WDR12 (4-269) antibody Host Rabbit
- Known as:
- WDR12 (4-269) (anti-) Host Rabbit
- Catalog number:
- 'GTX120474
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- ACR
- Gene target:
- WDR12 (4-269) antibody Host Rabbit
Related genes to: WDR12 (4-269) antibody Host Rabbit
- Gene:
- LRRC28 NIH gene
- Name:
- leucine rich repeat containing 28
- Previous symbol:
- -
- Synonyms:
- MGC24976, FLJ34269, FLJ45242
- Chromosome:
- 15q26.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-29
- Date modifiied:
- 2014-11-18
- Gene:
- MIR4269 NIH gene
- Name:
- microRNA 4269
- Previous symbol:
- -
- Synonyms:
- hsa-mir-4269
- Chromosome:
- 2q37.3
- Locus Type:
- RNA, micro
- Date approved:
- 2010-04-30
- Date modifiied:
- 2016-11-16
- Gene:
- WDR12 NIH gene
- Name:
- WD repeat domain 12
- Previous symbol:
- -
- Synonyms:
- YTM1, FLJ10881
- Chromosome:
- 2q33.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-07-09
- Date modifiied:
- 2019-02-18
Related products to: WDR12 (4-269) antibody Host Rabbit
Related articles to: WDR12 (4-269) antibody Host Rabbit
- Metabolic reprogramming is a hallmark of gastric cancer (GC); however, the role of transcriptional regulators in modulating glycolysis remains incompletely understood. By integrating proteomic, transcriptomic, and CRISPR-based functional screening datasets, we identified WDR12, a WD40-family protein that is upregulated in GC and associated with poor patient survival. WDR12 silencing suppressed GC cell proliferation and tumor growth in vitro and in vivo and markedly reduced glycolytic flux. Mechanistically, WDR12 interacts with TDP43 and promotes its occupancy at the PFKFB4 promoter, thereby increasing PFKFB4 transcription. Restoration of PFKFB4 expression partially rescued the metabolic and proliferative defects caused by WDR12 knockdown. Together, these findings implicate WDR12 in GC metabolic reprogramming and suggest a potential metabolic vulnerability associated with WDR12-dependent regulation of PFKFB4 through TDP43. - Source: PubMed
Publication date: 2026/09/07
Zhang RutongLiu DehuaFeng XiaoxiCheng AoxingYang ZhenyeZhang Kaiguang - Melanoma is the deadliest skin cancer, and despite the success of immune checkpoint blockade, a substantial fraction of patients fail to respond. Tumors can evade cytotoxic lymphocytes by upregulating multiple inhibitory checkpoints. Here we identify WDR12 as a determinant of immunotherapy resistance: WDR12 expression is elevated in nonresponders, and its genetic inhibition increases intratumoral CD8+ T-cell infiltration and enhances cytotoxic function. Mechanistically, WDR12, in cooperation with the chaperonin subunit CCT7, stabilizes the immune checkpoint CD276 (B7-H3) on tumor cells, thereby suppressing T-cell activity and promoting immune escape. To translate these findings, we identify SU14813 as a small-molecule WDR12 inhibitor that binds WDR12 with high specificity, reduces CD276 stability, and relieves CD276-mediated T-cell suppression. In vivo, WDR12 targeting sensitizes tumors to PD-1 blockade, and combined SU14813 and anti-PD-1 therapy produces superior antitumor efficacy. These results define a WDR12-CCT7-CD276 axis that sustains immune resistance in melanoma and nominate WDR12 inhibition with PD-1 blockade as a promising therapeutic strategy. - Source: PubMed
Publication date: 2026/06/27
Pan JieChang RuiminZhang MengDong QianZhang GuanxiongChen XiangChen MingliangLu LixiaLiang XiaoweiGuo YeyeSu Juan - Osteosarcoma (OS) is a common primary malignant bone tumor in children and adolescents. Increasing evidence suggests that immune dysregulation contributes to OS progression, but its tissue-level and systemic features remain incompletely defined. This study aimed to characterize immune-related alterations in OS and identify key immunoregulatory molecules associated with disease progression. - Source: PubMed
Publication date: 2026/05/07
Zhu JichongHuang ChengqianTan Weiming - Osteosarcoma (OS) stands as the predominant malignant primary bone tumor. WDR12 plays a role in diverse biological processes. Nonetheless, the specific function of WDR12 in OS has not been clearly elucidated. Herein, we found that WDR12 is overexpressed and closely associated with poor prognosis of OS. A diagnostic nomogram based on WDR12 and clinical features of OS could effectively predict the overall survival rate of OS patients. Through functional enrichment analysis, multiple potential pathways related to WDR12 expression in tumorigenesis have been identified. Additionally, the expression level of WDR12 is correlated with the tumor immune microenvironment, immune therapy response, and drug treatment response in OS. Importantly, in vitro experiments demonstrated that downregulation of WDR12 significantly inhibited the proliferation and migration abilities of OS cells and in vivo experiments also confirmed that overexpression of WDR12 could promote tumor growth. Hence, WDR12 has the capacity to emerge as a novel prognostic biomarker and therapeutic target for OS. - Source: PubMed
Publication date: 2026/04/08
Zhang ZhimingChen RuiqiLiu ZhongyueLiu BinfengMei LinYin ChiWan LuLi Zhihong - Cognitive SuperAgers (SAs) are individuals aged 80+ with exceptional episodic memory performance for their age, exceeding middle-aged adult norms. This study integrates family- and association-based methods to identify genetic variants associated with SAs in the Midwestern Amish population. - Source: PubMed
Dorfsman DanielPrough Michael BGulyayev AlexCaywood Laura JClouse Jason EHerington Sharlene DSlifer Susan HAdams Larry DLaux Renee ASong Yeunjoo ELynn AudreyFuzzell Sarada LHochstetler Sherri DMiskimen KristyMain Leighanne RWang PingLiu YiningMoore NoelOgrocki PaulaLerner Alan JVance Jeffery MCuccaro Michael LHaines Jonathan LPericak-Vance Margaret AScott William K