ADH1B Blocking Peptide, Blocking Peptides
- Known as:
- ADH1B Blocking Peptide, Blocking Peptides
- Catalog number:
- 33R-6775
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Fitzgerald
- Gene target:
- ADH1B Blocking Peptide Peptides
Related genes to: ADH1B Blocking Peptide, Blocking Peptides
- Gene:
- ADH1B NIH gene
- Name:
- alcohol dehydrogenase 1B (class I), beta polypeptide
- Previous symbol:
- ADH2
- Synonyms:
- -
- Chromosome:
- 4q23
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-01-18
Related products to: ADH1B Blocking Peptide, Blocking Peptides
Related articles to: ADH1B Blocking Peptide, Blocking Peptides
- Microcystin-LR (MC-LR), a hepatotoxic aquatic contaminant classified by IARC as a Group 2B carcinogen, was investigated using an integrated network toxicology and machine learning framework to explore potential molecular mechanisms underlying MC-LR-related hepatocarcinogenesis. By integrating GEO transcriptomic datasets, differential expression analysis, WGCNA, and predicted MC-LR targets, we identified 24 candidate genes potentially associated with MC-LR-related HCC. Functional enrichment analyses implicated these genes mainly in complement and coagulation cascades and metabolic processes. Machine learning consensus analysis prioritized five core genes-AKR1C3, FABP5, CA2, ADH1B, and EPHX2-each showing an AUC greater than 0.79 and suggesting moderate discriminatory potential. Single-gene GSEA linked these genes mainly to ribosome-related pathways, while single-cell transcriptomic analysis revealed cell-type-specific expression heterogeneity within the HCC microenvironment. Molecular docking provided exploratory structural evidence for possible in silico compatibility between MC-LR and the encoded proteins. However, further experimental validation is required to confirm this hypothesis. Overall, these findings establish a multidimensional framework for investigating MC-LR-associated hepatotoxicity and nominate candidate molecular nodes for future biomarker assessment, functional validation, and environment-related HCC risk evaluation. - Source: PubMed
Publication date: 2026/09/29
Xu ZhipengLuo JiLiang JiamingDeng JianwenHe MinjuCao TongfenChen Guangzhao - The prevalence of restless legs syndrome (RLS) among Japanese pregnant women surveyed from 2020 to 2021 was 17.2%, which is higher than that in the general adult population. The onset of this condition involves various factors against a background of genetic predisposition. The presence of the ALDH2*2 allele has been linked to Parkinson's disease, but its association with RLS remains unexamined. This study aimed to clarify the relationship between ALDH2 polymorphism as well as ADH1B polymorphism-already reported to be associated with RLS-and RLS in pregnant women. - Source: PubMed
Publication date: 2026/09/08
Kawahara NatsumiInoue SahoKohtoku YorikoShuo TakuyaTokiya MikikoMatsumoto AkikoEto HiromiKondo Hideaki - Aortic aneurysm (AA) is a life-threatening cardiovascular condition with a strong genetic component, however, its molecular mechanisms remain poorly understood. Although genome-wide association studies (GWAS) have identified numerous risk loci, most prior studies have investigated genetic and metabolic factors separately, leaving the causal pathways from genetic variants to disease largely unexplored. - Source: PubMed
Publication date: 2026/08/24
Wang HanxiCheng JunjieYao JialiJin WentaoLi Wei - Alcohol consumption remains a leading preventable cause of morbidity and mortality; however, abstinence counseling is not routinely implemented in general internal medicine. This review proposes a Japan-oriented framework for translating the diagnosis of alcohol-related diseases into behavioral change interventions. Central to this framework is the concept of the "teachable moment," in which a new diagnosis increases patient motivation and creates opportunities for timely clinical intervention. We reviewed common alcohol-related conditions, including liver disease, alcohol-related cancers, acute pancreatitis, atrial fibrillation, hypertension, hypertriglyceridemia, gout, sleep disorders, and pneumonia, and summarized the evidence that abstinence or reduced alcohol consumption can improve outcomes. We also present an integrated approach that combines brief intervention, liver function-guided pharmacotherapy, nutritional rehabilitation, and specialist collaboration. ALDH2 and ADH1B polymorphisms, common in East Asians, may aid in risk stratification and treatment selection. - Source: PubMed
Publication date: 2026/09/01
Tadokoro TomokoMorishita AsahiroImado RyosukeYano RieNakahara MaiOura KyokoFujita KojiMimura ShimaTani JojiKobara Hideki - Genetic clusters related to Type 2 diabetes (T2D) have differential impact on cardiovascular diseases (CVDs), although the underlying mechanisms, such as proteomic perturbation, remain unexplored. We conducted a network Mendelian randomisation (MR) study to identify proteomic mediators linking T2D genetic clusters and CVDs. - Source: PubMed
Publication date: 2026/08/24
Liao ShuangSung Gabriel Chun YinLiang YiwenLi ChenxiAu Yeung Shiu Lun