Mouse Monoclonal to CD324 / E-Cadherin, Clone 67A4, Isotype IgG1Application FC, IP, WB, IHC(F), ICC Concentration
- Known as:
- Mouse Monoclonal CD324 / E-Cadherin, Clone 67A4, Isotype IgG1Application FC, IP, Western Blot, Immunohistochemistry(F), ICC Concentration
- Catalog number:
- 1P-588-T025
- Product Quantity:
- 25 tests
- Category:
- -
- Supplier:
- Exbio
- Gene target:
- Mouse Monoclonal CD324 / E-Cadherin Clone 67A4 Isotype IgG1Application IHC() ICC Concentration
Related genes to: Mouse Monoclonal to CD324 / E-Cadherin, Clone 67A4, Isotype IgG1Application FC, IP, WB, IHC(F), ICC Concentration
- Gene:
- BIRC3 NIH gene
- Name:
- baculoviral IAP repeat containing 3
- Previous symbol:
- API2
- Synonyms:
- cIAP2, hiap-1, MIHC, RNF49, MALT2, c-IAP2
- Chromosome:
- 11q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-10
- Date modifiied:
- 2016-10-05
- Gene:
- CDH1 NIH gene
- Name:
- cadherin 1
- Previous symbol:
- UVO
- Synonyms:
- uvomorulin, CD324
- Chromosome:
- 16q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
- Gene:
- GIHCG NIH gene
- Name:
- GIHCG inhibitor of miR-200b/200a/429 expression
- Previous symbol:
- -
- Synonyms:
- lncRNA-GIHCG
- Chromosome:
- 12q14.1
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2018-07-25
- Date modifiied:
- 2019-01-25
Related products to: Mouse Monoclonal to CD324 / E-Cadherin, Clone 67A4, Isotype IgG1Application FC, IP, WB, IHC(F), ICC Concentration
Related articles to: Mouse Monoclonal to CD324 / E-Cadherin, Clone 67A4, Isotype IgG1Application FC, IP, WB, IHC(F), ICC Concentration
- The most frequent malignancy of the oral cavity is oral squamous cell carcinoma (OSCC), which accounts for up to 80-90% of all malignant neoplasms of the oral cavity. It results from the gradual accumulation of diverse genetic alterations. Alcohol use, tobacco use, betel quid chewing, human papillomavirus (HPV) and poor nutrition are significant risk factors for oral squamous cell carcinoma (OSCC). The cancer suppressor gene E-cadherin establishes a cutoff for Wnt-catenin signaling. Cell-cell adhesion is lost as a result of the Wnt signaling pathway being amplified when E-Cadherin expression is diminished. An antiapoptotic protein called B-cell lymphoma-2 (Bcl-2) interacts with and is controlled by P53. It is a component of the regulatory network that manages the cell cycle and triggers apoptosis. - Source: PubMed
Publication date: 2026/09/30
Shah ZeenatAbbas RezhatDar Mohammad SLatoo Suheel HGowhar Owais - The vertebrate central nervous system is enveloped by the meninges, consisting of the pia, arachnoid and dura layers. The arachnoid is hypothesized to give rise to the most common primary intracranial tumours, meningiomas. However, supporting molecular evidence is lacking. There are no effective medical therapies to treat meningiomas that are resistant to local interventions, encumbered by our limited understanding of their cellular origin. Here, to advance our understanding of meningioma biology, we generated a comprehensive reference single-cell and spatial transcriptomic atlas of human fetal meninges at postconceptional weeks 5-13. We found that the meningeal layers develop concurrently, and identified an inner CDH1-positive dura layer expressing tight-junction genes consistent with barrier function. Comparing meningiomas with fetal meninges, we show that, transcriptionally, meningioma cells resemble dura-lineage cells, and that common meningioma driver genes were expressed in the dura lineage. This raises the hypothesis that meningiomas could originate from dura-lineage cells. - Source: PubMed
Publication date: 2026/09/28
Vinsland ElinMarco Salas SergioKapustová IvanaHu LijuanWebb SimoneLi XiaofeiHe XiaolingNilsson MatsHaniffa MuzlifahBarker Roger APersson OscarRaleigh David RSundström ErikLönnerberg PeterLinnarsson Sten - Early-onset gastric cancer (EOGC), defined as gastric cancer (GC) diagnosed at a young age, has distinct clinicopathological and epidemiological characteristics compared to late-onset GC, suggesting a stronger contribution of genetic susceptibility. However, the specific genes involved and their roles remain uncertain. This systematic review and meta-analysis aimed to evaluate germline risk factors and their association with EOGC. - Source: PubMed
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Sousa FabianaMori GiovanaSilva AnaSilva DanielaSousa-Pinto Bernardo - Interferon-responsive tumor-cell states can simultaneously increase immune visibility and induce immune-regulatory programs, yet their epithelial-cell distribution and treatment responsiveness in bladder cancer remain incompletely defined. We sought to resolve a reproducible epithelial interferon-response state across patients, characterize its immune context, and determine whether its transcriptional components respond to ionizing radiation . - Source: PubMed
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Ji YangZhang YangyangLiu XiaodongLv ZhuoyuanWang YakaiWu ShixuanWang Lei - The continual spermatogenesis throughout adulthood is ensured by a rare and unique cell group named spermatogonial stem cells (SSCs), which undergo self-renewal and/or differentiate into sperm cells. SSCs also become a promising genetic source for the protection of animal biodiversity. However, the isolation and culture of SSCs in vitro is still a big challenge and poorly explored in rabbits. The main objective of this study was to isolate, culture, and deeply characterize SSCs obtained from rabbit testes. Briefly, rabbit testicular tissue was mechanically and enzymatically dissociated, and obtained testicular somatic and germ cells were cultured for a short term in culture media supplemented with specific molecular factors maintaining SSC self-renewal and proliferation (GDNF, GFRα-1, FGF2, etc.). Immunofluorescent and PCR techniques were used for molecular profiling of cultured SSCs, while TEM analysis revealed their ultrastructure. After a few weeks, round and grape-like SSC colonies emerged, growing on the feeder cell layer. Rabbit SSCs showed positive staining for DBA, GFRA1, PLZF, RET, PGP9.5, DAZL, and DDX4. Increased expression of additional SSC markers was noticed using RT-qPCR and dd PCR (RET, PLZF, PGP9.5, DAZL, DDX4, CDH1, CD9, CD14, CD90, c-kit, ALDH, SSEA-4, SALL4, OCT4, and SOX2), while ultrastructure typical for primitive undifferentiated cells was observed under TEM. In conclusion, we successfully established a method for rabbit SSC isolation, culture, and phenotyping, which might facilitate their collection for further cryopreservation. However, the self-renewal, proliferative, and differentiation capacities of cultured SSCs still need to be confirmed through an in vivo SSC transplantation experiment. - Source: PubMed
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