DHX37 antibody Host rabbit
- Known as:
- DHX37 (anti-) Host host: rabbit
- Catalog number:
- 'ARP36514_P050
- Product Quantity:
- 50
- Category:
- -
- Supplier:
- ACR
- Gene target:
- DHX37 antibody Host rabbit
Related genes to: DHX37 antibody Host rabbit
- Gene:
- DHX37 NIH gene
- Name:
- DEAH-box helicase 37
- Previous symbol:
- DDX37
- Synonyms:
- KIAA1517, MGC4322, MGC2695, Dhr1
- Chromosome:
- 12q24.31
- Locus Type:
- gene with protein product
- Date approved:
- 2001-11-21
- Date modifiied:
- 2017-05-26
Related products to: DHX37 antibody Host rabbit
Related articles to: DHX37 antibody Host rabbit
- Differences in sex development (DSD) with 46,XY karyotype are a group of rare congenital conditions affecting the structure and function of the urogenital system. Published data indicate, that despite the increasingly widespread use of genetic testing, the etiology remains unclear in approximately half of cases. - Source: PubMed
Publication date: 2026/06/27
Błaszczyk EwaWięcek MałgorzataJazela-Stanek AleksandraKudela GrzegorzKoszutski TomaszKowalczyk KarolinaSikora JagodaWiernik AgnieszkaŻarczyńska MałgorzataKempińska WiktoriaBielska-Brodziak AgnieszkaGawlik-Starzyk Aneta - Endogenous double-stranded RNAs (dsRNAs) are immunogenic self-molecules that drive aberrant immune activation under pathological conditions. Here, we show that dsRNAs and their regulation by RNA-binding proteins are key determinants of the fine balance between aging and immunity in Caenorhabditis elegans and cultured human cells. We find elevated levels of dsRNAs with organismal aging and cellular senescence. We identify a moonlighting function for phenylalanyl-tRNA synthetase, FARS-1/FARSA, as a key factor necessary and sufficient for extending lifespan by downregulating dsRNAs, in particular, mitochondrial dsRNAs. FARS-1/FARSA possesses a previously unrecognized dsRNA-binding domain and mediates dsRNA downregulation with the RNA helicase, RHA-2/DHX37, independently of its canonical role in translation. Notably, increased dsRNA expression resulting from genetic inhibition of fars-1/FARSA upregulates immune response-related genes and enhances innate immunity against pathogens. Our study establishes that FARS-1/FARSA is an evolutionarily conserved dsRNA-binding protein that delays aging and promotes longevity by suppressing dsRNA accumulation. - Source: PubMed
Publication date: 2026/05/25
Sohn JooyeonJeon MoonhyeonLee HanseulLim JinAHam SeokjinPark JiSooLee JongsunJung YoonjiLee Gee-YoonMin HyeminKang EunseokJang YerimKong YunheeBong DajeongKim YoosikLee Seung-Jae V - DEAH-box RNA helicase 37 (DHX37) is a highly conserved RNA helicase involved in ribosome biogenesis, RNA metabolism and immune regulation. Dysregulation of RNA helicases has been implicated in tumourigenesis; however, the clinical significance of DHX37 expression in tumours is still emerging and requires further study. This study investigated the expression of DHX37 in large breast and ovarian cancer patient cohorts using immunohistochemistry in 1512 breast and 420 ovarian cancer cases and complementary transcriptomic datasets. In breast cancer, low cytoplasmic DHX37 protein expression was significantly associated with adverse clinicopathological parameters including larger tumour size, higher grade, lymphovascular invasion and positive nodal status (all P < 0.001). Low DHX37 expression was associated with poor breast cancer-specific survival (P < 0.001), particularly among oestrogen receptor-positive patients. In ovarian cancer, low DHX37 expression was associated with lower FIGO stage, absence of residual disease and improved overall survival (P = 0.013). DHX37 shows contrasting prognostic associations in breast and ovarian cancer, suggesting context-dependent biological functions. Reduced DHX37 expression may promote tumour progression in ER-positive breast cancer, but is associated with favourable outcomes in ovarian cancer. These findings highlight DHX37 as a potential prognostic biomarker and underscore the need for functional studies to elucidate its mechanistic role in tumour biology and immune modulation. - Source: PubMed
Publication date: 2026/05/18
Ndeke DenysSam SandraPolchai NuanphanAlshammari KhalidGreener Megan RMarak Tangkam RJoyce JimmyHenman MaisieDeen SuhaGreen Andrew REllis Ian ORakha Emad AMartin Stewart GStorr Sarah J - The clinical phenotype and pathogenic mechanism of 46,XY disorders of sex development (DSD) are complex, and several pathogenic variants are identified by next-generation sequencing. However, these variants currently require additional interpretation and validation prior to their application in 46,XY DSD diagnosis and clinical guidance. - Source: PubMed
Publication date: 2026/04/29
Li CuiYang BinyuLi XuZhen ShuaiLiu XiaogangLi PingpingChen WeiWang XiaoyanXue Mei - INTRODUCTION: This study explores a novel mechanism by which the RNA helicase DHX37 contributes to melanoma and elucidates the reasons for resistance to tumor immunotherapy, providing new insights for the treatment of melanoma. METHOD: This study integrated multiomics data for systematic analysis. The prognostic value of the candidate differentially expressed genes was assessed on the basis of public databases. Single-cell transcriptome data were used to determine the expression patterns of key genes and elucidate intercellular communication networks. Finally, in vitro and in vivo experiments confirmed the mechanism of action of DHX37 in melanoma. RESULTS: Ten key candidate genes that were differentially expressed between primary and metastatic melanoma were identified. Among them, the RNA helicase DHX37 was significantly overexpressed in metastatic tissues, and its high expression was significantly associated with poor overall survival (OS) and shorter progression-free survival (PFS). Functional enrichment analysis revealed that high DHX37 expression was closely related to DNA repair and immune response pathways. Immunological analysis revealed that high DHX37 expression was associated with the formation of an immunosuppressive microenvironment. Single-cell analysis further revealed that DHX37 was specifically expressed primarily in melanoma cells and endothelial cells. In vitro experiments confirmed that knockdown of the DHX37 gene in melanoma cells significantly inhibited tumor cell proliferation and migration. Coculturing DHX37 knockdown melanoma cells with CD8 + T cells significantly increased the secretion of related cytokines. Animal experiments demonstrated that DHX37 knockdown in melanoma cells resulted in smaller tumors and more related immune cytokines. CONCLUSION: This study systematically identified the multiple functions of DHX37 in melanoma progression, suggesting that DHX37 can serve as a potential prognostic biomarker and therapeutic target, providing new insights for precision therapy in melanoma. - Source: PubMed
Publication date: 2026/04/27
Chen RuoxiDong ShiliangZhu XuanruChu XiaodongLiu Hongwei