Mouse Anti Human Caveolin-1 CAV1
- Known as:
- Mouse Anti Human Caveolin-1 CAV1
- Catalog number:
- ant-027
- Product Quantity:
- 5
- Category:
- -
- Supplier:
- Prospecbio
- Gene target:
- Mouse Anti Human Caveolin-1 CAV1
Related genes to: Mouse Anti Human Caveolin-1 CAV1
- Gene:
- CAV1 NIH gene
- Name:
- caveolin 1
- Previous symbol:
- CAV
- Synonyms:
- -
- Chromosome:
- 7q31.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-02
- Date modifiied:
- 2016-10-05
Related products to: Mouse Anti Human Caveolin-1 CAV1
Related articles to: Mouse Anti Human Caveolin-1 CAV1
- Type 2 diabetes mellitus (T2D) exacerbates Alzheimer's disease (AD). Dendrobium nobile Lindl. alkaloids exhibited beneficial effects against T2D and/or AD. Dendrobine, a main alkaloid of Dendrobium nobile, against T2D/AD comorbidity was further examined in this study. - Source: PubMed
Publication date: 2026/04/15
Xu FengqingYi YangChi LulanLiu BoZhang WeiWu QinLi Zheng - High pathogenicity avian influenza (HPAI) devastates the poultry industry worldwide due to its rapid spread, severe pathology, and high mortality in chickens. Why some infected birds survive while others die remains poorly understood. Here, we tracked early host transcriptomic responses (8-72 hours post-inoculation [hpi]) in the nasal turbinates and lungs of chickens infected with H7N1 HPAI virus. Chickens were classified as resilient or susceptible based on clinical signs, histopathological lesions, viral antigen detection, and viral shedding. Resilient chickens showed a distinct early transcriptional profile characterized by differential expression of genes related to MAPK signaling (CAV1), cell adhesion (ITGB1, PARVA), immune response (RELA), and antiviral response pathways (BID, CASP1, RAB2B). Critically, transcriptomic profiles of resilient birds differed markedly not only from susceptible birds but also from controls, consistent with viral exposure and an active host response. Our results suggest that the nasal mucosa is an important site in which early host responses are associated with divergent disease outcomes following HPAI viral infection. - Source: PubMed
Publication date: 2026/03/20
Valdez-May María JNofrarías MiquelPina-Pedrero SoniaDabad MarcValle RosaPérez MartaEsteve-Codina AnnaArgilaguet JordiMajó NatàliaBertran Kateri - The chemical composition of the ethyl acetate fraction extract of was tentatively characterised using LC-MS/MS-Q-TOF, resulting in the identification of 27 phytochemicals. Integrated network pharmacology and molecular docking analyses predicted that kaempferol-3,7-di---D-glucoside, procyanidin B2, prunin, and quercetin-3---L-rhamnoside may be associated with anti-inflammatory activity through potential interactions with inflammation-related targets, including PTK2B, PPARG, SIRT1, JAK2, IL6, TNF, and CAV1. The predicted signaling pathways potentially involved in the anti-inflammatory effects of include the PI3K-Akt signalling pathway, the MAPK signalling pathway, and the TNF signalling pathway. evaluation demonstrated that the ethyl acetate fraction of inhibited NO production in LPS-stimulated RAW 264.7 macrophages, with an IC value of 37.19 ± 1.89 μg/ml, providing preliminary experimental support for its anti-inflammatory potential. - Source: PubMed
Publication date: 2026/04/16
Truong Minh-NhutNguyen Duc-TuanPhan-Van Ho-NamNguyen-Huu Lac-Thuy - Alzheimer disease (AD) is a progressive neurodegenerative disorder marked by transcriptomic alterations affecting multiple genes. Many researchers have tried to predict major hallmarks of AD pathogenesis for diagnosis but the association between receptor tyrosine kinase (RTK) pathways and AD diagnosis is still unclear. This study aims to identify RTK-associated gene signatures crucial to AD pathogenesis and assess their potential as diagnostic biomarkers for AD. The study investigated changes in RTK pathway gene expression related to AD by analyzing brain transcriptome data from two independent public data sets (GSE84422 and GSE109887). Differentially expressed genes (DEGs) were analyzed from the GSE84422 and GSE109887 data sets and overlapping genes (oDEGs) were identified. RTK-related genes (ooDEGs) were subsequently selected through functional enrichment analysis. These were further refined into AD-related genes (disease-associated genes (DAGs)) through protein-protein interaction network analysis. Logistic regression and receiver operating characteristic analyses were conducted on the selected DAGs to evaluate their diagnostic potential, with additional gene expression validation performed in brain organoids and primary neurons. A total of 145 genes were identified as oDEGs in the above two data sets, and 18 genes were selected as ooDEGs. Six DAGs (ITGB1, AXL, GFAP, NRG1, CAV1, and RHOA) were selected. The diagnostic powers of the six DAGs for AD were 0.825 (GSE84422) and 0.884 (GSE109887). Human brain organoids and primary neuronal models were used to validate the biological relevance of these findings. AXL and ITGB1 were finally selected as key genes for RTK pathway in AD and were significantly increased in AD. - Source: PubMed
Publication date: 2026/04/15
Shin SaewoonZhu XiaohuiAmartumur SarnaiLee TaehoonYu Won JongPark SoominEtemadi NiloofarJamsranjav AriunzayaKang RianBak GyusooLee DongjoonKim JieunHan Jong WonHeo ChaejeongCho HansangChang SunghoeMook-Jung InheeLee Sang-EunPark Jong-Chan - Glioblastoma (GBM) is an incurable tumor where temozolomide (TMZ) resistance limits survival, even in MGMT-methylated patients. To improve stratification, we used NAD(P)H-FLIM to profile TMZ response in 35 patient-derived explants, integrating these data with transcriptomic and functional analyses. We identified BIRC3 and CAV1 upregulation in resistant tumors and investigated their parallel yet functionally cooperative role in driving an aggressive, therapy-resistant phenotype. In silico survival analyses demonstrated that BIRC3 and CAV1 act as independent prognostic factors whose additive, non-linear effects robustly stratify patient survival beyond MGMT status, defining a subgroup with <7% 24-month survival. Importantly, BIRC3/cIAP2-driven resistance proved targetable; the IAP antagonist AZD5582 restored TMZ sensitivity by unlocking the apoptotic execution phase, thereby inducing cell death in resistant GBM models in vitro and ex vivo. Our findings establish the BIRC3/CAV1 axis as a key prognostic signature and therapeutic vulnerability in GBM, offering a new path for precision oncology strategies. - Source: PubMed
Publication date: 2026/04/14
Franceschi SaraMorelli MariangelaLessi FrancescaDi Lorenzo FrancescaAretini PaoloPastore AldoMarranci AndreaGambacciani CarloPieri FrancescoVillanacci FedericoMontemurro NicolaGiacomarra ManuelMenicagli MicheleFerri GianmarcoPasqualetti FrancescoKrengli MarcoSanson MarcPicca AlbertoDi Stefano Anna LuisaSantonocito Orazio SantoMazzanti Chiara Maria