FOXN1, affinity purified antibody, goat, 100 ug.
- Known as:
- FOXN1, antigenic enriched (anti-), caprine, 100 ug.
- Catalog number:
- GT41016-100
- Category:
- -
- Supplier:
- Neuromi
- Gene target:
- FOXN1 affinity purified antibody goat 100 .
Related genes to: FOXN1, affinity purified antibody, goat, 100 ug.
- Gene:
- FOXN1 NIH gene
- Name:
- forkhead box N1
- Previous symbol:
- WHN, RONU
- Synonyms:
- FKHL20
- Chromosome:
- 17q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-07
- Date modifiied:
- 2019-04-23
Related products to: FOXN1, affinity purified antibody, goat, 100 ug.
Related articles to: FOXN1, affinity purified antibody, goat, 100 ug.
- The Forkhead box (Fox) transcription factors are evolutionarily conserved regulators of development, cell cycle, and apoptosis across metazoans. This study provides the first comprehensive genome-wide analysis of the Fox gene family in the Asian green mussel (Perna viridis). We identified 28 Fox genes distributed across 10 chromosomes. Comparative analysis reveals the absence of the FoxI, FoxQ1, FoxR and FoxS subfamily, consistent with other bivalves and indicative of lineage-specific gene loss during molluscan evolution. Notably, gene duplications in the FoxAB, FoxD, FoxH, FoxN1-4, FoxQ2 and FoxQD subfamilies may reflect functional diversification associated with environmental adaptation. Exon-intron structural variability, including intron loss in several paralogues, suggests structural diversification and potential regulatory variation. Phylogenetic reconstruction confirmed the monophyly of core Fox classes while highlighting divergent expansion patterns in lophotrochozoans. Selection analyses showed strong purifying selection across duplicated Fox paralogs, supporting functional conservation after lineage-specific expansion. Gene Ontology enrichment linked Fox genes to stress response, apoptosis, and transcriptional regulation. By integrating phylogenetic, structural, and transcriptomic analyses, this study provides a genomic framework for understanding Fox gene organisation, evolution, and tissue-associated expression patterns in Perna viridis and establishes a comparative resource for future functional studies in bivalves. - Source: PubMed
Publication date: 2026/06/08
Vysakh V GSukumaran SandhyaGopalakrishnan A - Psmb11-encoded β5t is a proteolytic subunit of thymoproteasomes expressed in cortical thymic epithelial cells (cTECs). β5t-containing thymoproteasomes are essential for the thymic generation of CD8-lineage cytotoxic T cells. Here, we outline the current understanding of the mechanisms underlying thymoproteasome-dependent CD8 T cell development. We focus on the cTEC-specific expression of β5t, highlighting its unique expression in comparison with the transcription factor Foxn1, which is expressed in both thymic and skin epithelial cells. Additionally, we discuss our recent engineering of monoclonal antibodies that are specific for mouse and human β5t. β5t not only provides an important machinery for CD8 T cell development but also serves as a valuable tool for further study of the biology of thymic epithelial cells in health and disease. - Source: PubMed
Publication date: 2026/06/09
Yang Mei-TingShimizu AkihideMatsuda-Lennikov MamiLi JieGluckman MelecaJacques AlisonMurata ShigeoRoberts Rhonda RCaceres Tessa WGarcia-Buntley Sandra SColantonio SimonaTakahama Yousuke - To investigate the effect of on thymic cortical regeneration in rapamycin-treated mice and its underlying mechanisms. - Source: PubMed
Publication date: 2026/06/08
Xu XieShu YaoyingGao Jianli - Androgenetic alopecia (AGA) is characterized by progressive hair follicle miniaturization driven by premature follicle regression. While extracellular vesicles (EVs) are potent bioactive therapeutics, their clinical translation is hindered by the low yields and poor stability of mammalian-derived sources. Herein, we developed an injectable biomacromolecular hydrogel composed of sodium carboxymethylcellulose (CMCNa), sodium alginate (SA), and hyaluronic acid (HA) to deliver plant-derived Poria cocos extracellular vesicles (PCEVs) for the topical treatment of AGA. This polysaccharide matrix was engineered to localize vesicular cargo within the follicular niche, preserve vesicle integrity, and facilitate the sustained release of PCEVs. The hydrogel exhibited favorable rheological properties, injectability, and cytocompatibility for topical application. In a dihydrotestosterone (DHT)-induced AGA mouse model, topical administration of the PCEV-loaded hydrogel significantly accelerated hair regrowth, enhanced follicle density, and restored hair bulb volume and dermal thickness. Transcriptomic profiling revealed that the therapeutic effect was driven by Wnt/β-catenin signaling activation. Specifically, PCEVs treatment led to the upregulation of differentiation markers homeobox C13 (Hoxc13) and forkhead box N1 (Foxn1), hair-shaft keratin Krt31, and desmoglein 4 (Dsg4), along with the downregulation of stem-cell quiescence markers nuclear factor of activated T cells 1 (Nfatc1) and Cd34. Collectively, this delivery platform effectively leverages plant-derived EV cargo to reverse stem-cell quiescence and promote follicular regeneration, offering a scalable and stable translational strategy for hair loss disorders. - Source: PubMed
Publication date: 2026/05/15
Luo HuitingWang ShangWang HantaoGeng XinxinXu QinyiYe LinglingYang LiXiang WeiWang JianweiLi ChunliKe Dazhi - Adipocyte depots throughout the body are physiologically and molecularly distinct. With age, adipocytes increase in and around aged thymi. However, thymic adipocytes completely lack molecular characterization. We developed and optimized methods to isolate adipocyte nuclei from mouse thymi of different ages and sexes. Single-nucleus multiomic analysis of male and female mice aged 4-9 months reveals that thymic adipocytes are heterogeneous, with at least two distinct populations. One subpopulation harbors a transcription and chromatin signature consistent with beige/brown fat. A larger subpopulation more strongly resembles classic white adipose tissue and expresses genes associated with epithelial-to-mesenchymal transition (EMT) and antigen presentation. Analysis of differentially open chromatin in the white compared to beige adipose population identifies binding sites for Foxn1 and HIF-1a/Arnt, consistent with a situation in which thymic white adipose cells emerge from thymic epithelial cells, possibly under hypoxic conditions. Immunofluorescence microscopy confirmed the expression of UCP1 protein in cells within the thymic parenchyma, most prominently in subcapsular cortical regions. This resource reveals a complex milieu of thymic adipocytes and identifies multiple avenues for directly probing their ontogeny, dynamics and functional significance. - Source: PubMed
Publication date: 2026/04/27
Schwakopf JoonSyage Amber RFranzini AncaVarley Katherine ETantin Dean