SOX9 antibody Host Rabbit
- Known as:
- SOX9 (anti-) Host Rabbit
- Catalog number:
- 'GTX109661
- Product Quantity:
- 0.1 ml
- Category:
- -
- Supplier:
- ACR
- Gene target:
- SOX9 antibody Host Rabbit
Related genes to: SOX9 antibody Host Rabbit
- Gene:
- SOX9 NIH gene
- Name:
- SRY-box 9
- Previous symbol:
- CMD1, CMPD1
- Synonyms:
- SRA1
- Chromosome:
- 17q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-09-25
- Date modifiied:
- 2018-06-25
Related products to: SOX9 antibody Host Rabbit
Related articles to: SOX9 antibody Host Rabbit
- Osteoarthritis (OA) is a chronic, debilitating degenerative joint disease whose prevalence is rising markedly with the rapid aging of the global population. In this study, we investigated the chondroprotective efficacy of NP-2007, an enzymatically hydrolyzed low-molecular-weight collagen from , using IL-1β-stimulated SW1353 human chondrocyte cells and a medial meniscal transection (MMT)-induced OA rat model. In SW1353 cells, NP-2007 considerably suppressed the expression of inflammatory mediators (iNOS, COX-2) and cytokines (TNF-α, IL-6) without cytotoxicity. Crucially, it restored matrix homeostasis by downregulating catabolic enzymes (MMP-3, MMP-13, and ADAMTS-5) and upregulating anabolic markers (COL2A1, aggrecan), a process associated with the modulation of the Wnt/β-catenin and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathways and the recovery of the master chondrogenic factor SOX9. These in vitro findings were consistent with the in vivo results from the MMT model, where oral administration of NP-2007 (50 and 200 mg/kg) for 8 weeks effectively preserved articular cartilage structure and proteoglycan content while markedly reducing serum levels of catabolic biomarkers, including MMP-13 and COMP. Collectively, our findings demonstrate that NP-2007 exerts potent chondroprotective effects by modulating the balance between cartilage degradation and synthesis, suggesting its potential as a therapeutic candidate for the management of OA. - Source: PubMed
Publication date: 2026/06/26
Kim Min JuLim Hyeon-JiPark In-SunChoi BongsukKim TaeheeCho HyoungKwonKim Seon-YoungJung Chan-Hun - Endometrial organoids, with their three-dimensional structure and robust hormonal responsiveness, have emerged as valuable models for investigating uterine physiology and embryo implantation. However, conventional derivation from endometrial biopsies is invasive, carries surgical risks, and limits repeated sampling. This study introduces uterine lavage fluid as a non-invasive source for generating endometrial organoids. - Source: PubMed
Publication date: 2026/07/14
Qiu HuiyuFan ZhiwenLiu DiDeng LiWang XiaoxiaYang YuanyuanYang TianliTian FenHao JieZhang QiongXu BinFu JingNi HuilingLi YinshuangSu HankunXiao FenSun YuanyuanChen JingjingDuan ZhiyingZhao JingLi HuiLi Yanping - Gastric cancer develops through a sequential carcinogenic process beginning with pyloric metaplasia, a key feature of which is the transdifferentiation of gastric chief cells into spasmolytic polypeptide-expressing metaplastic (SPEM) cells. We found that SOX9, a transcription factor, is highly expressed in SPEM cells in both human and murine metaplasia. We therefore investigated the impact of SOX9-mediated SPEM cell plasticity and function on metaplasia development and progression during gastric carcinogenesis. - Source: PubMed
Publication date: 2026/07/14
Guenther Alexis ARuelas AmandaCaldwell BriannaCho YoungwonZhang ChangqingJang BogunDuncan Benjamin CRomero-Gallo JudithBusada Jonathan TPeek RichardChoi Eunyoung - Chronic inflammation and impaired immune microenvironment are key barriers to effective cartilage regeneration. Herein, we developed an integrated, injectable thermosensitive hydrogel system termed CS@Gel-Mg. This system modularly combines exosome-loaded chitosan microspheres (CM@Exo) embedded within a Mg-coordinated poly(N-isopropylacrylamide)-based ionic liquid hydrogel (Gel-Mg), aiming to modulate local immune response and promote cartilage repair. - Source: PubMed
Publication date: 2026/06/23
Xiong LiChai BinKuang GaixiaKaneko YosukeZhang GonghaoJi Yunhan - Due to the extremely limited intrinsic regenerative ability of cartilage, the repair of articular cartilage defects remains a major clinical challenge at present. Here, through the Schiff-base crosslinking between chitosan and gelatin, reinforced with Sr, an injectable and rapidly gelling composite hydrogel - loaded coaxial electrospun staple fiber was developed. The embedded fibers bridge adjacent pores to form a layered ECM simulation structure, enhancing structural stability, cell adhesion, and local microenvironment regulation. The hydrogel exhibited rapid gelation and obvious shear thinning behavior within 30 s, realizing minimally invasive injection. The encapsulation of Sr within coaxial fibers effectively suppressed initial burst release and achieved sustained ion release for 30 days, with a cumulative release of approximately 60%. In vitro, the composite hydrogel showed good biocompatibility, promoted the proliferation and migration of bone marrow mesenchymal stem cells, enhanced the early cartilage related matrix deposition, and reduced the expression of pro-inflammatory cytokines in LPS stimulated macrophages. In the rat full-thickness cartilage defect model, the sustained release hydrogel showed improved defect filling and hyaline-like cartilage repair at 8 weeks, accompanied by Safranin O staining and significantly increased COL-II and SOX-9 expression. This work may provide an effective strategy for promoting cartilage repair in vivo through the long-term release of biological factors using functional biomass materials. - Source: PubMed
Publication date: 2026/07/13
Zeng JiyangLi WeiDai YuliangLi YaweiMa HongTu ZhimingYuan TaoWang BingDeng Hongbing