TNFSF13B (Human) Matched Antibody Pair ab pairs
- Known as:
- TNFSF13B (Human) Matched Antibody Pair ab pairs
- Catalog number:
- 'H00010673-AP11
- Product Quantity:
- 1 set
- Category:
- -
- Supplier:
- ACR
- Gene target:
- TNFSF13B (Human) Matched Antibody Pair pairs
Related genes to: TNFSF13B (Human) Matched Antibody Pair ab pairs
- Gene:
- TNFSF13B NIH gene
- Name:
- TNF superfamily member 13b
- Previous symbol:
- TNFSF20
- Synonyms:
- BAFF, THANK, BLYS, TALL-1, TALL1, CD257
- Chromosome:
- 13q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-19
- Date modifiied:
- 2018-11-22
Related products to: TNFSF13B (Human) Matched Antibody Pair ab pairs
Related articles to: TNFSF13B (Human) Matched Antibody Pair ab pairs
- SERPING1, which encodes the C1 inhibitor (C1-INH) of the complement system, and plays a key regulator in regulating inflammatory responses and immune homeostasis. SERPING1 is downregulated in various disease, this downregulation occurs through the body's negative feedback resulting from the overactivation of the complement system in diseases such as infections and acute inflammatory responses. Additionally, SERPING1 is vital for tumor immunomodulation. Diffuse large B-cell lymphoma (DLBCL) is a common and aggressive type of non-Hodgkin lymphoma. More treatment options are becoming available for this disease. However, some patients still experience recurrence or even disease progression during treatment. Consequently, elucidating the molecular underpinnings of DLBCL's malignant behavior and identifying novel prognostic markers and therapeutic targets are paramount for improving patient outcomes. - Source: PubMed
Publication date: 2026/06/03
Wang JinhuiLi ZhihuiZhan XinrongZhang YanpingWang ZhongliangXing PengtaoLiu MengmengGuo MengyiXu KailiWang Haoyan - Ovarian cancer (OVCA) remains the most lethal gynecologic malignancy, with poor prognosis largely due to late-stage diagnosis and therapy resistance. Pyroptosis, a pro-inflammatory form of programmed cell death, has recently emerged as a regulator of tumor progression and immune regulation. This study aimed to systematically profile pyroptosis-related genes and identify robust biomarkers for OVCA. Microarray data from the GSE54388 dataset were analyzed to characterize pyroptosis-related gene expression. Immune cell infiltration was assessed using xCell, and pathway enrichment was performed via Gene Set Enrichment Analysis (GSEA). Weighted Gene Co-expression Network Analysis (WGCNA) identified hub genes, followed by Gene Ontology (GO) and Reactome enrichment. Machine learning algorithms (Support Vector Machine, XGBoost, and Generalized Linear Model) were employed for feature selection and biomarker identification. Validation was conducted across independent bulk and scRNA-seq datasets, with GEPIA2 used to compare OVCA and normal samples and KMplot for survival analysis. OVCA samples showed significantly reduced infiltration of CD4 and CD8 T cells, mast cells, monocytes, neutrophils, and immature dendritic cells compared to normal samples. GSEA revealed enrichment of cell cycle-related pathways, implicating pyroptosis-related genes as key regulators of mitotic progression. From 1097 differentially expressed genes, 22 pyroptosis-related DEGs (PYRDEGs) were identified, with nine hub genes (CASP1, CEP55, CHMP4C, HTRA1, IL18, MELK, PKM, PTX3, TNFSF13B) strongly associated with OVCA. Functional enrichment linked these genes to cytokinesis, inflammasome activity, and immune signaling. Machine learning consistently identified CEP55 as the core biomarker, demonstrating high diagnostic accuracy (AUC up to 0.972) and significant upregulation in OVCA samples. Correlation analysis linked CEP55 expression to altered immune cell populations, including positive associations with Th1 and class-switched memory B-cells and negative associations with iDCs, Tregs, and M2 macrophages. CEP55 was highly expressed across bulk and scRNA-seq datasets (cancer epithelial and CD8+ TEMRA cells) and negatively correlated with overall survival (OS) and progression-free survival (PFS). Pyroptosis-related genes play pivotal roles in OVCA pathogenesis. CEP55 emerges as a promising biomarker for early detection and a potential therapeutic target, bridging cell cycle regulation with immune modulation. - Source: PubMed
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Arya RakeshBiswas Viplov KumarShakya HemlataKim Jong-Joo - To examine B cell-activating factor (BAFF) and type I interferon (IFN) activity at the transcriptional and protein levels in blood and placental tissue in SLE compared with healthy pregnancies to assess their relationship and to determine whether BAFF levels are associated with pregnancy outcomes in SLE. - Source: PubMed
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Torell AgnesAndersson KerstinGunnarsson IvaSvenungsson ElisabetZickert AgnetaMajczuk Sennström MariaTrysberg EstelleBengtsson Anders AJönsen AndreasStrevens HelenaSjöwall ChristopherSaleh MunaPihl SofiaLeonard DagRonnblom LarsAkhter TansimRoshanzamir FaribaZetterberg HenrikBylund JohanJacobsson BoRudin AnnaLundell Anna-CarinStockfelt Marit - Clear cell renal cell carcinoma (ccRCC) is the most common histological type of RCC and is marked by aggressive nature and poor survival. However, therapeutic options remain limited and yield suboptimal outcomes. Macrophages exhibit marked heterogeneity within ccRCC, exerting a substantial impact on the malignant progression of tumors and resistance to therapeutics. - Source: PubMed
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