 3 were examined using RT-PCR in both groups. Expression of LINC01605, miR-20-5p, and miR-17-5p increased in patients, while Caspase 3 and FAS-AS1 decreased; the difference was statistically significant between the two groups. In addition, it was found that these factors have the appropriate sensitivity and specificity as diagnostic markers. Finally, It is suggested to use the LINC01605, FAS-AS1, miR-20-5p, miR-17-5p, and Caspase 3 as apoptosis predictors in the GM patients. - Source: PubMed
Publication date: 2023/01/13
Haghighi Shirin SetoodehGhaderian Sayyed Mohammad HosseinRakhshan AzadehMotamed Nasrin