Human IP-10 (CXCL10)
- Known as:
- Human IP-10 (CXCL10)
- Catalog number:
- GEM-300-158P1
- Product Quantity:
- 1 mg
- Category:
- -
- Supplier:
- SeraLab
- Gene target:
- Human IP-10 (CXCL10)
Related genes to: Human IP-10 (CXCL10)
- Gene:
- BBIP1 NIH gene
- Name:
- BBSome interacting protein 1
- Previous symbol:
- NCRNA00081
- Synonyms:
- bA348N5.3, BBIP10, BBS18
- Chromosome:
- 10q25.2
- Locus Type:
- gene with protein product
- Date approved:
- 2008-09-02
- Date modifiied:
- 2016-10-05
- Gene:
- CXCL10 NIH gene
- Name:
- C-X-C motif chemokine ligand 10
- Previous symbol:
- INP10, SCYB10
- Synonyms:
- IFI10, IP-10, crg-2, mob-1, C7, gIP-10
- Chromosome:
- 4q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-09
- Date modifiied:
- 2016-10-05
- Gene:
- CXCR3 NIH gene
- Name:
- C-X-C motif chemokine receptor 3
- Previous symbol:
- GPR9
- Synonyms:
- CKR-L2, CMKAR3, IP10-R, MigR, CD183
- Chromosome:
- Xq13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-11-01
- Date modifiied:
- 2016-10-05
- Gene:
- MED24 NIH gene
- Name:
- mediator complex subunit 24
- Previous symbol:
- THRAP4, CRSP4
- Synonyms:
- TRAP100, KIAA0130, DRIP100, CRSP100, MED5
- Chromosome:
- 17q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-30
- Date modifiied:
- 2016-10-05
- Gene:
- PPIAP10 NIH gene
- Name:
- peptidylprolyl isomerase A pseudogene 10
- Previous symbol:
- PPIAL2, PPIP10
- Synonyms:
- CRP
- Chromosome:
- 20q13.2
- Locus Type:
- pseudogene
- Date approved:
- 1998-10-12
- Date modifiied:
- 2017-08-21
Related products to: Human IP-10 (CXCL10)
Related articles to: Human IP-10 (CXCL10)
- This study investigates the mediating role of inflammatory cytokines in the protective effect of human milk against bronchopulmonary dysplasia (BPD) in preterm infants. - Source: PubMed
Rao YunbeiWang XuanLi QinglingYang LinglingXiong XiaoyunHan DongshanYang ChuanzhongChen Xueyu - The complex interaction between the intestinal microbiota and host mucosal immunity plays a defining role in colorectal cancer (CRC) development and therapeutic outcomes. Recently, bacterial outer membrane vesicles (OMVs)-nano-sized, lipid-bilayered extracellular particulates released by both commensal and pathogenic microorganisms-have emerged as critical long-range signaling vehicles within the gut. This review provides a comprehensive synthesis of the dual functionalities of OMVs in CRC pathogenesis and oncology. Mechanistically, pathogenic OMVs cross compromised mucosal barriers to drive horizontal gene transfer (HGT) of chimeric episomes, such as SPHINX DNAs and Bovine Meat and Milk Factors (BMMFs), thereby promoting genomic instability and neoplastic transformation. Conversely, there is a paradigm shift toward exploiting next-generation probiotic and engineered OMVs as highly tunable therapeutic platforms. By combining cutting-edge bioengineering strategies-such as biomimetic mineralization to neutralize local tissue acidity and chemotherapeutic packaging-these nanovectors effectively reprogram the immunosuppressive tumor microenvironment (TME). Specifically, optimized OMVs modulate macrophage polarization from an M2 to an M1 phenotype and stimulate CXCL10-mediated CD8+ T-cell infiltration, effectively turning immunologically "cold" tumors "hot." Finally, the great translational challenges regarding systemic endotoxicity, scalability, and target delivery, providing a strategic approach for the integration of OMV-based platforms into synergistic immune checkpoint inhibition regimens. - Source: PubMed
Publication date: 2026/09/17
Khaneshi MarziehFaraji Akhijahani RoghayehMobayen GolnazShadravan SepidehLahouty Masoud - - Source: PubMed
Publication date: 2026/09/16
Cohen Naama TSchonmann YochaiCzarnowicki Tali - The early-life gut microbiome may influence susceptibility to antibody-mediated neonatal autoimmunity, but the underlying mechanisms remain poorly understood. We investigated whether gut microbial functional capacity and metabolites influence autoantibody-dependent immune activation in 90 neonates, including healthy controls, anti-Ro/La-exposed neonates without neonatal lupus erythematosus (No-NLE), and neonates with NLE ( = 30 per group). Shotgun metagenomic profiling demonstrated progressive remodeling of the neonatal gut microbiome across the three groups, with anti-Ro/La exposure associated with depletion of early-life commensal-associated taxa, including , , and , and enrichment of taxa with opportunistic potential, including and , with greatest ecological divergence in neonates with NLE. Functional profiling identified altered microbial carbohydrate-processing capacity, marked by enrichment of glycosyltransferase family 4 (GT4) and depletion of GT2 in NLE. These alterations coincided with broad reductions in plasma short-chain fatty acid metabolites, most prominently butyrate, together with increased serum immunoglobulin G (IgG) and interferon- (IFN-) and decreased complement component 4 (C4). A GT4---IFN- signature distinguished NLE from No-NLE (AUC = 0.883; 95% CI, 0.799-0.967). In functional assays, pooled bacteria-depleted fecal filtrates from neonates with NLE potentiated IFN- production by neonatal peripheral blood mononuclear cells in the presence of anti-Ro/La-positive plasma. Conversely, sodium butyrate suppressed anti-Ro/La-associated IFN- production and reduced 28 inflammation-related proteins, including CXCL10, ADA, and PD-L1, involved in cytokine, IL-17, and TNF signaling. Together, these findings provide functional evidence supporting a microbiota-associated butyrate-type I interferon pathway that may amplify maternal autoantibody-dependent immune activation and contribute to the clinical manifestation of NLE. - Source: PubMed
Publication date: 2026/09/16
Sun WenqiangLi YihuiLiu XueYu ShuyangLi WenmeiWang HuaweiGeng HaifengLi LiliHu JinhuiHuo JieZhang WanyanFu JingJin XinyunLi HengZhou XihuiZhu Xueping - Skin aging is a major consideration regarding cosmetic skin care. The cosmetic field is seeking new active ingredients able to slow down the appearance of signs of age. Some lichens and more specifically the genus . presents an interest as a source of active molecules because it is already being used in traditional and modern medicines. To better evaluate the potential of as anti-aging skin care, we investigated some key aspects to protect skin from external aggression and to avoid skin alteration, which would exacerbate signs of age. Among them, our results reveal (i) antioxidant capacities; (ii) anti-inflammatory properties on human keratinocytes once stimulated, as shown by a decrease in IL-6, IL-8, CXCL9, CXCL10, and CCL5; (iii) a downregulation of MT1-MMP, which corresponds to decreased tissue remodeling; and (iv) an inhibition of human tyrosinase, which could correct the appearance over time of age-related skin spots. Altogether, these results highlight the potential use of in anti-aging skin care. - Source: PubMed
Publication date: 2026/08/26
Groso AnthonyJabet PaulFan YangHua WangYawen HuMiao GuoDaniellou RichardCollet Guillaume