DHX37 antibody Host rabbit
- Known as:
- DHX37 (anti-) Host host: rabbit
- Catalog number:
- 'ARP36514_P050
- Product Quantity:
- 50
- Category:
- -
- Supplier:
- ACR
- Gene target:
- DHX37 antibody Host rabbit
Related genes to: DHX37 antibody Host rabbit
- Gene:
- DHX37 NIH gene
- Name:
- DEAH-box helicase 37
- Previous symbol:
- DDX37
- Synonyms:
- KIAA1517, MGC4322, MGC2695, Dhr1
- Chromosome:
- 12q24.31
- Locus Type:
- gene with protein product
- Date approved:
- 2001-11-21
- Date modifiied:
- 2017-05-26
Related products to: DHX37 antibody Host rabbit
Related articles to: DHX37 antibody Host rabbit
- To investigate the clinical characteristics, inheritance patterns, and genotype-phenotype correlations of DHX37 variants in 46,XY disorders of sex development (DSD). - Source: PubMed
Publication date: 2026/07/21
Xu XiaochaWu XiaochengChen ShuaiMiao HaixiaFang KexinWu DingwenZhang YiYang Xin - Differences in sex development (DSD) with 46,XY karyotype are a group of rare congenital conditions affecting the structure and function of the urogenital system. Published data indicate, that despite the increasingly widespread use of genetic testing, the etiology remains unclear in approximately half of cases. - Source: PubMed
Publication date: 2026/06/27
Błaszczyk EwaWięcek MałgorzataJazela-Stanek AleksandraKudela GrzegorzKoszutski TomaszKowalczyk KarolinaSikora JagodaWiernik AgnieszkaŻarczyńska MałgorzataKempińska WiktoriaBielska-Brodziak AgnieszkaGawlik-Starzyk Aneta - Endogenous double-stranded RNAs (dsRNAs) are immunogenic self-molecules that drive aberrant immune activation under pathological conditions. Here, we show that dsRNAs and their regulation by RNA-binding proteins are key determinants of the fine balance between aging and immunity in Caenorhabditis elegans and cultured human cells. We find elevated levels of dsRNAs with organismal aging and cellular senescence. We identify a moonlighting function for phenylalanyl-tRNA synthetase, FARS-1/FARSA, as a key factor necessary and sufficient for extending lifespan by downregulating dsRNAs, in particular, mitochondrial dsRNAs. FARS-1/FARSA possesses a previously unrecognized dsRNA-binding domain and mediates dsRNA downregulation with the RNA helicase, RHA-2/DHX37, independently of its canonical role in translation. Notably, increased dsRNA expression resulting from genetic inhibition of fars-1/FARSA upregulates immune response-related genes and enhances innate immunity against pathogens. Our study establishes that FARS-1/FARSA is an evolutionarily conserved dsRNA-binding protein that delays aging and promotes longevity by suppressing dsRNA accumulation. - Source: PubMed
Publication date: 2026/05/25
Sohn JooyeonJeon MoonhyeonLee HanseulLim JinAHam SeokjinPark JiSooLee JongsunJung YoonjiLee Gee-YoonMin HyeminKang EunseokJang YerimKong YunheeBong DajeongKim YoosikLee Seung-Jae V - DEAH-box RNA helicase 37 (DHX37) is a highly conserved RNA helicase involved in ribosome biogenesis, RNA metabolism and immune regulation. Dysregulation of RNA helicases has been implicated in tumourigenesis; however, the clinical significance of DHX37 expression in tumours is still emerging and requires further study. This study investigated the expression of DHX37 in large breast and ovarian cancer patient cohorts using immunohistochemistry in 1512 breast and 420 ovarian cancer cases and complementary transcriptomic datasets. In breast cancer, low cytoplasmic DHX37 protein expression was significantly associated with adverse clinicopathological parameters including larger tumour size, higher grade, lymphovascular invasion and positive nodal status (all P < 0.001). Low DHX37 expression was associated with poor breast cancer-specific survival (P < 0.001), particularly among oestrogen receptor-positive patients. In ovarian cancer, low DHX37 expression was associated with lower FIGO stage, absence of residual disease and improved overall survival (P = 0.013). DHX37 shows contrasting prognostic associations in breast and ovarian cancer, suggesting context-dependent biological functions. Reduced DHX37 expression may promote tumour progression in ER-positive breast cancer, but is associated with favourable outcomes in ovarian cancer. These findings highlight DHX37 as a potential prognostic biomarker and underscore the need for functional studies to elucidate its mechanistic role in tumour biology and immune modulation. - Source: PubMed
Publication date: 2026/05/18
Ndeke DenysSam SandraPolchai NuanphanAlshammari KhalidGreener Megan RMarak Tangkam RJoyce JimmyHenman MaisieDeen SuhaGreen Andrew REllis Ian ORakha Emad AMartin Stewart GStorr Sarah J - The clinical phenotype and pathogenic mechanism of 46,XY disorders of sex development (DSD) are complex, and several pathogenic variants are identified by next-generation sequencing. However, these variants currently require additional interpretation and validation prior to their application in 46,XY DSD diagnosis and clinical guidance. - Source: PubMed
Publication date: 2026/04/29
Li CuiYang BinyuLi XuZhen ShuaiLiu XiaogangLi PingpingChen WeiWang XiaoyanXue Mei