Recombinant Human Ubiquitin Conjugating Enzyme E2D1 UBE2D1
- Known as:
- Recombinant Human Ubiquitin Conjugating Enzyme E2D1 UBE2D1
- Catalog number:
- enz-116
- Product Quantity:
- 5
- Category:
- -
- Supplier:
- Prospecbio
- Gene target:
- Recombinant Human Ubiquitin Conjugating Enzyme E2D1 UBE2D1
Related genes to: Recombinant Human Ubiquitin Conjugating Enzyme E2D1 UBE2D1
- Gene:
- UBE2D1 NIH gene
- Name:
- ubiquitin conjugating enzyme E2 D1
- Previous symbol:
- SFT
- Synonyms:
- UbcH5A, UBCH5, UBC4/5, E2(17)KB1
- Chromosome:
- 10q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-03-21
- Date modifiied:
- 2016-03-14
Related products to: Recombinant Human Ubiquitin Conjugating Enzyme E2D1 UBE2D1
Related articles to: Recombinant Human Ubiquitin Conjugating Enzyme E2D1 UBE2D1
- Systemic juvenile idiopathic arthritis (sJIA) is an autoinflammatory disorder characterized by systemic immune dysregulation, yet reliable biomarkers to predict its unpredictable disease course are lacking. Identifying immune cell subsets and molecular drivers of disease progression is essential for improving prognosis and developing targeted therapies. Here, we performed comprehensive immunophenotypic profiling of PBMCs from sJIA patients across five clinical centers. We identified an unrecognized CD14CXCL10 monocyte subset in sJIA distinguished by a unique transcriptomic signature enriched in immune regulatory genes. Deconvolution analysis with longitudinal follow-up in the Chongqing cohort revealed a previously unrecognized CD14CXCL10 monocyte subset that was markedly expanded during active sJIA and diminished during remission, correlating strongly with disease activity. Flow cytometry confirmed its dynamic changes, and inflammatory stimulation promoted the differentiation of monocytes into the CXCL10 phenotype. To validate these observations , we used Ube2d1 knockout mice, which exhibit impaired CXCL10 induction and attenuated arthritis severity, highlighting the pivotal role of Ube2d1 in driving this inflammatory program. Furthermore, a cross-disease single-cell reference atlas demonstrated that this monocyte subset displayed a distinct expression profile in sJIA compared with other JIA subtypes and inflammation-related diseases. Collectively, our findings indicate that UBE2D1-driven CD14CXCL10 monocytes are central to sJIA pathogenesis and may represent both a biomarker and a therapeutic target for disease monitoring and intervention. - Source: PubMed
Publication date: 2025/11/19
Luo QiangYang JunYu HaiguoHao HanWu XinglinLuo XiwenMa MingshengYang XiZhang ZhiyongAn YunfeiZhao XiaodongSong HongmeiTang Xuemei - Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy with poor clinical outcomes. Ubiquitin-conjugating enzyme E2 D1 (UBE2D1), a key component of the ubiquitination machinery, has been implicated in tumor progression in several cancers; however, its relevance in HNSCC remains unclear. This study aimed to investigate UBE2D1 expression in HNSCC, evaluate its prognostic significance while acknowledging disease heterogeneity, including HPV and TP53 status, and explore its potential association with response to anti-PD-1 immunotherapy. - Source: PubMed
Publication date: 2026/02/14
Prasad PrathibhaArumugam Paramasivam - Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer. Fingolimod (FTY720) is a sphingosine-1-phosphate (S1P) receptor agonist that prevents lymphocytes from egressing from lymphoid tissues and has shown a cytotoxic effect on T-cell ALL (T-ALL) cells. However, the mechanism of action of FTY720 cytotoxicity in hematological malignancies is still unclear, and cell-specific effects have been reported. Here, we investigated the mechanism of cytotoxicity of FTY720 in T-ALL cells using a CRISPR-Cas9 genomic screening. Our goal was to identify novel positive regulators for the cytotoxic effect of FTY720 in T-ALL. - Source: PubMed
Publication date: 2026/01/23
Ferreira de Vasconcellos JairaFriedman LeahSatapathy IshaCubbage NicolePalmer JasminMajumder SauravKono Mari - Esophageal squamous cell carcinoma (ESCC) is a malignancy characterized by extensive epigenetic dysregulation. This study aims to develop a robust prognostic model utilizing epigenetic-related genes (ERGs) to improve survival prediction in ESCC patients, while simultaneously elucidating potential mechanisms underlying immune microenvironment modulation. - Source: PubMed
Publication date: 2025/10/23
Su YaniZhang MingZhang QiongWen PengfeiXu KeXie JialeWan XianjieLiu LinXu PengYang ZhiYang Mingyi - Sarcopenia (SARC) presents considerable challenges to the quality of life for the elderly and exerts a significant economic strain on healthcare systems. Contemporary therapeutic methods, such as physical activity, dietary supplementation, and medication, frequently demonstrate restricted effectiveness and significant individual variation. This study seeks to identify new therapeutic targets through the analysis of lysosomal autophagy-related differentially expressed genes (LARDEGs) associated with SARC. Differentially expressed genes(DEGs) related to SARC were identified through an extensive analysis of microarray datasets (GSE8479 and GSE1428) obtained from the Gene Expression Omnibus. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway analysis, protein-protein interaction (PPI) network analysis, and Gene Set Enrichment Analysis were used to assess the biological functions, molecular pathways, autophagy-related molecular markers, and immune microenvironment linked to SARC DEGs. Our findings identified 12 LARDEGs, including BHLHE41, HLTF, UBE2D1, UBE2D2, NPC1, NDRG1, SLC22A18, CDKN1A, CALCOCO2, SCARB2, LGALS1, and RPS27A, that were significantly correlated with energy metabolism and mitochondrial function. We constructed a PPI network that identified six crucial hub genes: BHLHE41, UBE2D1, UBE2D2, CDKN1A, SCARB2, and RPS27A. This network provides significant insights into their functional roles and their potential as therapeutic targets. Additionally, an examination of immune infiltration demonstrated significant differences in the quantities of resting natural killer (NK) cells and M2 macrophages between SARC samples and control samples. CDKN1A displayed a positive correlation with M2 macrophages and an inverse relationship with resting NK cells. The results show how important the immune microenvironment is to the spread of SARC, suggesting promising pathways for the creation of immunotherapeutic strategies. Our research elucidates the molecular pathways implicated in SARC and establishes a foundation for future therapeutic approaches. However, additional validation is crucial to translating these findings into viable clinical applications. - Source: PubMed
Publication date: 2025/10/22
Zhou YeQian YueYuan XinZhu Qingqing