CHST2 Blocking Peptide, Blocking Peptides
- Known as:
- CHST2 Blocking Peptide, Blocking Peptides
- Catalog number:
- 33R-6649
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Fitzgerald
- Gene target:
- CHST2 Blocking Peptide Peptides
Related genes to: CHST2 Blocking Peptide, Blocking Peptides
- Gene:
- CHST2 NIH gene
- Name:
- carbohydrate sulfotransferase 2
- Previous symbol:
- -
- Synonyms:
- C6ST
- Chromosome:
- 3q24
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-09
- Date modifiied:
- 2018-05-14
Related products to: CHST2 Blocking Peptide, Blocking Peptides
Related articles to: CHST2 Blocking Peptide, Blocking Peptides
- Keratan sulfate (KS) is a glycosaminoglycan consisting of repeating -acetyllactosamine disaccharides, in which both galactose and -acetylglucosamine are often 6--sulfated. It has been reported that KS recognized by the monoclonal antibodies 5D4 and 373E1 is preferentially expressed in papillary thyroid carcinoma (PTC) and only minimally in other thyroid tumors/lesions or normal thyroid tissue. However, the precise epitopes recognized by these antibodies remain incompletely characterized, and the expression and extent of low-sulfated KS in PTC have not been systematically evaluated. To better understand the nature of KS expressed in PTC, we generated a novel anti-KS monoclonal antibody, 299-1C1, and performed immunohistochemical analyses using 299-1C1 together with two existing anti-KS monoclonal antibodies, 5D4 and R-10G, in combination with keratanase II and endo-β-galactosidase. The results showed that both highly sulfated and low-sulfated KS are preferentially expressed in PTC, including lymph node metastases, accompanied by upregulation of genes encoding key KS biosynthetic enzymes (, , , and ) in integrated TCGA/GTEx transcriptomic datasets. Expression of , , and , but not , was further increased in -mutant PTCs. These findings indicate that anti-KS monoclonal antibodies are useful for the pathological diagnosis of PTC, particularly for distinguishing lymph node metastases from intranodal thyroid inclusions. - Source: PubMed
Publication date: 2026/08/28
Kato EiichiAkama Tomoya OYonemoto NatsumiMuramoto AkifumiFujieda ShigeharuKobayashi Motohiro - Long-term survival of lung transplant recipients remains limited by chronic lung allograft dysfunction (CLAD). CLAD is only diagnosed following a persistent and substantial decline in lung function, after which irreversible damage to the lungs has occurred, limiting opportunities to effectively intervene at an early stage. There is a critical need for earlier detection prior to its clinical manifestation. The immunological drivers of CLAD remain unclear, limiting the development of predictive biomarkers and new therapies. - Source: PubMed
Publication date: 2026/06/23
Iacono GiuliaBegka ChristinaCardwell BaileyDaunt CarmelChatzis RoxannePattaroni CelineButler AlanaMacowan MatthewLevvey BronwynSnell Gregory IWestall Glen PMarsland Benjamin J - Sulfate is a vital nutrient for healthy brain development. More than 90 sulfate-related genes are highly conserved across mammalian species, with 16 of these genes being clinically reportable for adverse brain conditions. To determine the potential involvement of additional sulfate-related genes in human neuropathology, this study curated the spatial and temporal expression patterns of all known sulfate biology genes in the human fetal brain from 8 to 37 post conception weeks (pcw) using data from the BrainSpan database and performed network analysis to cluster sulfate-related genes with genes involved in neurodevelopmental processes. A total of 64 sulfate-related genes were abundantly or moderately expressed in 11 brain regions throughout gestation. Steady state expression was observed for some of these genes from 8 to 37 pcw, including genes that encode sulfotransferases (, ), sulfatases (, , , ), sulfatase modifying enzyme (), key enzymes in amino acid metabolism (, ), sulfate transporter (), as well as genes involved in neurodevelopmental processes (, , , , , ). Between 21-24 weeks, there were numerous clusters of sulfate biology genes with neurodevelopmental genes involved in neuronal migration ( and synaptogenesis (, , , ). At 8-13 and 17-21 pcw, fifteen sulfate genes (, , , , , , , , , , , , , , ) were expressed in the hippocampus and clustered with genes involved in neurogenesis, differentiation and synaptogenesis (, , ). Overall, this study identified 48 sulfate-related genes with moderate/abundant expression in the fetal brain that are coexpressed with genes for neurodevelopmental processes but are not considered in clinical settings. These findings provide information for future studies into the physiological roles of sulfate-related genes that are expressed in the fetal brain. - Source: PubMed
Publication date: 2026/05/08
Vijayakumar PrasidheeSummers Kim MDawson Paul A - Esophageal cancer (ESCA) ranks among the most lethal malignancies worldwide, with late-stage diagnosis, poor prognosis, and limited treatment options contributing to its high mortality. MicroRNAs (miRNAs), short non-coding RNAs with gene-silencing functions, have emerged as crucial regulators in cancer biology and hold promise as diagnostic and therapeutic tools. This study investigates miRNA-mRNA interactions in ESCA using a comprehensive in silico approach to uncover potential regulatory nodes that may underlie tumor progression. Fourteen overexpressed genes in both esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) were selected. TargetScanHuman and miRDB were used to detect miRNAs with high-confidence 8mer seed matches (score ≥90). The majority of genes exhibited multi-miRNA targeting with clustered or overlapping seed regions, indicative of cooperative or redundant repression mechanisms. Several miRNAs demonstrated highly stable interactions, with favorable MFE and ΔG values, reinforcing their silencing potential. GC/GC3 enrichment further supported duplex stability. GO analysis revealed that the target genes are predominantly involved in transcriptional regulation, apoptosis inhibition, immune response modulation, and cell signaling-pathways central to cancer pathogenesis. TCGA-based validation showed that only a subset of predicted interactions is functionally relevant, with hsa-miR-30d-5p exhibiting a significant inverse correlation with CHST2. These findings highlight the importance of integrating predictive and expression data to identify biologically meaningful miRNA-mRNA interactions in esophageal cancer. - Source: PubMed
Publication date: 2026/04/26
Choudhury Sabnam NasrinMazumder Tarikul HudaSaikia SahidulUddin Arif - Sulfated -glycans are widely distributed and play key roles in a wide range of physiological and disease processes, yet their synthesis remains challenging due to difficulties in regioselective sulfation. Here, we systematically characterized two human GlcNAc-6--sulfotransferases, CHST2 and CHST6, revealing their strong preference towards -glycans (including -GalNAc and -mannosyl glycans) over -glycans and poly-LacNAc chains. Both enzymes favored β1-6 branched GlcNAc residues, with CHST6 showing higher activity and broader substrate tolerance than CHST2. Guided by these insights, we established a modular enzymatic assembly platform for efficient synthesis of 32 well-defined sulfated -GalNAc, -mannosyl glycans, and -glycopeptides. This streamlined strategy enables versatile access to sulfated -glycans and provides a general route for constructing other classes of sulfated glycans. - Source: PubMed
Publication date: 2026/04/13
Fan ShuquanHan JinghuaShen TangliangShabahang MohammadHosseinDu ZhenmingPan JunBai GuitaoBao ShuminIttuveetil AvinashLi Lei