rR TNF-alpha
- Known as:
- rR TNF-a
- Catalog number:
- AK8320-1000
- Product Quantity:
- 1mg
- Category:
- -
- Supplier:
- Akro
- Gene target:
- TNF-alpha
Related products to: rR TNF-alpha
Related articles to: rR TNF-alpha
- Type 1 diabetes (T1D) risk variants within influence transcript splicing and alter the expression of signal regulatory protein gamma (SIRPγ) on human T cells; however, the functional consequences of the risk variants remain poorly defined. Here, we demonstrate that peripheral blood mononuclear cells from individuals carrying a T1D-associated risk haplotype exhibit increased membrane-bound SIRPγ and reduced expression of its ligand CD47 across CD4 and CD8 T cell subsets compared to a protective haplotype. To interrogate the impact of impaired CD47 signaling, we generated CRISPR/Cas9 knockout (KO) models in Jurkat and primary human CD8 T cells, as well as a pancreatic β-cell line (βLox5). -deficient T cells displayed heightened activation, reduced co-inhibitory receptor expression, and increased production of IL-2 and TNF following stimulation. Furthermore, KO CD8 T cell avatars expressing an HLA-A*02:01-restricted, IGRP-reactive T cell receptor (TCR) exhibited enhanced cytotoxicity toward βLox5 targets, while KO βLox5 cells were more susceptible to apoptosis. These findings reveal that CD47 signaling constrains T cell effector function and β-cell susceptibility, and its disruption through altered SIRPγ-ligation may contribute to autoimmune pathogenesis in T1D. - Source: PubMed
Publication date: 2026/10/01
Sharp Robert CBrown Matthew EPeters Leeana DBacher RhondaJacobsen Laura MBrusko Todd M - Obesity and its associated metabolic disorders pose significant global health challenges. This study investigated the anti-obesity effects of Akkermansia muciniphila HHAKKα in high-fat diet (HFD)-induced obese mice. C57BL/6J mice were administered HHAKKα orally for 8 weeks while maintained on HFD. Results demonstrated that HHAKKα significantly inhibited weight gain (5.76 g vs. 10.79 g in HFD group), with efficacy comparable to orlistat. HHAKKα intervention effectively maintained glucose homeostasis, decreased serum triglycerides and LDL-cholesterol levels, and elevated adiponectin and GLP-1 levels. Furthermore, HHAKKα significantly reduced pro-inflammatory cytokines (TNF-α, IL-1β, MCP-1) and alleviated hepatic steatosis and adipocyte hypertrophy. Mechanistically, HHAKKα modulated gut microbiota composition, increasing beneficial bacteria (Akkermansia, Roseburia, Eubacterium) while decreasing the Bacillota/Bacteroidota ratio by 55.35%. Notably, the HHAKKα intervention significantly enhanced fecal short-chain fatty acids (SCFAs) production-particularly butyrate, which was restored to approximately 1.5 times its normal level-and this effect correlated negatively with serum lipid levels and inflammatory markers. Molecular analysis revealed that HHAKKα regulated hepatic lipid metabolism by inhibiting FASN expression and upregulating PGC-1α. These findings suggest that A. muciniphila HHAKKα ameliorates HFD-induced obesity through a multi-faceted mechanism involving gut microbiota modulation, SCFA production enhancement, inflammation suppression, and hepatic lipid metabolism regulation, highlighting its therapeutic potential for obesity management. - Source: PubMed
Zhou GuiqiuChen MenglingZhao LinglingLiu FeitongYue ZhongbaoZhao JingqiRen Dayong - Yoga, a holistic mind-body practice used to improve physical function and psychological well-being in chronic inflammatory conditions such as rheumatoid arthritis (RA). This systematic review and meta-analysis aimed to assess the effectiveness of yoga in reducing psychological function and inflammation in individuals with RA. - Source: PubMed
Suresh AbinayaRamaswamy ShobanaSilambanan SanthiKuppusamy Mahesh Kumar - Thermal waters and peloid-derived products have long been used in dermatological and spa treatments, although the cellular mechanisms underlying their biological effects remain incompletely characterized. This study investigated the effects of Saturnia spa water (TW) and an aqueous mud extract (MUD) on inflammatory, redox, and wound-healing responses in human skin cell models. - Source: PubMed
Costantini EricaPellacani GiovanniShahzadi ChmanReale MarcellaKanwal ShamsaTafuri GiuseppeScaramuzzino ManelaViseras CésarSinjari Bruna - Ulcerative colitis (UC) treatment has emerged as a worldwide healthcare challenge. Despite its anti-inflammatory properties, there are few reports on the Matricaria chamomilla L. essential oil (MEO) for the repair of UC. This study aims to extract natural MEO, prepare the self-microemulsion drug delivery system (SMEDDS) to improve the solubility and stability of MEO, and investigate its repair effects on UC. - Source: PubMed
Publication date: 2026/10/02
Rong WanjingAdu-Frimpong MichaelChen HongZhu SuqiWang ZheBerdiyar JollibekovWang QilongYu JiangnanXu Ximing