IFI35 _ IFP35 antibody Host Mouse
- Known as:
- IFI35 _ IFP35 (anti-) Host Mouse
- Catalog number:
- 'H00003430-B01P
- Product Quantity:
- 50
- Category:
- -
- Supplier:
- ACR
- Gene target:
- IFI35 _ IFP35 antibody Host Mouse
Related genes to: IFI35 _ IFP35 antibody Host Mouse
- Gene:
- IFI35 NIH gene
- Name:
- interferon induced protein 35
- Previous symbol:
- -
- Synonyms:
- IFP35
- Chromosome:
- 17q21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1996-04-12
- Date modifiied:
- 2016-10-05
Related products to: IFI35 _ IFP35 antibody Host Mouse
Related articles to: IFI35 _ IFP35 antibody Host Mouse
- H5N6 highly pathogenic avian influenza virus (HPAIV) poses a serious threat to both poultry and public health due to its ability to cross species barriers. Although interferon-stimulated genes (ISGs) are key components of the host's antiviral defense, a systematic identification and functional characterization of duck ISGs has not yet been conducted. In this study, we identified 815 potential duck ISGs induced by type II interferon (IFN-γ) in duck embryo fibroblasts (DEFs). The majority of these type II ISGs were enriched in immune-related pathways, including "cytokine-cytokine receptor interaction" and "influenza A". Functional validation using siRNA-mediated knockdown demonstrated that six ISGs, including duIFI35, promote H5N6 AIV replication when silenced. Through TUNEL assay, flow cytometry, and apoptotic pathway analysis, Our analysis revealed that H5N6 AIV infection markedly upregulates apoptotic genes such as Fas, FADD, caspase-8, BAK, cytochrome c, APAF1, caspase-9, and caspase-3 (P < 0.05), thereby promoting apoptosis in DEFs. In investigating the antiviral mechanism of duIFI35, it was found that overexpression of duIFI35 further enhanced H5N6-induced apoptosis, as evidenced by increased transcription of these apoptotic genes, whereas duIFI35 knockdown had the opposite effect. Importantly, the antiviral effect of duIFI35 was significantly diminished upon treatment with the caspase inhibitor Z-VAD-FMK (20 μM) (P < 0.05), indicating that its antiviral activity is mediated through apoptosis induction. Collectively, this study provides the first systematic identification of type II ISGs in ducks and reveals duIFI35-mediated apoptosis as a critical antiviral mechanism, offering foundational insights into ISG-driven innate immunity against AIV in waterfowl. - Source: PubMed
Publication date: 2026/04/16
Zhang TaoYang NaMa LuluXu FengxiangLin XiaobingHuang JiangwuGao FeiLiao MingFeng MinDai Manman - Lupus nephritis (LN) represents the most severe renal manifestation of systemic lupus erythematosus (SLE), contributing to significant morbidity. While current assessments focus on glomerular pathology, tubulointerstitial lesions may offer critical insights into disease progression and treatment response. This study develops a clinical prediction model integrating tubulointerstitial molecular signatures. We performed bioinformatics analysis using two independent tubulointerstitial gene expression datasets (GSE113342 and GSE200306), applying batch effect correction and principal component analysis (PCA) to identify differentially expressed genes (DEGs). A protein‒protein interaction (PPI) network isolated hub genes, and least absolute shrinkage and selection operator (LASSO) regression defined the novel "Nscore" parameter predictive of treatment response. The Nscore, incorporating seven key genes (EGR1, IL6R, TFRC, CCL19, IFI16, IFI35, and Fra1), showed a significant positive correlation with 24-h proteinuria and effectively distinguished complete-response (CR)/partial-response (PR) from non-response (NR). Immune deconvolution using the CIBERSORT algorithm revealed an increased abundance of T follicular helper (Tfh) cells and M1 macrophages in NR samples. A clinical nomogram integrating Nscore and sex demonstrated excellent discrimination. This model combines molecular biomarkers with clinical parameters to improve personalized therapeutic stratification, advancing treatment strategies beyond traditional glomerulocentric paradigms and identifying immune cell signatures as potential targets for immunomodulatory interventions. - Source: PubMed
Publication date: 2026/04/02
Ke JialongGu GuanghongNi WenpengHe JialinZeng ZhouyuLin RunpeiPeng JianmingDeng KunyiWen LijuanChen YanhuiTan NanZhang Chilun - Hepatitis B virus (HBV) infection is a major health problem with hundreds of millions of people still chronically infected worldwide. Although it is known that cytokines can inhibit HBV replication in infected hepatocytes, much is still unknown about the underlying mechanisms or mediators. - Source: PubMed
Publication date: 2026/03/30
Kim NayeonShin Jae JinOh Jae WonWon JuheeLee Ah RamDezhbord MehrangizPark JeongwooLee Ki-YoungKim Dong-SikKim Kwang PyoKim Kyun-Hwan - Excessive activation of the immune system by damage-associated molecular patterns (DAMPs) contributes to COVID-19 severity. Interferon-induced protein 35 (IFI35) is a DAMP-related interferon-stimulated gene recently proposed as a biomarker of hyperinflammation. We investigated the association between IFI35 serum levels, gene expression, and COVID-19 severity in 430 hospitalized patients (214 critical and 216 severe) and 112 convalescent controls. Serum IFI35 levels were quantified using ELISA, and IFI35 mRNA expression in PBMCs was assessed using quantitative PCR (qPCR). IFI35 levels were significantly higher in critically ill patients (median 1,003.6 pg/mL) than in severe cases (867.6 pg/mL; = 0.001) and controls (798.3 pg/mL; < 0.0001). Gene expression analysis showed a similar pattern ( = 0.014). Higher IFI35 levels were also associated with adverse clinical outcomes, including mortality, invasive mechanical ventilation, acute kidney injury, and cardiac arrest (all < 0.05). In receiver operating characteristic analysis, adding IFI35 to a model including C-reactive protein and D-dimer improved discriminative performance for mortality. In survival analysis, IFI35 > 1,475 pg/mL was associated with reduced survival in this cohort ( = 0.0062). These findings identify IFI35 as a promising prognostic biomarker associated with COVID-19 severity and adverse outcomes. - Source: PubMed
Publication date: 2026/03/26
Freitas Mariana Ramosde França Chirles AraújoNunes Sávio Luiz PereiraBarbosa Milena Xavierde Souza Carlos Dornels Freireda Costa Armstrong AndersonCarmo Rodrigo Feliciano - Interferon-based local therapy is an intervention for high-risk human papillomavirus (HR-HPV)-associated low-grade squamous intraepithelial lesions (LSIL) or lower-grade cervical abnormalities. This study sought to delineate the differences in clinical outcomes following interferon-based local drug treatment and elucidate the microenvironmental factors driving these disparities. - Source: PubMed
Publication date: 2026/03/10
Ji LingyunWu JingZhou YangPu XiaowenWang XiaoXu BowenJiao RuixianWu WenjuanZhang Wenhong