PIGK Blocking Peptide, Blocking Peptides
- Known as:
- PIGK Blocking Peptide, Blocking Peptides
- Catalog number:
- 33R-5803
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Fitzgerald
- Gene target:
- PIGK Blocking Peptide Peptides
Related genes to: PIGK Blocking Peptide, Blocking Peptides
- Gene:
- PIGK NIH gene
- Name:
- phosphatidylinositol glycan anchor biosynthesis class K
- Previous symbol:
- -
- Synonyms:
- hGPI8, GPI8
- Chromosome:
- 1p31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-05-17
- Date modifiied:
- 2015-11-06
Related products to: PIGK Blocking Peptide, Blocking Peptides
Related articles to: PIGK Blocking Peptide, Blocking Peptides
- This study aimed to reveal the mechanism and prognostic significance of migrasome-related genes (MGs) in primary liver cancer (PLC) treated with Sorafenib (Sor) treatment. - Source: PubMed
Publication date: 2026/05/16
Wang LeiWan ZhaoxiaGao LinluDing FeiGao KunYin Xiaoling - An individual's host genetics influence its susceptibility to both COVID-19 and coronary artery disease (CAD). We analyzed large-scale GWAS datasets encompassing 7.7 million SNPs to identify shared genetic architecture between the two diseases. We identified 24 pleiotropic risk loci for both COVID-19 and CAD, with three loci (1p31.1, 8p21.3, and 18q11.2) showing strong evidence for a single shared causal variant. Loci in the 8p21.3 and 18q11.2 regions showed a bidirectional causal association: COVID-19 to CAD or vice versa, while the 1p31.1 locus only showed a CAD to COVID-19 unilateral casual association in a Mendelian randomization analysis (GSMR). A fine mapping analysis of the three loci identified three lead pleiotropic variants (rs7515509, rs8192330, and rs4800403). The variant rs7515509 was spatially associated with , and ; rs8192330 with , and several other genes; and rs4800403 with and . Transcriptomic profiling of peripheral blood mononuclear cells (PBMCs) from COVID-19 patients validated proxitropic variants (rs8192330 and rs4800403) with distinct expression signatures and prioritized and as the likely causal genes. Overexpression of has been linked to the heme metabolism hallmark, disrupted iron distribution in COVID-19 patients with comorbid CAD, and subsequent stress erythropoiesis, oxidative stress, immunological dysfunction, and altered wound healing, while a lower expression of has been observed in the cytoplasmic translation and regulation of mRNA metabolism. In conclusion, we identified shared genetic components for COVID-19 and CAD and prioritized and as the likely causal genes for the observed shared genetic risk. COVID-19 may act as an acute stressor that unmask or accelerates underlying CAD. - Source: PubMed
Publication date: 2026/05/05
Ali Muhammad SarfrazHaider WaseemAziz SanaMohammad AnwaruddinManichaikul AniShi Weibin - Diabetic foot ulcer (DFU) is a complication of diabetes, characterized by impaired healing and chronic wounds that compromise quality of life. Migrasomes are newly discovered organelles involved in processes such as morphogenesis and angiogenesis, but their role in tissue repair and diabetic wound healing remains unknown. This study investigated the involvement of migrasomes in the pathogenesis and repair of DFU. - Source: PubMed
Publication date: 2026/03/30
Wang JieZhu MiaoJiang ZongzheLiao GuohuiXu CaiminJiang NanChen Qi - PIGK-related glycosylphosphatidylinositol (GPI) biosynthesis disorder is an extremely rare neurodevelopmental condition, with only 12 cases described to date. It is caused by biallelic mutations in the gene, which encodes a catalytic subunit of the GPI transamidase complex. This enzyme facilitates the attachment of GPI anchors to proteins crucial for cellular signaling and development. Eight of the 12 described cases were reported to have seizures, but the electroclinical characteristics are not well defined. - Source: PubMed
Publication date: 2026/01/30
Lateef ShanLewanda Amy FeldmanWeston JuliaBade SarahLessard Jacklyn - Glycosylphosphatidylinositol transamidase (GPI-T) catalyzes the attachment of glycosylphosphatidylinositol (GPI) anchors to membrane proteins implicated in oncogenic signaling. However, the specific contribution of individual GPI-T subunits to head and neck cancer (HNC) remains unclear. - Source: PubMed
Publication date: 2026/01/01
Yang Yi-FangLiao Jia-BinYu Pei-LunChou Chih-YuLin Yu-Hsuan