Recombinant Human 6-Phosphogluconolactonase PGLS
- Known as:
- Recombinant Human 6-Phosphogluconolactonase PGLS
- Catalog number:
- enz-016
- Product Quantity:
- 2
- Category:
- -
- Supplier:
- Prospecbio
- Gene target:
- Recombinant Human 6-Phosphogluconolactonase PGLS
Related genes to: Recombinant Human 6-Phosphogluconolactonase PGLS
- Gene:
- PGLS NIH gene
- Name:
- 6-phosphogluconolactonase
- Previous symbol:
- -
- Synonyms:
- 6PGL
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-01-20
- Date modifiied:
- 2015-08-25
Related products to: Recombinant Human 6-Phosphogluconolactonase PGLS
Related articles to: Recombinant Human 6-Phosphogluconolactonase PGLS
- Investigating the evolution of functional genes in non model plants is often hindered by the lack of reference genomes and transcriptomic resources, especially for taxa inhabiting extreme environments. Here, focusing on the salidroside biosynthesis pathway in the medicinal alpine genus Rhodiola, we asked whether genome skimming data could be used to test three a priori predictions: predominant purifying selection across most pathway genes, lineage specific shifts in selective constraint under heterogeneous environments, and corresponding differences in predicted protein binding properties. - Source: PubMed
Publication date: 2026/04/27
He HaoYang Fu-ShengZhang Yu-XiangXu ChaoMa Xin-TangSong Yong-XiuSun Jia-HuiYu Yan - Phaeochromocytomas (PCCs) and paragangliomas (PGLs), are rare neuroendocrine tumours that arise in the neural crest (NC)-derived adrenal medulla and the paraganglia, respectively. Approximately 10%-15% of patients with PCCs and 35%-40% with PGLs go on to develop metastatic disease, leading to a reported median overall survival of 7 years. The development of prognostic markers and subsequent personal therapeutic strategies are hindered by a lack of understanding of tumourigenesis. In other organs, cells with stem-like properties are at the root of tumour initiation and maintenance, due to their ability to self-renew and give rise to differentiated cells. We have recently shown that, in the human adrenal, a subset of sustentacular cells, endowed with a support role, are in fact SOX2+ postnatal adrenomedullary stem cells, that are specified along the neural crest migratory route. In this study, we intended to determine if SOX2+ cells in PCCs and PGLs can behave as tumour-initiating stem cells. Using expression and transcriptomic studies, we demonstrate the presence of SOX2/SOX2-expressing cells across a broad range of PCCs and PGLs, irrespective of tumour aggressiveness, location, and causative mutation. In silico analyses reveal the co-expression of SOX2 and chromaffin cell markers in the tumour, and the active proliferation of these double-positive cells. Isolation of these cells in vitro in stem cell-promoting media, and their xenotransplantation on chicken chorioallantoic membranes, demonstrates that they have the potential to expand and metastasise in ovo, supporting their potential as tumour-initiating cells. - Source: PubMed
Publication date: 2026/04/22
Kemkem YasmineQuinn MarkKövér BenceSantambrogio AliceKaufman-Cook JamesSherwin OliviaScriba Laura DBrempou DimitriaSegoviano Miriam VazquezCameron DylanBerger IlonaNg WenNonaka DaisukeTheodoropoulou MarilyPamporaki ChristinaCarroll Paul VIzatt LouiseChapple J PaulBornstein Stefan RBechmann NicoleSteenblock CharlotteOakey Rebecca JAndoniadou Cynthia L - Retroperitoneal paragangliomas (RP-PGLs) are rare extra-adrenal neuroendocrine tumors representing ~ 1-3% of retroperitoneal masses. They may secrete catecholamines, causing hypertension and life-threatening complications if untreated. Surgical resection is the mainstay of therapy, yet data-particularly from the Indian subcontinent-are scarce. To evaluate clinical presentation, diagnostic workup, perioperative management and long-term outcomes of RP-PGL resections at a tertiary oncology center. A retrospective analysis of 30 patients who underwent RP-PGL resection from 2005 to 2023 was done. Preoperative evaluation was based on standard institutional protocols after a multidisciplinary discussion. Data collected included operative time, blood loss, histopathology (tumor size, stage, margins, SDH/MEN mutations) and Clavien-Dindo morbidity. Overall survival (OS) and disease-free survival (DFS) were estimated via Kaplan-Meier analysis. Median age was 44 years (range 22-66); 40% were male. Presentations: pain (56.7%), incidental mass (23.3%), classical symptoms (6.7%). Half had secretory tumors; 40% of these exhibited uncontrolled hypertensions. R0 resection was achieved in 73.3%, including 13.3% multivisceral/vascular resections. SDH and MEN mutations were found 16.7%, and 3.3% respectively. Postoperative morbidity ≥Clavien-Dindo IIIa occurred in 16.7%, with no 90-day mortality. At a median follow-up of the 36.9 months (95% C.I: 10.9 to 62.8 months), median OS and DFS were not reached and the 3-year Overall survival (OS) and 3-year disease free survival (DFS) was 95.5% (91.1 to 99.9%) and 89.1% (81.6 to 96.6%) respectively. Three recurrences occurred; two responded to peptide receptor radionuclide therapy. Surgical management of RP-PGLs is safe and achieves excellent long-term survival. A standardized diagnostic algorithm, multidisciplinary perioperative optimization and readiness for complex resections are key to favorable outcomes. - Source: PubMed
Publication date: 2026/03/17
Devi YaliniShah Tanvi MKazi MufaddalPatkar ShraddhaKaushal Rajiv KumarGala KunalGoel Mahesh - Caudata (salamanders) is a highly threatened taxonomic group with over 60% of species estimated to be threatened. However, the species traits and extrinsic factors underlying their population decline and high extinction risk remain unclear. We conducted the first global comparative analysis to investigate which factors are associated with an increased risk of decline and extinction in salamanders. We addressed the following questions: Is extinction risk randomly distributed among salamander families, and if not, which families contain more threatened species than would be expected by chance; which species traits and extrinsic factors are important in determining the extinction risk in salamanders; and are the key factors for population decline consistent with those for extinction risk in salamanders? To determine which ecological characteristics and extrinsic factors best predict extinction risk and population decline in salamanders, we employed phylogenetic generalized least squares (PGLS) models and phylogenetic logistic regression (PGLM) models, respectively. Threatened salamanders were nonrandomly distributed across nine families, among which Cryptobranchidae and Hynobiidae contained significantly more threatened species than expected. Key predictors of salamander extinction risk were breeding strategy, geographic range size, minimum elevation, human threat index, and protected area coverage. Although geographic range size, climate change, and human threats were the most important predictors of salamander extinction risk and population decline, the effect of geographic range size was the opposite between the PGLS and PGLM models. Our results suggest that priority management should focus on extinction-prone families, particularly Cryptobranchidae and Hynobiidae, and salamanders with small range sizes and sensitivity to human disturbance or climate instability. - Source: PubMed
Publication date: 2026/04/19
Wang JiangChen ChuanwuZhang YuyangWang Yanping - Mediastinal paragangliomas (PGLs) are extremely rare neuroendocrine tumors. Clinical presentation varies and tumor resection can be challenging due to bleeding and risk of catecholamine surges in functional tumors. We report on a case 68 with a DOTATATE avid mediastinal mass which was histopathologically confirmed as a PGL that was fed by the coronary artery in whole-body positron emission tomography/computed tomography imaging using gallium-68-DOTATATE. - Source: PubMed
Publication date: 2026/04/13
Okudan BernaYükseltürk RefiaÖzdemir Mustafa