Mouse Anti Human Cofilin-1 CFL1
- Known as:
- Mouse Anti Human Cofilin-1 CFL1
- Catalog number:
- ant-354
- Product Quantity:
- 5
- Category:
- -
- Supplier:
- Prospecbio
- Gene target:
- Mouse Anti Human Cofilin-1 CFL1
Related genes to: Mouse Anti Human Cofilin-1 CFL1
- Gene:
- CFL1 NIH gene
- Name:
- cofilin 1
- Previous symbol:
- CFL
- Synonyms:
- -
- Chromosome:
- 11q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-16
- Date modifiied:
- 2016-01-19
- Gene:
- VPS72 NIH gene
- Name:
- vacuolar protein sorting 72 homolog
- Previous symbol:
- TCFL1
- Synonyms:
- YL-1, YL1, Swc2
- Chromosome:
- 1q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-12-08
- Date modifiied:
- 2016-10-05
Related products to: Mouse Anti Human Cofilin-1 CFL1
Related articles to: Mouse Anti Human Cofilin-1 CFL1
- The eukaryotic nucleus remodels extensively during mitosis. Upon mitotic entry, the nuclear envelope breaks down and chromosomes condense into rod-shaped bodies, which are captured by the spindle apparatus and segregated during anaphase. Through telophase, chromosomes decondense and the nuclear envelope reassembles, leading to a functional interphase nucleus. While the molecular processes occurring in early mitosis are intensively investigated, our knowledge about molecular mechanisms of nuclear reassembly is rather limited. Using cell free and cellular assays, we identify the histone variant H2A.Z and its chaperone VPS72/YL1 as important factors for reassembly of a functional nucleus after mitosis. Live-cell imaging shows that siRNA-mediated downregulation of VPS72 extends the telophase in HeLa cells. In vitro, depletion of VPS72 or H2A.Z results in malformed and nonfunctional nuclei. VPS72 is part of two chromatin-remodeling complexes, SRCAP and EP400. Dissecting the mechanism of nuclear reformation using cell-free assays, we, however, show that VPS72 functions outside of the SRCAP and EP400 remodeling complexes to deposit H2A.Z, which in turn is crucial for formation of a functional nucleus. - Source: PubMed
Publication date: 2020/07/16
Moreno-Andrés DanielYokoyama HidekiScheufen AnjaHolzer GuillaumeLue HongqiSchellhaus Anna KatharinaWeberruss MarionTakagi MasatoshiAntonin Wolfram