PYCR1 Blocking Peptide, Blocking Peptides
- Known as:
- PYCR1 Blocking Peptide, Blocking Peptides
- Catalog number:
- 33R-4559
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Fitzgerald
- Gene target:
- PYCR1 Blocking Peptide Peptides
Related genes to: PYCR1 Blocking Peptide, Blocking Peptides
- Gene:
- PYCR1 NIH gene
- Name:
- pyrroline-5-carboxylate reductase 1
- Previous symbol:
- -
- Synonyms:
- P5C
- Chromosome:
- 17q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-24
- Date modifiied:
- 2015-09-07
Related products to: PYCR1 Blocking Peptide, Blocking Peptides
Related articles to: PYCR1 Blocking Peptide, Blocking Peptides
- Hepatocellular carcinoma (HCC) is the most common primary liver cancer in adults, with increasing incidence. It is helpful to establish a prognostic risk prediction model related to macrophage polarization and mitochondrial dysfunction associated with HCC. - Source: PubMed
Publication date: 2026/07/17
Cheng Bin-BinTu Wei-PingTu Xiao-YuLi Bai - Proline metabolism has been associated with schizophrenia pathophysiology; however, the underlying molecular mechanisms remain elusive. This study aimed to investigate the changes in the entire proline metabolic pathway in postmortem brains of patients with schizophrenia. Herein, enzyme-linked immunosorbent assay was performed to determine the protein levels of proline metabolism-associated key enzymes (prolidase [PEPD], proline dehydrogenase [PRODH], pyrroline-5-carboxylate synthetase [ALDH18A1], ornithine aminotransferase [OAT], and pyrroline-5-carboxylate reductase 1 [PYCR1]). Additionally, amino acids metabolized through the proline pathway, including proline, ornithine, and glutamic acid, were quantitatively analyzed through liquid chromatography-tandem mass spectrometry. The alterations in the expression of proline metabolism-associated enzymes and associated amino acid levels were analyzed in the postmortem brains of individuals with schizophrenia, and their associations with premortem clinical symptom scores were examined. Notably, in patients with schizophrenia, PRODH and PYCR1 expression significantly decreased in the superior temporal gyrus and prefrontal cortex, respectively, whereas amino acid levels showed no significant differences. Overall, the findings of this study show that dysregulation in proline metabolism may contribute to mitochondrial dysfunction owing to its close association with energy production and redox regulation. These results suggest the underlying pathophysiology of schizophrenia and provide insights for developing novel therapeutic strategies for managing schizophrenia. - Source: PubMed
Publication date: 2026/06/26
Nagaoka AtsukoHino MizukiShishido RisaHatano MasatakaHosogai YutoKano AkimuHamasaki HideomiKakita AkiyoshiTomita HiroakiKunii Yasuto - Microgravity during spaceflight is increasingly associated with cutaneous impairment, yet the structural basis and underlying metabolic mechanisms remain poorly defined. Collagen, the main component of the dermal extracellular matrix (ECM), relies on de novo proline synthesis in fibroblasts. Herein, we examined whether simulated microgravity (SMG) affects collagen synthesis by altering the proline biosynthetic pathway. - Source: PubMed
Publication date: 2026/06/25
Wang WenbinPeng XiufenLuo QingSong Guanbin - Pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme in proline biosynthesis, has been implicated in various cancers. However, its role in clear cell renal cell carcinoma (ccRCC) remains elusive. - Source: PubMed
Publication date: 2026/06/23
Zhou JizheZhou YutingLi HaifengJiang MinlinGuo YueyueXie DelongYi SanguiLiu Zongling - Osteosarcoma treatment outcomes are compromised by increased drug resistance, distant metastasis, and tumor recurrence. While Pyrrolidine-5-carboxylic acid reductase 1(PYCR1) knockdown has been shown to inhibit tumor proliferation and migration in certain cancers. Its effects in osteosarcoma and regulatory mechanisms within osteosarcoma cells have not been explored. This study investigated the role of PYCR1 in osteosarcoma proliferation and its potential molecular mechanisms. The expression of PYCR1 was assessed in osteosarcoma tissues by immunohistochemistry and its correlation with clinical outcomes was determined. Subsequently, lentivirus-mediated knockdown and over expression of PYCR1 was achieved in osteosarcoma cells to evaluate its impact on proliferation, colony formation, and migration ability. The PI3K/Akt signaling pathway and its downstream effector COL1A1 were investigated using a combination of biomarker analysis, transcriptome sequencing, and co-immunoprecipitation assays. Subsequent silencing of COL1A1 induced phenotypic changes and confirmed tumorigenicity in vivo. The ferroptosis agonist Erastin and its specific antagonist Ferrostatin-1 (Fer-1) were combined with PYCR1 knockdown to explore their correlation with ferroptosis. By applying the pathway inhibitor LY294002, it was confirmed that the PI3K/Akt pathway is crucial for osteosarcoma proliferation. This study confirms that PYCR1 drives osteosarcoma cell proliferation and migration through three key mechanisms: regulating downstream genes, inhibiting ferroptosis, and activating the PI3K/Akt signaling pathway. - Source: PubMed
Publication date: 2026/06/19
Hu JianhuaHuang YiyuanChen HaomingXie ZehaoYan HanLi HaomiaoLi Runguang