Peroxin 7 _ PEX7 antigen

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636.35 €

Known as:: Peroxin 7 _ PEX7 antigenic
Catalog number:: 'H00005191-Q01-10
Product Quantity:: 10
Category:: -
Supplier:: ACR
Gene target:: Peroxin 7 _ PEX7 antigen

Related genes to: Peroxin 7 _ PEX7 antigen

Gene:: PEX7 ^{NIH gene}
Name:: peroxisomal biogenesis factor 7
Previous symbol:: -
Synonyms:: PTS2R, RD
Chromosome:: 6q23.3
Locus Type:: gene with protein product
Date approved:: 1997-05-22
Date modifiied:: 2016-10-05

Related products to: Peroxin 7 _ PEX7 antigen

Related articles to: Peroxin 7 _ PEX7 antigen

Determination of the peroxisomal proteome of pathogenic stage .
During infection, exists primarily as an intracellular pathogen of phagocytes, where it overcomes host defense mechanisms and replicates within the phagosome. This intracellular proliferation of yeasts requires the function of the fungal peroxisome for multiple, incompletely defined roles, with early pathogenesis functions dependent on the proper trafficking of peroxisomal matrix proteins carrying a type 1 peroxisome-targeting signal (PTS1). To better understand the potential roles of peroxisomes during infection, we identified the constituents of the peroxisomal proteome of pathogenic-phase yeasts through proximity labeling using a peroxisome-targeted TurboID biotin ligase. Comparative proteomics using peroxisome- or cytosol-localized TurboID identified 90 high-confidence peroxisomal proteins. To validate the peroxisomal proteome, a subset of nine putative peroxisomal proteins was localized to the peroxisome using fluorescent protein fusions. Comparison of peroxisomal proteomes for yeasts lacking the Pex5 or Pex7 cytosolic PTS1 or PTS2 receptors assigned proteins to either the PTS1- or PTS2-dependent peroxisomal import pathways, and refined the Histoplasma PTS1 tripeptide consensus sequence. The peroxisomal proteome of yeast during macrophage infection was ultimately determined to provide relevance to 's primary pathogenic niche. The identities of the proteins comprising the peroxisomal proteome include several enzymes for canonical peroxisome-localized biochemical pathways (e.g., fatty acid utilization and siderophore biosynthesis), but also represent several potential novel functions for the organelle. The defined peroxisomal proteome of pathogenic-phase yeasts, particularly the set of proteins imported via the PTS1 import pathway, thus establishes the important foundation for understanding how peroxisomes promote intracellular pathogenesis. - Source: PubMed
Publication date: 2026/06/09
Brechting Peter JRappleye Chad A
Novel PEX7 gene variant-associated rhizomelic chondrodysplasia punctata type 1: a clinico-radio-biochemical diagnosis.
- Source: PubMed
Publication date: 2026/05/22
A RoshwanthVellingiri BalachandarPeer SameerWander Arvinder
Distinct contributions of the peroxisomal import receptors CgPEX5 and CgPEX7 in regulating fungal growth, conidia development, and pathogenicity of the Colletotrichum gloeosporioides.
Peroxisomes are single-membrane organelles present in most eukaryotic cells and play important roles in various biological activities. PEX5 and PEX7 are peroxisomal receptors that import matrix proteins containing peroxisomal targeting signals into the peroxisome. However, the specific contributions of CgPEX5 and CgPEX7 in the growth, nutritional utilization, conidial development, and pathogenicity of Colletotrichum gloeosporioides remain to be elucidated. Our results demonstrated that deletion of Cgpex5 or Cgpex7 severely inhibited vegetative growth of C. gloeosporioides. However, compared to the ΔCgpex7 strain, the ΔCgpex5 exhibited reduced capacity for carbon and nitrogen sources utilization, lower conidial production, aberrant conidial morphology and downregulated expression of CgBrlA, CgAbaA and CgWetA in C. gloeosporioides. Transcriptome analysis further indicated that Cgpex5 deletion triggered a reprogramming of crucial metabolic pathways, resulting in altered expression of multiple key metabolism-related genes. In addition, the ΔCgpex5 strain exhibited reduced penetration ability, induced smaller lesions on the host, and led to lower levels of host-derived reactive oxygen species (ROS) during infection compared to the ΔCgpex7 strain. Taken together, our results demonstrate that Cgpex5 gene is essential for growth, nutritional utilization, conidial development, and pathogenesis in C. gloeosporioides, whereas Cgpex7 plays a comparatively minor role. These findings indicated that Cgpex5-mediated peroxisomal import pathway represents a promising target for developing novel fungicidal strategies to control postharvest diseases. - Source: PubMed
Publication date: 2026/03/14
Han ZhanhongRen DandanZhu PinkuanGong DiZhang ZhengkePan Yonggui
Metabolomic Profiling Reveals Brain Lipid Alterations in -Deficient Models of Rhizomelic Chondrodysplasia Punctata.
Rhizomelic chondrodysplasia punctata type 1 (RCDP1) is a peroxisomal disorder characterized by skeletal shortening, intellectual disability, seizures, cataracts, and reduced lifespans. RCDP1 is caused by biallelic loss-of-function variants in , which encodes a protein required for importing select enzymes into the peroxisome matrix, including those essential for ether lipid synthesis (e.g., plasmalogens) and the branched-chain fatty acid catabolism. Plasmalogen deficiency is a hallmark of RCDP1 and other peroxisomal disorders, including RCDP types 2-5 (RCDP2-5) and Zellweger spectrum disorders (ZSD). Here, we performed comprehensive metabolomic profiling of clinical samples from RCDP patients and -deficient mouse models. We identified profound neurometabolic disturbances in the cerebral cortex and cerebellum of -deficient mice involving multiple lipid classes, including phosphatidylethanolamines (PEs), phosphatidylcholines (PCs), acylcarnitines, and sphingomyelins. Notably, many of these neurometabolic alterations were absent in patient and -deficient mouse plasma, indicating that plasma-based profiling can underrepresent the extent of CNS lipid remodeling. Overall, these findings reveal novel insights into neurometabolic adaptations to plasmalogen deficiency and suggest the potential involvement of additional pathways that may contribute to neurological dysfunction in RCDP. - Source: PubMed
Publication date: 2025/12/19
Sankhe RiyaWilliams Meredith IFallatah WedadMackay LauraBrown Mary LayneBhagwat PranjaliElsea Sarah HBraverman NancyWangler Michael F
- Source: PubMed

Peroxin 7 _ PEX7 antigen

Related genes to: Peroxin 7 _ PEX7 antigen

Related products to: Peroxin 7 _ PEX7 antigen

Related articles to: Peroxin 7 _ PEX7 antigen

Determination of the peroxisomal proteome of pathogenic stage .

Novel PEX7 gene variant-associated rhizomelic chondrodysplasia punctata type 1: a clinico-radio-biochemical diagnosis.

Distinct contributions of the peroxisomal import receptors CgPEX5 and CgPEX7 in regulating fungal growth, conidia development, and pathogenicity of the Colletotrichum gloeosporioides.

Metabolomic Profiling Reveals Brain Lipid Alterations in -Deficient Models of Rhizomelic Chondrodysplasia Punctata.