GABRA5 Blocking Peptide, Blocking Peptides
- Known as:
- GABRA5 Blocking Peptide, Blocking Peptides
- Catalog number:
- 33R-3620
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Fitzgerald
- Gene target:
- GABRA5 Blocking Peptide Peptides
Related genes to: GABRA5 Blocking Peptide, Blocking Peptides
- Gene:
- GABRA5 NIH gene
- Name:
- gamma-aminobutyric acid type A receptor alpha5 subunit
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 15q12
- Locus Type:
- gene with protein product
- Date approved:
- 1992-08-07
- Date modifiied:
- 2016-02-04
Related products to: GABRA5 Blocking Peptide, Blocking Peptides
Related articles to: GABRA5 Blocking Peptide, Blocking Peptides
- This study aimed to identify genetic markers for body weight in adult male Dongfeng sika deer (Cervus nippon) using a genome-wide association study (GWAS). A cohort of 266 healthy, five-year-old stags was phenotyped and genotyped via whole-genome resequencing. Population structure was assessed, and a mixed linear model (MLM) was employed for association testing, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of candidate genes. The GWAS identified twelve genome-wide significant SNP loci, which were annotated to seven candidate genes: ERC2, LOC122708028, FHIT, CASP14, UBE3A, NRXN3, and GABRA5. Functional enrichment analyses revealed these genes are significantly involved in the γ-aminobutyric acid (GABA)ergic synaptic transmission pathway and pathways related to DNA damage repair and cell cycle regulation. This study provides insights into the genetic mechanisms underlying body weight traits in adult male Dongfeng sika deer and offers a reference for subsequent functional exploration of candidate genes. - Source: PubMed
Publication date: 2026/06/11
Zhang XinyuanZhang YanZhao LiepingZhao YaoQian Wen-XiGai GuanghuiSong JunDu PeizeHan HuanshengZhang Zhen - To investigate the association between polymorphisms in the , , and genes and growth traits in Dongfeng sika deer and to identify potential molecular markers for breeding, this study was conducted based on prior genome-wide association analysis. Based on the previous GWAS analysis of 266 Dongfeng sika deer, the SNP loci of , , and genes were detected in 36 male deer samples. The genetic parameters were calculated, and an association analysis with growth traits was carried out. Phenotypic analysis indicated that body weight and chest circumference had higher coefficients of variation than other growth traits, and body weight showed a strong positive correlation with body-slant length (r = 0.743, < 0.01) and a moderate correlation with chest circumference (r = 0.709). A total of six SNP loci were identified, including three within (Chr13-8442730, Chr13-9033380, and Chr13-9045819), one within (Chr14-5681678), and two within (Chr20-66603370 and Chr20-66618510). The dominant genotypes at these loci include CG (CC), AA, CG, CC (CG), AA, and GG (GC). Linkage disequilibrium analysis revealed a relatively strong association between Chr13-8442730 and Chr13-903380 on chromosome 13. Combined genotype analysis showed that diplotype CCCGGC was associated with higher body weight and larger chest circumference than other genotype combinations. Gene expression analysis showed that the relative expression levels of , , and were lower in the low-growth group than in the high-growth group, and expression variation was also observed within groups. Overall, gene expression levels appeared to be positively associated with growth traits, with higher expression associated with improved growth performance. These findings suggest that and may serve as candidate genes for further investigation and that the identified SNP loci may contribute to the development of molecular markers for the selection of growth traits in Dongfeng sika deer. The results provide a preliminary basis for molecular breeding and genetic improvement strategies in Dongfeng sika deer bucks and serve as an important reference for genetic improvement of growth traits in Cervidae. - Source: PubMed
Publication date: 2026/06/03
Zhang YanZhang XinyuanHan HuanshengWang Xue - Dynamic modulation of α5-GABAAR expression and synaptic distribution plays a pivotal role in neuronal homeostatic plasticity, critically influencing memory processes. This study aims to investigate the spatiotemporal dynamics of α5-GABAAR in hippocampal subregions (CA1, CA3, and DG) and their behavioral correlation in mice following sevoflurane exposure across eight timepoints. - Source: PubMed
Wang SixuanChen LuWang ShengranZhang ChenZhang MengxueWang ZhunDong JinpengLiu QiangweiDong ZhonglanWang XiaokunDong YingLuo YuanWang YonganYin Yiqing - Late-life depression (LLD) is a debilitating condition, characterized by mood disturbance and cognitive decline. Gamma-aminobutyric acidergic (GABAergic) deficits are a hallmark of both aging and depression; however, few studies have examined the GABAergic system in LLD. We hypothesized that there would be significant decrease in peripheral GABA levels and γ-aminobutyric acid type A (GABA-A) receptor subunit expression in individuals with LLD compared to healthy controls (HC). In this study, we measured plasma GABA levels and the mRNA expression of four GABA-A receptor subunits (GABRA1, GABRA4, GABRA5, and GABRR2) in peripheral blood mononuclear cells (PBMCs) from 87 older adults (LLD, n = 46; HC, n = 41). Plasma GABA levels were quantified using enzyme-linked immunosorbent assay (ELISA), and receptor subunit expression was assessed by quantitative-real time (RT-qPCR). There were no significant differences between LLD and HC in plasma GABA levels or GABA-A receptor subunit expression. In LLD, within-group analyses showed GABRA5, GABRR2, GABRA4, GABRA1 expression were negatively correlated with cognitive performance on the Montreal Cognitive Assessment MoCA scores (ρ = -0.464, p = 0.045, ρ = -0.515, p = 0.041; ρ = -0.414, p = 0.078, and ρ = -0.477, p = 0.062 respectively). This is the first study that investigated GABA-A receptor subunit expression in the periphery of individuals with LLD. Our findings suggest that altered peripheral GABA-A receptor subunit expression, even in the absence of between-group differences, is associated with reduced cognitive function in LLD. - Source: PubMed
Publication date: 2026/05/03
Rezaei SaraSibille EtienneVoineskos DaphneRajji Tarek KNikolova Yuliya SDiniz Breno SVieira Erica L - Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive and memory decline. An imbalance in the excitatory/inhibitory (E/I) neurotransmitter systems is hypothesized to play a significant role in the pathological mechanisms underlying this cognitive failure. As therapies targeting the excitatory side of this E/I balance provide only mild symptomatic relief, modulating inhibitory GABAergic neurotransmission has emerged as a potential therapeutic strategy for AD. α5 GABA type A receptors (α5-GABAARs) are of particular interest given their high expression in the hippocampus and involvement in learning and memory processes. Positive and negative allosteric modulators of α5-GABAARs have been developed with the converging aim of cognitive enhancement. This perspective explores the current literature on positive and negative allosteric modulators of α5-GABAARs in AD and proposes a model where two drug classes with opposing mechanisms can both offer therapeutic potential. Current evidence suggests that α5-GABAAR modulation may play divergent, circuit-dependent roles, such that negative allosteric modulators could enhance cognition in conditions of excessive inhibition, while positive allosteric modulators may be beneficial in hyperexcitable circuits. Ultimately, the successful clinical translation of α5-GABAAR positive and negative allosteric modulators will require careful phenotyping of neuronal activity and E/I balance to align pharmacological strategies with circuit state. - Source: PubMed
Publication date: 2026/04/17
O'Connell AoifeKwakowsky Andrea