ZNF426 antibody Host Rabbit
- Known as:
- ZNF426 (anti-) Host Rabbit
- Catalog number:
- 'GTX116806
- Product Quantity:
- 0.1 ml
- Category:
- -
- Supplier:
- ACR
- Gene target:
- ZNF426 antibody Host Rabbit
Related genes to: ZNF426 antibody Host Rabbit
- Gene:
- ZNF426 NIH gene
- Name:
- zinc finger protein 426
- Previous symbol:
- -
- Synonyms:
- MGC2663
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-03-25
- Date modifiied:
- 2015-08-26
Related products to: ZNF426 antibody Host Rabbit
Related articles to: ZNF426 antibody Host Rabbit
- The present study aims to identify the differentially expressed genes in HIGK treated with and their possible role in establishing head and neck squamous cell carcinoma. The study design follows a computational approach wherein multiple databases and tools are used to derive the possible association between exposure and the development of HNSCC. The GEOmnibus dataset GSE6927 provided data on the differentially expressed genes in the HIGK treated with . The GEO2R analysis revealed 22 differentially expressed genes in HIGK cells treated with . The expression profile of these genes was then analyzed in the HNSCC (TCGA, Firehose Legacy) dataset employing the UALCAN database. The present study revealed 5 genes , , , , and exhibiting similar expression patterns in -treated HIGK and HNSCC datasets. The and were found to be upregulated, and the genes , , and were downregulated. Among the five genes, the demonstrated a significant association with the survival of HNSCC patients. The low expression of presented a poor prognosis compared to the high expression. The study's results identified as a candidate gene involved in infection and HNSCC. Validating this result is necessary to gain insights into the role of the gene in developing HNSCC. Furthermore, probing the epigenetic factors targeting can be a potential therapeutic lead. - Source: PubMed
Shanmugam S BVijayashree Priyadharsini JAnitha PSmiline Girija A SParamasivam A - Head and neck squamous cell carcinoma (HNSCC) is one of the ten most common cancers. Most cancer cases originate from alcohol and tobacco consumption. However, studies have demonstrated that human papillomavirus () infection, particularly , may also significantly influence disease progression. The KRAB-ZNF family of genes is involved in epigenetic suppression, and its involvement in carcinogenesis is the subject of extensive studies. The available literature data demonstrate that they may play different roles, both as tumor suppressors and oncogenes. In this study, six ZNF genes, , , , , , and , were tested using several in silico approaches based on the TCGA and GEO datasets. Our analyses indicate that the expression of the analyzed ZNFs was significantly downregulated in tumor tissues and depended on tumor localization. The expression levels of ZNFs differed between -positive vs. -negative patients depending on the clinical-pathological parameters. More specifically, the patients with higher levels of and showed better survival rates than those with a lower expression. In addition, the level of expression in -positive () patients was higher than in -negative () patients ( < 0.0001) and was associated with better overall survival (OS). In conclusion, we demonstrate that expression highly correlates with infection, which renders a potential biomarker for HNSCC prognosis and treatment. - Source: PubMed
Publication date: 2022/12/16
Sobocińska JoannaNowakowska JoannaMolenda SaraOlechnowicz AnnaGuglas KacperKozłowska-Masłoń JoannaKazimierczak UrszulaMachnik MartaOleksiewicz UrszulaTeresiak AnnaLamperska KatarzynaKolenda Tomasz - Ovarian cancer is a common gynecological malignant tumor that greatly threatens women's health, so we screened potential biomarkers of ovarian cancer and analyzed their prognostic value. - Source: PubMed
Li HuiqinLi MingTang ChunhuiXu Liang - Microsatellite instability (MSI) has emerged as one of the key biological features of colorectal cancer (CRC). However, controversies remain regarding the association between the MSI status and clinicopathological characteristics of CRC. Therefore, it is crucial to identify potential key genes and pathways associated with MSI in CRC. In the present study, the GSE25071 gene expression profile was retrieved, with thirty‑eight cases of microsatellite stable (MSS), five of MSI‑High (MSI‑H) and three of MSI‑Low (MSI‑L) CRC patients. The differentially expressed genes (DEGs) were analyzed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes pathway enrichment, gene set enrichment analysis (GSEA) and gene co‑expression network analysis. Weighted gene correlation network analysis (WGCNA) was used for the gene modules and correlation of clinical traits. A total of forty‑nine DEGs were identified between MSI‑H and MSS, including six upregulated and forty‑three downregulated DEGs. Only the DEGs of MSI‑H and MSS were subjected to subsequent analysis (limited number of DEGs of MSI‑L and MSS, MSI‑H and MSI‑L). RNA metabolic process, endoplasmic reticulum and chemokine receptor binding were the top ranked terms in GO enrichment. The hub genes of co‑expression network of DEGs included zinc finger protein (ZNF) 813, ZNF426, ZNF611, ZNF320 and ZNF573. The GSEA of MSI‑H and MSS indicated that the mammalian target of rapamycin complex 1 signaling was significantly enriched with a nominal P‑value of 0.038 and normalized enrichment score of 0.446. The WGCNA results showed that the pink module was the top in correlation with MSI status (R2=0.5, P=0.0004). The genes in the pink module were significantly enriched in proteins targeting to endoplasmic reticulum, cytosolic part, structural constituent of ribosome and ribosome pathway. The hub genes identified in the pink module were ribosomal protein L12 (RPL12), RPS3A, RPS9, RPL27A, RPL7, RPL28, RPL14, RPS17, mitochondrial ribosomal protein L16, and G elongation factor, mitochondrial 2. The present study identified key genes and pathways associated with MSI, providing insightful mechanisms. - Source: PubMed
Publication date: 2019/01/11
Yu ChaoranHong HijuZhang SenZong YapingMa JunjunLu AiguoSun JingZheng Minhua - K-RBP is a KRAB-containing zinc finger protein with multiple zinc finger motifs and represses Kaposi's sarcoma-associated herpesvirus (KSHV) transactivator RTA-mediated transactivation of several viral lytic gene promoters, including the ORF57 promoter. Whether K-RBP binds DNA through its zinc fingers and the role of zinc finger domain in repressing gene expression are unclear. Here we report that K-RBP binds DNA through its zinc finger domain and the target DNA sequences contain high GC content. Furthermore, K-RBP binds to KSHV ORF57 promoter, which contains a GC-rich motif. K-RBP suppresses the basal ORF57 promoter activity as well as RTA-mediated activation. The zinc finger domain of K-RBP is sufficient for the suppression of ORF57 promoter activation mediated by the viral transactivator RTA. Finally, we show that K-RBP inhibits RTA binding to ORF57 promoter. These findings suggest that the DNA-binding activity of K-RBP plays an important role in repressing viral promoter activity. - Source: PubMed
Publication date: 2009/07/09
Yang ZhilongWen Hui-JuMinhas VeenuWood Charles