SLC12A2 antigen
- Known as:
- SLC12A2 antigenic
- Catalog number:
- 'H00006558-Q01-10
- Product Quantity:
- 10
- Category:
- -
- Supplier:
- ACR
- Gene target:
- SLC12A2 antigen
Related genes to: SLC12A2 antigen
- Gene:
- SLC12A2 NIH gene
- Name:
- solute carrier family 12 member 2
- Previous symbol:
- -
- Synonyms:
- NKCC1, BSC, BSC2, PPP1R141
- Chromosome:
- 5q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-02-16
- Date modifiied:
- 2016-02-17
Related products to: SLC12A2 antigen
'F 4_80 Antigen (mouse) Host Rat'F 4_80 Antigen (mouse) Host Rat(Anti_Tg)Thyroglobulin Antigen(Des-Asp187)-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse)
(Des-Asp187)-ME20M_ME20S (185-193) (human, bovine, mouse), (Des-Asp187)-Melanocyte Lineage-Specific Antigen GP100 (185-193) (hu(Des-Asp187,Met186)-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse)
(Des-Asp187,Met186)-Melanoma-Associated ME20 Antigen (185-193) (human, bovine, mouse), (Des-Asp187,Met186)-95 kDa Melano(Des_Asp187,Met186)_Melanocyte Protein PMEL 17 (185_193) (human, bovine, mouse) Salt Trifluoroacetate Binding _ Synonym (Des_Asp187,Met186)_Melanoma_Associated ME20 Antigen (185_193) (human, bovine(Des_Asp187,Met186)_Melanocyte Protein PMEL 17 (185_193) (human, bovine, mouse) Salt Trifluoroacetate Binding _ Synonym (Des_Asp187,Met186)_Melanoma_Associated ME20 Antigen (185_193) (human, bovine(Des_Asp187,Met186)_Melanocyte Protein PMEL 17 (185_193) (human, bovine, mouse) Salt Trifluoroacetate Binding _ Synonym (Des_Asp187,Met186)_Melanoma_Associated ME20 Antigen (185_193) (human, bovine(Des_Asp187,Met186)_Melanocyte Protein PMEL 17 (185_193) (human, bovine, mouse) Salt Trifluoroacetate Binding _ Synonym (Des_Asp187,Met186)_Melanoma_Associated ME20 Antigen (185_193) (human, bovine(Draxin) C1ORf187, Antigen blocking peptide(Val438)-Tyrosinase (432-444) (human)
(Val438)-LB24-AB (432-444) (human), (Val438)-Monophenol Monooxygenase (432-444) (human), (Val438)-SK29-AB (432-444) (human), (Val438)-Tumor Rejection Antigen AB (0x19 Antigen0x2 Antigen1,25-dihydroxyvitamin D3 Competitive ELISA, Coated with Antigen105 kDa islet cell antigen,BEM-3,Brain-enriched membrane-associated protein tyrosine phosphatase,ICA105,PTP IA-2,PTPLP,Ptprn,Rat,Rattus norvegicus,Receptor-type tyrosine-protein phosphatase-like N,R-P Related articles to: SLC12A2 antigen
- The WNK3-SPAK-NKCC1 signaling pathway has been implicated in the pathogenesis of brain injury. The aim of this study is to examine the involvement of this pathway in intracerebral hemorrhage (ICH) and evaluate the therapeutic potential of acupuncture in modulating its activity. A total of 210 Sprague Dawley rats were randomly assigned to experimental groups. ICH was induced in all groups except the sham group via autologous blood injection. Point-through-point acupuncture was administered on the Baihui (GV20) and Qubin (GB7) acupoints. Protein expression levels within the WNK3-SPAK-NKCC1 pathway, as well as inflammatory and apoptotic markers in the perihematomal region, were assessed using western blotting, immunohistochemistry, immunofluorescence co-localization, and enzyme-linked immunosorbent assay. Brain water content, hematoxylin-eosin staining, and neurological function scoring were used to evaluate histopathological changes and functional outcomes. Acupuncture significantly improved neurological function, alleviated cerebral edema, and reduced perihematomal pathological injury in ICH rats at all observed time points. Notably, the therapeutic effect was most pronounced after seven consecutive acupuncture treatments. Time-course analysis of WNK3 and cleaved caspase-3 expression, together with correlation analysis, revealed that the neuroprotective effects of acupuncture were potentially associated with WNK3-mediated apoptotic mechanisms. Based on these findings, day 7 was identified as the optimal time point for further mechanistic investigation. At this time point, continuous acupuncture treatment significantly improved neurological function and decreased brain water content. In addition, the expression levels of WNK3, phosphorylated SPAK and NKCC1, TNF-α, and cleaved caspase-3 were significantly reduced, accompanied by decreased NeuN/TUNEL co-localization (p < 0.05), suggesting that acupuncture may exert neuroprotective effects partly through inhibition of the WNK3-SPAK-NKCC1 signaling pathway. Acupuncture may alleviate brain injury following ICH by suppressing activation of the WNK3-SPAK-NKCC1 signaling pathway, thereby decreasing cerebral edema, inflammatory responses, and neuronal apoptosis. - Source: PubMed
Publication date: 2026/05/25
Zhang Bai-WenZheng LeiKuang Bing-LinZheng JiaYu Xue-PingDai Xiao-HongZou Wei - Early postnatal development is a sensitive period for inhibitory maturation, during which GABAergic signaling shifts from depolarizing to hyperpolarizing as a function of the chloride cotransporters KCC2 and NKCC1. Although these cotransporters are key to inhibitory development, little is known about how early caregiving influences their maturation in cortical circuits supporting attachment learning. We characterized KCC2 and NKCC1 expression in the piriform cortex (PC) of male and female rats from postnatal (P) Day 5 to 22 and assessed their sensitivity to altered caregiving using the limited bedding and nesting (LBN) paradigm (P2-P9). Both cotransporters showed robust postnatal protein upregulation, with sex-specific transcriptional differences for KCC2. At P15, LBN induced sex- and region-dependent changes. KCC2 transcription decreased in the anterior PC of males but increased in females in the posterior PC. NKCC1 protein was reduced in both sexes with distinct anterior-posterior patterns. Using a single-neuron Hodgkin-Huxley model with dynamic ion concentrations incorporating the measured cotransporter profiles, simulations indicated that these differences were sufficient to modify chloride homeostasis and shift GABAergic control of excitability. This multiscale approach links early alterations in caregiving to predicted functional consequences for inhibitory maturation in the PC. - Source: PubMed
Becerra-Flores ChristellOruro Enver MMedina-Saldivar CarlosPacheco-Otálora Luis FPardo Grace E - Lymphedema is a chronic condition characterized by the accumulation of fluid due to impaired lymphatic drainage, frequently occurring secondary to chronic venous insufficiency (CVI), malignancy, or obesity. Despite known environmental and clinical risk factors, the genetic contributors to lymphedema and CVI have been understudied. - Source: PubMed
Publication date: 2026/04/22
Peloso Gina MAdhikari NimishYoung Melissa MCho KellyKinlay Scott - Colorectal cancer (CRC) remains a leading cause of cancer‑related morbidity and mortality worldwide. Although the adenoma-carcinoma sequence and its genetic drivers are well described, the earliest cellular and molecular events initiating tumorigenesis within histologically normal colonic epithelium remain poorly defined. This study aims to identify tumor‑initiating cells (TICs), distinguish them from normal stem‑like cells (nSTMs), and delineate early transcriptional and signaling programs using single‑cell RNA sequencing (scRNA‑seq) from paired normal‑appearing and transformed human colonic tissues. - Source: PubMed
Publication date: 2026/03/27
Jaiswal SangeetaThe StephanieChang Tse-ShaoShi JiaqiWang Thomas D - Colorectal cancer (CRC) is the thirdmost common cancer and a leading cause of cancer deaths worldwide, with over 1.9 million cases diagnosed in 2022. Due to poor response to classical cancer treatments, CRC is associated with low survival rates. This creates an urgent need for better understanding of CRC pathology. Cell death occurs continuously in solid tumors, and is also induced acutely, during chemotherapy. Dead cells are cleared by phagocytes via 'efferocytosis', an anti-inflammatory process that can lead to immune escape and reduced therapeutic efficacy. We hypothesized that efferocytosis might contribute to tumor development and that manipulating this process could be beneficial for CRC therapy. - Source: PubMed
Publication date: 2026/03/09
Boeckaerts LauraAaes Tania LøveScheirlinckx EviChoi Sze MenIncik YunusGonçalves AmandaHochepied TinoVereecke LarsRavichandran Kodi S