Mouse AntiCENPE Target Antigen CENPE Host Isotype Mouse IgG1_ Application ICC; IF; IP; WB (after antigen concentration);
- Known as:
- Mouse AntiCENPE Target Antigen CENPE Host Isotype Mouse IgG1_ Application ICC; IF; IP; Western Blot (after antigenic concentration);
- Catalog number:
- IQ254
- Product Quantity:
- 50ul (0.45mg/ml)
- Category:
- -
- Supplier:
- Imunquest
- Gene target:
- Mouse AntiCENPE Target Antigen CENPE Host Isotype IgG1_ Application ICC; ; (after antigen concentration);
Related genes to: Mouse AntiCENPE Target Antigen CENPE Host Isotype Mouse IgG1_ Application ICC; IF; IP; WB (after antigen concentration);
- Gene:
- CENPE NIH gene
- Name:
- centromere protein E
- Previous symbol:
- -
- Synonyms:
- KIF10, PPP1R61
- Chromosome:
- 4q24
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-04
- Date modifiied:
- 2016-10-05
- Gene:
- PRRT2 NIH gene
- Name:
- proline rich transmembrane protein 2
- Previous symbol:
- ICCA, DYT10
- Synonyms:
- FLJ25513, DKFZp547J199, IFITMD1, FICCA, DSPB3, PKC, EKD1
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-11-25
- Date modifiied:
- 2018-03-19
- Gene:
- SCN5A NIH gene
- Name:
- sodium voltage-gated channel alpha subunit 5
- Previous symbol:
- CMD1E
- Synonyms:
- Nav1.5, LQT3, HB1, HBBD, PFHB1, IVF, HB2, HH1, SSS1, CDCD2, CMPD2, ICCD
- Chromosome:
- 3p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-04-10
- Date modifiied:
- 2019-04-23
Related products to: Mouse AntiCENPE Target Antigen CENPE Host Isotype Mouse IgG1_ Application ICC; IF; IP; WB (after antigen concentration);
Related articles to: Mouse AntiCENPE Target Antigen CENPE Host Isotype Mouse IgG1_ Application ICC; IF; IP; WB (after antigen concentration);
- Accurate segregation of mitotic chromosomes requires pre-anaphase alignment driven by microtubule-based motor proteins. Tubulin detyrosination is essential to guide CENP-E-driven chromosome congression in mitosis. However, the mechanisms of action and physiochemical properties of the detyrosinases for decoding CENP-E motility remain elusive. Here we show that microtubule-associated tyrosine carboxypeptidase (MATCAP) undergoes intrinsically disordered region (IDR)-dependent liquid-liquid phase separation (LLPS) on microtubules to constitute the tubulin detyrosination machinery. These biomolecular condensates selectively enrich tubulin and CENP-E, thereby stabilizing kinetochore-microtubule attachments. Real-time imaging of cells expressing LLPS-deficient MATCAP mutants reveals the importance of MATCAP LLPS dynamics in mitotic chromosome alignment. Mechanistically, phase separation of MATCAP spatiotemporally couples tubulin detyrosination with CENP-E motility to ensure a robust chromosome alignment during mitosis. These findings delineate a signaling cascade that integrates phase separation and tubulin detyrosination with mitotic progression for the maintenance of genomic stability. - Source: PubMed
Publication date: 2026/07/30
Yang TongtongHu WenpingXu PanpanLi HuanyuZhang YaqianXiong FangyuanLi YunzeXu ChaoRuan KeHou ZhonghuaiWang ZhikaiZhang LiangyuYao XuebiaoXiang ShengqiJiang KaiLiu Xing - The prognostic role of molecular subtypes of prostate cancer (PCa) patients is still unclear. And we speculated whether the change of immunologic and hallmark gene sets of adjacent notumor tissues could promote the BCR of PCa patients. - Source: PubMed
Publication date: 2026/07/23
Lin YiweiZhou Jiatong - Oxidative stress and the tumor immune microenvironment jointly shape hepatocellular carcinoma (HCC) progression and response to immunotherapy, yet integrated biomarkers linking these processes are lacking. - Source: PubMed
Publication date: 2026/08/04
Liang YuxinChen XingSu YuhaoZhong DeyuanYan HongtaoChen YahuiWang MingYang QinyanHuang Xiaolun - High-linear energy transfer (LET) radiation such as carbon ions exhibits greater biological effectiveness than conventional low-LET X-rays, but the transcriptional mechanisms underlying this advantage remain incompletely understood. We hypothesized that high-LET radiation induces a qualitatively different transcriptional response rather than simply amplifying low-LET signaling. - Source: PubMed
Publication date: 2026/07/14
Nisar HasanSerçin ÖzdemirhanHellweg Christine E - Chromosomal instability is a common feature of malignancies that arises from persistent defects in chromosome segregation during mitosis. The resulting genetic heterogeneity and acquired malignant traits often characterize advanced disease. However, little is known about the mitotic processes underlying the acquisition of chromosomal instability and whether or how they might contribute to the early stages of cancer initiation. Here, we focused on a characteristic chromosome congression defect termed ECAC (Ectopic Chromosome Around Centrosome), which is observed in human papillomavirus (HPV)-positive cervical dysplasia, a premalignant lesion of the cervix. The expression of the HPV oncoprotein E6 induced proteasome-dependent degradation of the kinetochore motor CENP-E in addition to p53. We then identified the region of CENP-E required for E6-dependent degradation and conducted rescue experiments using a degradation-resistant mutant. These experiments demonstrated that CENP-E degradation is the main cause of the ECAC phenotype. Remarkably, the E6-mediated CENP-E destabilization and the resulting induction of ECAC were observed across multiple high-risk HPV genotypes, indicating that these defects represent a broadly shared pathological feature of oncogenic HPV infection. We also found that sustained E6 expression led to the accumulation of aneuploid cell populations during long-term culture. These findings define the molecular basis of ECAC and suggest that persistent chromosome congression defects can initiate chromosomal instability in premalignant cervical lesions. - Source: PubMed
Publication date: 2026/05/27
Seshimo NanamiHori KanakoFuruta ReikoHirota ToruNozawa Ryu-Suke