ELISA Human , Bcl-2
- Known as:
- Enzyme-linked immunosorbent assay test Human , Bcl-2
- Catalog number:
- RBMS244/3R
- Product Quantity:
- 96 wells (1 kit)
- Category:
- -
- Supplier:
- Biovend
- Gene target:
- ELISA Human Bcl-2
Related genes to: ELISA Human , Bcl-2
- Gene:
- BCL2 NIH gene
- Name:
- BCL2 apoptosis regulator
- Previous symbol:
- -
- Synonyms:
- Bcl-2, PPP1R50
- Chromosome:
- 18q21.33
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: ELISA Human , Bcl-2
Related articles to: ELISA Human , Bcl-2
- Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with limited therapeutic options and poor survival. Resistance to standard temozolomide (TMZ) therapy remains a major challenge, necessitating novel agents. Tropolone derivatives, particularly the synthetic trichlorotropolone JO-122(2), have shown broad preclinical antitumor activity. This study aimed to determine whether JO-122(2), alone or combined with TMZ, can suppress GBM growth in vivo and to define the accompanying changes in the p53/MDM2/Bcl-2 apoptotic axis. - Source: PubMed
Publication date: 2026/06/24
Kit Oleg IMaksimov Aleksey YuGolovinov Igor VKuznetsova Natalia SKaplieva Irina VKhodakova Daria VSagakyants Alexander BGalina Anastasia VShulga Anna AGurova Sofya VBondarenko Elena SRostorguev Eduard ESayapin Yurii AGusakov Eugeny A - Understanding the molecular effects associated with glyphosate exposure remains challenging due to the fragmentation of available evidence across heterogeneous data sources. This study aimed to integrate heterogeneous molecular evidence related to glyphosate exposure through a reproducible systems biology workflow in order to prioritize human genes, regulatory networks, and biological processes associated with glyphosate. Multiple platforms, including the Comparative Toxicogenomics Database (CTD), GeneShot, and GeneCards, were queried and complemented with artificial intelligence-assisted information retrieval. Genes present in at least two independent sources were selected, and additional candidates were obtained from transcriptomic datasets using GEO2R. Gene identifiers were standardized according to the HUGO Gene Nomenclature Committee (HGNC). Functional enrichment and protein-protein interaction (PPI) network analyses were performed using STRING and Cytoscape, and hub genes were identified using the cytoHubba plugin. In addition, upstream transcription factor analysis was conducted to identify potential regulatory drivers of the gene network. The resulting consensus dataset was subsequently analyzed using protein-protein interaction networks, functional enrichment, and upstream regulatory inference. The integrative workflow prioritized a core set of 50 genes was identified, with key hub genes including , and . Enrichment analyses revealed a consistent overrepresentation of pathways related to cellular stress response, apoptosis, endocrine signaling, and cancer, along with a specific epigenetic signal associated with DNA methylation. Upstream regulatory analysis identified key transcription factors linked to hormonal signaling, cellular stress response, and transcriptional control, further supporting the hierarchical organization of the gene network. Gene-disease and phenotype associations further highlighted links with hepatobiliary disorders, neoplastic processes, and endocrine alterations. Overall, this integrative systems biology framework provides a comprehensive view of the molecular architecture associated with glyphosate exposure, prioritizing candidate genes, regulatory networks, and biological processes for hypothesis generation and future experimental and epidemiological validation. - Source: PubMed
Publication date: 2026/08/20
Consuegra-Mayor ClaudiaArroyo-Salgado BarbaraOlivero-Verbel Jesus - Radiotherapy remains a fundamental modality in cancer treatment; however, its efficacy is frequently compromised by inherent tumor radioresistance and the collateral damage to normal tissues at curative doses. Phloretin, a dihydrochalcone flavonoid, exhibits extensive antitumor effects in both in vitro and in vivo settings; however, its clinical application is limited due to low water solubility and rapid metabolic processing. Silver nanoparticles (AgNPs) have been recognized as agents that enhance radiation-induced oxidative damage. Accordingly, this study synthesized phloretin-conjugated AgNPs (Ph-AgNPs) and evaluated their potential as a safe, tumor-selective radiosensitizer in a murine model of solid Ehrlich carcinoma. - Source: PubMed
Publication date: 2026/08/24
Hisham NouranHussein Mohammed AbdallaAwad W MAlsubayae ReemaSallah MohammedAbdelraze E M - The anti-apoptotic molecule BCL-2 favours the maintenance of the CD4 T-cell reservoir during HIV infection. Whether inhibition of BCL-2 can lead to long-term reduction of the HIV reservoir is unclear. Here we initiated antiretroviral therapy (ART) in 24 simian immunodeficiency virus (SIV)-infected rhesus macaques at 14 days post infection (p.i.), alone or combined with a 10-day treatment of venetoclax or venetoclax and CD8α depletion, with a follow-up to day 294 p.i. We report a rapid and sustained reduction of the intact SIV reservoir in venetoclax-treated rhesus macaques in blood and lymph nodes. CD4 T cells that persisted after venetoclax treatment showed partial reduction in apoptotic sensitivity in ex vivo assays. These exhibited elevated expression of anti-apoptotic BCL-2 and BCL-xL, and showed reduced expression of pro-apoptotic molecules such as PUMA. These findings support the rationale for extended venetoclax dosing and suggest that combining BCL-2 inhibition with agents targeting additional anti-apoptotic molecules could enhance clearance of the viral reservoir in HIV cure strategies. - Source: PubMed
Publication date: 2026/09/03
Wiche Salinas Tomas RaulHarper JustinDeleage ClaireNguyen KevinAuger JamesFlores Hannah RKaushik Sandeep RWilkes Amelia CStammen Rachelle LWood Jennifer SEasley Kirk ANelson SydneyTharp Gregory KBosinger Steven ECottrell Mackenzie LKose EmekImmonen Taina TLifson Jeffrey DLaird Gregory MKeele Brandon FJones R BradBadley Andrew DSilvestri GuidoKulpa Deanna APaiardini Mirko - Apoptosis is regulated by Bcl-2 family of proteins through direct binding interactions at the mitochondrial outer membrane. Bak, a key cellular executioner protein in this family, differs from the other executioner proteins Bax and Bok in that it is constitutively localized at the mitochondrial outer membrane via its C-terminal sequence (CTS). Binding of the BH3-only protein Bim triggers conformational changes in Bak that lead to oligomerization and mitochondrial membrane permeabilization. However, the molecular mechanism by which Bim activates Bak remains incompletely understood. Here we demonstrate both in vitro and in cells, that efficient Bim-mediated activation of Bak requires not only the binding of the BH3-motif of Bim to the canonical BH3-binding groove of Bak, but also sequence specific, direct binding of the Bim-CTS to the Bak-CTS. These findings reveal an unexpected contribution of the Bak-CTS to the molecular control of Bak activation during apoptosis. - Source: PubMed
Publication date: 2026/09/03
Nguyen DangTrebinjac SabinaBeigl Tobias BEssmann FrankMurphy Kathryn MAndrews David W