ELISA Human , TIE-2
- Known as:
- Enzyme-linked immunosorbent assay test Human , TIE-2
- Catalog number:
- RBMS2042R
- Product Quantity:
- 96 wells (1 kit)
- Category:
- -
- Supplier:
- Biovend
- Gene target:
- ELISA Human TIE-2
Related genes to: ELISA Human , TIE-2
- Gene:
- TEK NIH gene
- Name:
- TEK receptor tyrosine kinase
- Previous symbol:
- VMCM
- Synonyms:
- TIE2, TIE-2, VMCM1, CD202b
- Chromosome:
- 9p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-05-24
- Date modifiied:
- 2018-08-07
Related products to: ELISA Human , TIE-2
Related articles to: ELISA Human , TIE-2
- Problematic usage of the internet (PUI) is a steadily growing public health issue that requires better understanding of the underlying psychological mechanisms to optimize prevention and treatment. This study aimed at investigating affective and cognitive processes that may explain symptoms of PUI cross-sectionally and longitudinally. - Source: PubMed
Publication date: 2026/04/10
Brand MatthiasBrandtner AnnikaAntons StephanieMüller AstridStark RudolfFineberg Naomi APotenza Marc NSteins-Loeber SabineWegmann ElisaMüller Silke M - Single cell/nuclei technologies have revolutionized our understanding of the remodeling of complex multi-cellular tissue that accompanies injury, regeneration, and disease. Duchenne muscular dystrophy (DMD) is a fatal genetic disease of childhood characterized by progressive skeletal muscle weakness resulting from mutation of DMD and loss of functional dystrophin. Here we report, at single nuclei/cell resolution, on intramuscular cell and gene expression dynamics within a broad cohort of needle muscle biopsies obtained from DMD individuals with varying degrees of severity, including a subset with low levels of dystrophin. We report a strong negative correlation between expression of dystrophin and disease severity and report substantial differences in cellularity and cell type-specific gene expression in DMD severity groups versus healthy muscle. Expression signatures indicate that DMD myofibers become immunologically alert, upregulating innate and adaptive immune sensors, including TLR4, IL15, TNF family receptors and MHC and costimulators. In this cohort, dystrophic muscle was remodeled with 50% fewer myofibers with expansion and diversification of fibroblasts and myeloid cells. We identify a DMD-specific TNFα-responsive Thy-1+/C3+ fibroblast subpopulation which we propose are inflammatory tissue priming fibroblasts and three DMD-specific myeloid populations which express signatures of innate immune memory. There is an 8-fold increase in CD8+GZMK+/GZMB+ T cells (Tek), with characteristics of both adaptive and innate immune activity. We propose that these non-myofiber muscle resident cells interact and epigenetically instill long-term tissue memory to perpetuate and amplify a hyper-inflammatory state in DMD muscle, contributing to impaired regeneration, myofiber death and fibrosis. This compendium of single/cell nuclei serves as a valuable reference and has immediate impact for biomarker discovery, clinical trial design, identification of barriers to dystrophin replacement therapies and novel druggable cell mechanisms operating in DMD. - Source: PubMed
Publication date: 2026/04/08
Miceli M CarrieChesmore KevinScripture-Adams DeirdreBarthelemy FlorianLittle IsaiahWang RichardNieves-Rodriguez ShirleyCorona RosarioSteady NicoleYip ArtemisDouine-Barthelemy EmilieNelson StanleyRengarajan SophieNasif DanielaSen Annabel - Achieving physiologic glucocorticoid replacement in adrenal insufficiency (AI) remains challenging, as both under- and over-replacement contribute to morbidity. Hair cortisol concentration (HCC) reflects cumulative cortisol exposure and may provide clinically relevant information beyond single-time-point assessments. - Source: PubMed
Publication date: 2026/04/01
Korkmaz Yilmaz MerveTek SemihKaratas Kiliccioglu GizemUnver Ozkahraman AyselNiyazoglu MutluHatipoglu Esra - This study aims to evaluate the effect of the type of intervention (bedside vs. operating room incision and drainage) on clinical outcomes in the treatment of perianal abscess and to identify predictive factors that may be effective in determining the type of intervention. - Source: PubMed
Gungor FeyyazKılavuz HüseyinYıldız NejdetDemir MuratBekraki AliSari SerkanKurtulus Idris - Upper gastrointestinal bleeding (UGIB) is a significant cause of morbidity and mortality. While endoscopy is the primary treatment modality, transcatheter arterial embolization (TAE) can be an effective alternative when endoscopic treatment fails. This study aims to evaluate the safety and efficacy of empiric TAE for acute UGIB. - Source: PubMed
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