ELISA Mouse , TNF-alpha
- Known as:
- Enzyme-linked immunosorbent assay test Mouse , TNF-a
- Catalog number:
- RBMS607/2R
- Product Quantity:
- 96 wells (1 kit)
- Category:
- -
- Supplier:
- Biovend
- Gene target:
- ELISA Mouse TNF-alpha
Related products to: ELISA Mouse , TNF-alpha
Related articles to: ELISA Mouse , TNF-alpha
- Perianal fistulising Crohn's disease (pfCD) is a debilitating phenotype and remains a therapeutic challenge. Current guidelines recommend anti-tumour necrosis factor agents as first-line therapy for pfCD; however, there is still no consensus on the optimal pharmacological strategy once anti-TNF therapy fails. Upadacitinib, an oral selective Janus kinase 1 inhibitor, has demonstrated efficacy in moderate-to-severe Crohn's disease. Nevertheless, real-world data specifically addressing its effectiveness and safety in the refractory pfCD population remain scarce. This study aims to evaluate the real-world effectiveness and safety of upadacitinib in patients with active pfCD who have failed anti-TNF therapy. - Source: PubMed
Publication date: 2026/09/23
Lu ChongXu DongboQian KeyuDou LingyunDing YaqingFa JingjingLin ChaoyiLiu XinHuang ChunlanZeng YueYao YiboWang QunyingWu YanglongWang RunqiCao DongxingZhang YeCao ZhijunCui Zhe - Chronic low-grade inflammation has been widely acknowledged as an important pathophysiological mechanism underlying depression. Probiotics may alleviate depressive symptoms by modifying the microbiota-gut-brain axis and regulating inflammatory responses. The purpose of this systematic review and meta-analysis was to assess the effect of probiotic supplementation on circulating inflammatory biomarkers in depressed individuals. - Source: PubMed
Publication date: 2026/09/23
Lachinani FaezeMilajerdi Alireza - Opuntia ficus-indica (OFI), a plant native to the Americas, has been used since pre-Hispanic times in Mexican traditional medicine as both a food source and an herbal remedy for various ailments. Its reported antioxidant and immunomodulatory properties support its traditional use and suggest potential therapeutic applications in inflammatory disorders. - Source: PubMed
Publication date: 2026/09/23
Calvillo-Rodríguez Kenny MisaelSauceda López Joshua JaelGonzález-Flores María NormaLorenzo-Anota Helen YarimetVazquez-Rodriguez Jesus AlbertoLozano-Garcia OmarRodríguez-Padilla María CristinaAntunes-Ricardo MarilenaMartínez-Torres Ana Carolina - Lipid rafts, cholesterol- and glycosphingolipid-rich membrane platforms with stimuli-transducing molecules, facilitate cancer cell migration via aggregation. TNF receptor associated factor 6 (TRAF6), a known oncogene in lung cancer, interacts with receptor activator of nuclear factor-kB (RANK) (localized on lipid rafts) and Cellular (c)-Src (a lipid raft component), leading us to hypothesize that blocking lipid raft-localized RANK/c-Src may attenuate TRAF6-driven tumor progression. - Source: PubMed
Publication date: 2026/09/23
Zhou DanfeiYing JunLiu HaijianHu ShanshanLi JiangdongRen Jiaojiao - Prenatal ethanol exposure (PEE) alters neurobehavioral function, yet the factors associated with these effects, particularly in interaction with stress, remain poorly understood. We examined whether combined exposure to PEE and adolescent restraint stress altered compulsive-like behavior and, in the sex showing the clearest combined effects, assessed gut microbiota composition and neuroimmune-related gene expression. Male and female Wistar rats exposed to ethanol on gestational days 17-20 were subjected to restraint stress (RES) or control conditions during adolescence. Behavioral assessments included the open field, light-dark box, marble burying, and perseverance tasks. Gut microbiota composition was analyzed using 16S rRNA sequencing, and central gene expression of inflammatory and neuromodulatory markers was measured. Behavioral effects were sex-dependent. In males, the combined PEE+RES condition produced a compulsive-perseverative phenotype, reflected by increased marble burying and reduced return latency to a specific object. In females, increased marble burying was observed after PEE alone. Microbiota analyses, conducted in males only due to them exhibiting the greatest joint effects of the PEE+RES exposure, revealed no significant differences in overall beta diversity, but identified several taxon-specific reductions. These reductions, which were most pronounced under combined PEE+RES exposure, involved members of the Lactobacillaceae, Muribaculaceae, Christensenellaceae, and Lachnospiraceae families, as well as the genera Butyricicoccus and Intestinimonas. PEE and RES were associated with region- and marker-specific alterations in Tnf and Oxtr gene expression. The findings suggest the involvement of the microbiota-gut-brain axis in the effects of PEE, with RES potentially exacerbating this vulnerability. - Source: PubMed
Publication date: 2026/09/23
Fabio María CarolinaSanchez MónicaMarengo LeonardoRavasi CamilaDi Bartolomeo MartinaWille-Bille AranzaPucci MariangelaSabatucci AnnalauraDi Domenico MarcoSecondini BarbaraD'Addario ClaudioPautassi Ricardo Marcos