Recombinant Human Hydroxyacylglutathione Hydrolase HAGH
- Known as:
- Recombinant Human Hydroxyacylglutathione Hydrolase HAGH
- Catalog number:
- enz-034
- Product Quantity:
- 2
- Category:
- -
- Supplier:
- Prospecbio
- Gene target:
- Recombinant Human Hydroxyacylglutathione Hydrolase HAGH
Related genes to: Recombinant Human Hydroxyacylglutathione Hydrolase HAGH
- Gene:
- HAGH NIH gene
- Name:
- hydroxyacylglutathione hydrolase
- Previous symbol:
- -
- Synonyms:
- GLO2, GLXII, HAGH1
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2015-08-25
Related products to: Recombinant Human Hydroxyacylglutathione Hydrolase HAGH
Related articles to: Recombinant Human Hydroxyacylglutathione Hydrolase HAGH
- Epilepsy is a common neurological disorder with high genetic heterogeneity and affects approximately 70 million people worldwide. Although several studies have combined Genome-Wide Association Studies (GWAS) with bulk expression quantitative trait loci (eQTLs) to explore epilepsy risk genes, the cellular context of genetic regulation remains insufficiently defined. - Source: PubMed
Publication date: 2026/04/21
Zhong Gao-YangLiu CongWang Hui-LingLiang ManLiu Zi-Long - Long COVID is a complex condition where symptoms persist for more than 3 months after SARS-CoV-2 infection and affects an estimated 5-30% of individuals. While persistent inflammation has emerged as an important feature of this condition, it is unclear if immune responses from COVID-19 vaccination or SARS-CoV-2 re-infection exacerbate or mirror the initial inflammatory responses. - Source: PubMed
Publication date: 2026/04/13
Bansal AmitOlechnowicz Sam W ZKiernan-Walker NicholasCumming JacobAbdul Azeez ImadhMazhari Ramin Cox Rebecca JMueller IvoBowden RoryEriksson Emily M - Mitochondrial dysfunction contributes critically to epileptogenesis. Therefore, identifying key mitochondrial function-associated genes in epilepsy may provide novel insights into its pathogenesis. We employed expression quantitative trait loci (eQTLs) and Mendelian randomization analyses to assess mitochondrial-epilepsy causality, with leave-one-out validation confirming the reliability and directionality of the results. The results revealed that hydroxyacylglutathione hydrolase (HAGH), oxysterol-binding protein-related protein 1A (OSBPL1A) and pantothenate kinase 2 (PANK2) were pivotal epileptogenic genes. HAGH modulates the mechanistic target of rapamycin complex 1 (mTORC1) signaling and fatty acid metabolism pathways. OSBPL1A mediates apoptotic and reactive oxygen species (ROS) pathways. PANK2 regulates phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling and Notch signaling cascades. Additionally, these genes participate in inflammatory pathways, including T cell receptor (TCR), mitogen-activated protein kinase (MAPK), and tumor necrosis factor (TNF) signaling. We demonstrated that HAGH, OSBPL1A, and PANK2 constitute core pathogenic mechanisms in epilepsy. These genes potentially govern epileptogenesis through mitochondrial regulation via neuroinflammatory, immunomodulatory, and apoptotic pathways. Our findings provide a foundation for investigating epileptogenesis, discovering therapeutic targets, and identifying prognostic biomarkers. - Source: PubMed
Publication date: 2026/03/09
Zhang Lin-MingWang FeiZhang Bing-RanZhang Qiu-JuanZhu Yan-LinGao Shu-JiWang HaoLiu Ming-Wei - This study aimed to histopathologically compare the efficacy of 5% melatonin (MEL) gel and 1.2% rosuvastatin (RSV) gel on bone regeneration in rat calvarial defects. - Source: PubMed
Publication date: 2025/12/30
Hagh Leila GolpasandRahimi NeginRezaie AnnahitaYousefimanesh HojatollahSamie Neda - Critically elastic materials-those that are rigid with a single state of self-stress-can be generated from parent systems with two states of self-stress by the removal of one of many constraints. We show that the elastic moduli of the resulting homogeneous and isotropic daughter systems are interrelated by a universal functional form parametrized by properties of the parent. In simulations of both spring networks and packings of soft spheres, judicious choice of parent systems and bond removal allows for the selection of a wide variety of moduli and Poisson's ratios in the critically elastic systems, providing a framework for versatile deterministic selection of mechanical properties. - Source: PubMed
Jeon HongryolSadjadi MahdiHagh Varda F