GLI1 Western Blot kit other
- Known as:
- GLI1 Western Blot reagent other
- Catalog number:
- 'AWBK32368
- Product Quantity:
- 1 kit
- Category:
- -
- Supplier:
- ACR
- Gene target:
- GLI1 Western Blot kit other
Related genes to: GLI1 Western Blot kit other
- Gene:
- GLI1 NIH gene
- Name:
- GLI family zinc finger 1
- Previous symbol:
- GLI
- Synonyms:
- -
- Chromosome:
- 12q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-01-15
Related products to: GLI1 Western Blot kit other
Human ELC ELISA KIT 96 TEST
OxiSelect In Vitro ROS/RNS Assay Kit (Green Fluorescence), Trial Size
OxiSelect Methylglyoxal (MG) Competitive ELISA Kit
OxiSelect Methylglyoxal (MG) Competitive ELISA Kit
OxiSelect TBARS Assay Kit (MDA Quantitation), Trial Size
OxiSelect Total Antioxidant Capacity (TAC) Assay Kit, Trial Size
OxiSelect™ In Vitro ROS RNS Assay Kit (Green Fluorescence), Trial Size(1-Kit )11,12-EET DHET Immunoassay Kit(1-Kit )11,12-EET_DHET Immunoassay Kit(1-Kit) 11,12-DHET Immunoassay Kit(1-Kit) 14,15-DHET Human Urine ELISA Kit(1-Kit) 14,15-DHET Hypertension ELISA Kit(1-Kit) 14,15-DHET sEH activity ELISA Kit(1-Kit) 14,15-EET DHET Hypertension ELISA Kit(1-Kit) 14,15-EET_DHET Hypertension ELISA Kit Related articles to: GLI1 Western Blot kit other
- Androgenetic alopecia (AGA) involves dihydrotestosterone-driven follicular miniaturization compounded by oxidative stress and perifollicular inflammation, while current pharmacotherapies remain limited by adverse effects. Neem ( A. Juss., Meliaceae) leaves, a phenolic- and limonoid-rich plant widely used in Southeast Asian traditional medicine, were fermented for seven days with a tri-culture consortium of , , and (TRI-NE) to evaluate whether expanded microbial diversity enhances bioactivity relative to the unfermented extract (UN-NE). TRI-NE significantly increased total phenolic content, rising from 315.30 to 564.70 mg GAE/g by day 7, alongside an overall enhancement of antioxidant capacity across all assays. Moreover, untargeted metabolomics revealed compositional remodeling, with 67.47% of significantly altered metabolite features upregulated after fermentation, including selective enrichment of quercetin despite reductions in other polyphenols. In human hair follicle dermal papilla cells (HFDPCs) and complementary models, TRI-NE consistently outperformed UN-NE, enhancing paracrine-mediated fibroblast proliferation, preserving cell viability under potassium-channel blockade, suppressing lipopolysaccharide-induced inflammatory nitric oxide production, and attenuating oxidative membrane damage. At the transcriptional level, TRI-NE downregulated androgen metabolism ( and ) and pro-regression genes () while upregulating Wnt/β-catenin (), Sonic Hedgehog (, , and ), and angiogenic () pathway genes, with effects matching or exceeding standard hair-loss therapeutics. These findings indicate that TRI-NE confers superior bioactivity over the unfermented extract, supporting its potential as a multi-target cosmeceutical candidate for AGA. - Source: PubMed
Publication date: 2026/09/10
Muangsanguan AnurakPanti NiphawanRuksiriwanich WarintornSawangrat KasirawatPummara PattarapaRachtanapun PornchaiSringarm KorawanSommano Sarana RoseKrobthong SucheewinArjin ChaiwatSatsook ApinyaYingchutrakul YodyingCastagnini Juan Manuel - We report the clinical, morphological, ultrastructural, and molecular features of a gastroblastoma diagnosed in a 27-year-old male describing some unreported findings that can help to better understand this very rare tumor. The clinical course lasting 28 years confirms the indolent nature of gastroblastoma, although the disease was metastatic to local lymph nodes and peritoneum at the time of diagnosis. The tumor displayed a predominant monophasic appearance, being composed of epithelial cells with only very rare spindle mesenchymal cells, confirmed at ultrastructural examination. Thorough immunohistochemical investigation demonstrated coexpression of cytokeratins (AE1/AE3, CAM5.2, CK8/18), podoplanin (D2-40), CD56, and NSE in absence of synaptophysin, chromogranin A, DOG1, CD117, CD34, SMA, desmin, vimentin, and S100. In addition, the expression of somatostatin receptor 2 A associated with positive octreoscan and Ga-DOTATOC PET imaging may suggest the use of this nuclear medicine approach for the staging of the tumor and to select patients for possible therapy with somatostatin analogues. The tumor was mismatch repair proteins proficient and did not show any mutation in all 60 genes investigated. Interestingly, targeted RNA sequencing identified a previously unreported TAC3::GLI1 fusion that expands the spectrum of genetic aberrations of gastroblastoma. - Source: PubMed
Publication date: 2026/09/24
La Rosa StefanoBranca FedericaFinzi GiovannaLibera LauraLeutner MonicaSchubart ChristophAgaimy Abbas - Renal fibrosis lacks experimentally tractable human-relevant models that integrate defined stromal programming with spatially controlled profibrotic cues. Here, we developed a dual E-/VE-cadherin-Fc (EVE) interface to condition human mesenchymal stem cells (MSCs) under CTGF/TGF-β stimulation. Cells showed increased expression of Gli-1, NG2, PDGFRβ, and FAP and activated transcription of extracellular matrix remodeling. These changes were consistent with the acquisition of a Gli-1 perivascular-like profibrotic stromal phenotype, and were accompanied by reorganization of cadherin-catenin complexes, actin cytoskeletal rearrangement, and increased YAP nuclear localization. Cell-sized PLGA/chitosan-heparin microparticles were subsequently functionalized with E-/VE-cadherin-Fc and loaded with CTGF/TGF-β. Co-assembly of these microparticles with the conditioned stromal cells (gMSCs) and renal epithelial cells (HK-2) generated 3D renal fibrotic microtissues that combined cadherin-mediated adhesive presentation with localized cytokine delivery. The resulting microtissues exhibited a broader distribution of α-SMA, Collagen I, and Fibronectin, together with reciprocal epithelial-stromal signaling and spatially organized fibrotic activation. As a proof of concept for pharmacological evaluation, the microtissues responded to pirfenidone (PFD) in a dose-dependent manner, with 100 µM PFD reducing α-SMA expression by ∼73% while preserving microtissue viability. Together, these findings establish a material-enabled, cadherin-guided strategy for constructing disease-relevant stromal organization and spatially controlled profibrotic signaling in human renal fibrosis models. - Source: PubMed
Publication date: 2026/09/20
Cheng ZhongQu ZhanyuanSun JiaxinDuan ZhihuaAn YongZhang YanYang Jun - Cerebral ischemia-reperfusion injury (CIRI) triggers endoplasmic reticulum stress (ERS), a key pathological driver of neuronal apoptosis and neurological impairment. While the neuroprotective effects of astragaloside IV (AS-IV) are well-documented, the precise regulatory bridge between the Sonic Hedgehog (SHH) pathway and ERS remains to be elucidated. - Source: PubMed
Publication date: 2026/09/18
Wei PingboHan YangyunWang JunLuo LeMeng JiangFan BoLiu Jiaxin - Arsenic disulfide (AsS) inhibits proliferation and induces apoptosis in diffuse large B-cell lymphoma (DLBCL) cells, its clinical application is constrained by toxicity. Metformin has also been reported to exert antitumor effects across various malignancies. This study investigated whether metformin potentiates the anti-lymphoma efficacy of AsS in DLBCL cells and evaluated associated alterations in apoptosis-related markers and Hedgehog signaling molecules. - Source: PubMed
Publication date: 2026/09/01
Zhang JiahaoLi HuaweiZhao MingxinChen ChenDu ShenghongWang Ling