rHu MIP-1-alpha
- Known as:
- rHu MIP-1-a
- Catalog number:
- AK8250-0020
- Product Quantity:
- 20
- Category:
- -
- Supplier:
- Akro
- Gene target:
- rHu MIP-1-alpha
Related products to: rHu MIP-1-alpha
Related articles to: rHu MIP-1-alpha
- Sepsis recognition in the ICU remains variable and relies on consensus clinical criteria rather than biomarker-defined rules. Routine laboratory and physiologic data often overlap with noninfectious critical illness, obscuring early identification. We evaluated whether discovery proteomics could prioritize a concise set of routinely obtainable clinical variables, yielding a practical, clinic-first model that distinguishes sepsis from other critical illness. - Source: PubMed
Publication date: 2026/03/14
Ardabili A KhaleghiRice SSamuelsen ABrown Ruth-AnnBonavia Anthony S - The long asymptomatic period of clear cell renal cell carcinoma, which leads to delayed diagnosis and poorer prognosis, poses a global challenge. Chemokines play a pivotal role in immune regulation and tumor progression, making them promising biomarker candidates. This study aimed to evaluate the usefulness of the C-C motif chemokine ligand 3 (CCL3) and C-C motif chemokine ligand 7 (CCL7) by assessing their serum concentrations in 40 patients with stage G1 + G2 and stage G3 + G4 renal cancer, as well as in 58 healthy volunteers. Chemokine concentrations were measured using a multiplex Luminex assay and analyzed statistically, including receiver operating characteristic (ROC) analysis. Serum CCL3 concentrations were significantly elevated in ccRCC patients compared to controls and increased with tumor grade, with the highest levels observed in patients with advanced disease (G3+G4). In contrast, serum CCL7 levels were significantly lower in ccRCC patients than in healthy individuals, with no significant differences between tumor grade subgroups. ROC analysis revealed comparable diagnostic performance of CCL3 and CCL7, with CCL3 showing a slightly higher area under the curve. CCL3 showed high sensitivity, whereas CCL7 exhibited higher specificity than sensitivity, and a relatively high positive predictive value, consistent with its inverse regulation in ccRCC. These findings suggest that serum CCL3 and CCL7 are oppositely regulated in ccRCC and may serve as complementary non-invasive biomarkers for renal cancer detection. - Source: PubMed
Publication date: 2026/03/08
Sokólska WeronikaZajkowska MonikaKulczyńska-Przybik AgnieszkaWerel TadeuszOrywal Karolina - Leishmania donovani can cause visceral leishmaniasis, clinically manifested as fever, hepatosplenomegaly, and anemia. If left untreated, it may lead to death owing to complications from other diseases and infections. However, the pathogenesis of L. donovani infection remains unclear. - Source: PubMed
Publication date: 2026/03/13
Li Fei-RanSun QiWang QingQu Ling-LinLi Zhi-HuiYi Zheng-JunYang Bin-Bin - Psychosocial stress is associated with increased risk for hypertensive disorders of pregnancy (HDP), and inflammation may be a key pathway mediating this association. However, few studies have examined maternal-fetal inflammation during mid-pregnancy. - Source: PubMed
Publication date: 2026/03/12
Eick Stephanie MOrtlund KaeganDunlop Anne LLi LinMorello-Frosch RachelWoodruff Tracey JGaw Stephanie LBrennan Patricia ALiang DonghaiBarr Dana BoydRobinson Joshua FGoin Dana E - Viral reservoir presents a significant challenge in HIV-1 cure. We previously observed that Thymosin α1 (Tα1) may restrict the reservoir through the IL-15 pathway. However, the precise mechanism remains to be fully elucidated. Peripheral blood mononuclear cells (PBMCs) were obtained from people living with HIV-1 (PLWH). In vitro, THP-1 cells were differentiated into mature monocyte-derived dendritic cells (MoDCs) and co-cultured with PBMCs under various conditions. Intracellular HIV-1 p24 levels, CD8+ T and NK cell functionality, and reservoir size were evaluated. In vitro, Tα1 stimulation of MoDCs resulted in significant immune response and secretion of IL-15/RA complex ( < 0.001). This interaction with IL-2 Rβ/γ receptors on T cells enhanced the intracellular secretion of CCL3/5, IFN-γ, and TNF-α in CD8+ T cells ( < 0.05), which inhibited p24 levels in CD4+ T cells ( = 0.002), and reduced HIV-1 integrated DNA levels ( = 0.012). Furthermore, the secretion levels of IFN-γ, TNF-α and GZMB in NK cells and proportion of CD8+ T cells significantly increased following co-culture. These alterations were found to be markedly inversely associated with reservoir size and reactivation. However, these effects were observed in PBMCs from immunological responders (CD4+ T cell count > 350 cells/µL) rather than nonresponders. Tα1 enhances CD8+ T cell function, promotes T proliferation, and suppresses reservoir size and reactivation via IL-15 pathway activation in dendritic cells, which warrants testing in functional cure trials in the future. - Source: PubMed
Publication date: 2026/03/13
Chen ChaoyuXun JingnaWang JiangrongZhang RenfangQi TangkaiLiu LiZhang XinyuSong ZichenShen YinzhongLu HongzhouChen Jun