PDGFB Reverse PCR Primer (500bp position)
- Known as:
- PDGFB Reverse PCR test kit Primer (500bp position)
- Catalog number:
- MP1164
- Product Quantity:
- ea
- Category:
- -
- Supplier:
- Panomics
- Gene target:
- PDGFB Reverse PCR Primer (500bp position)
Related genes to: PDGFB Reverse PCR Primer (500bp position)
- Gene:
- PDGFB NIH gene
- Name:
- platelet derived growth factor subunit B
- Previous symbol:
- SIS
- Synonyms:
- SSV
- Chromosome:
- 22q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-01-14
Related products to: PDGFB Reverse PCR Primer (500bp position)
Related articles to: PDGFB Reverse PCR Primer (500bp position)
- Giant cell-rich tumors of soft tissue present a significant diagnostic challenge due to pronounced morphological overlap, particularly in limited tissue samples. This review provides a streamlined update on the clinicopathological and molecular features of nine distinct entities: nodular fasciitis, juvenile xanthogranuloma, phosphaturic mesenchymal tumor, tenosynovial giant cell tumor, giant cell fibroblastoma, giant cell-rich solitary fibrous tumor, giant cell tumor of soft tissue, keratin-positive giant cell-rich tumor, and undifferentiated pleomorphic sarcoma. While these neoplasms are unified by a prominence of multinucleated giant cells, recent genomic insights have identified signature, diagnostically defining molecular drivers. We highlight characteristic gene fusions, including USP6, NTRK1, FN1, CSF1, COL1A1-PDGFB, NAB2-STAT6, and HMGA2-NCOR2, as well as entities characterized by non-recurrent or highly complex genomic alterations. Synthesizing these data, this review underscores the critical role of advanced molecular testing in resolving diagnostic ambiguities, refining tumor classification, and guiding targeted therapeutic strategies. - Source: PubMed
Nishio JunAoki Mikiko - Vascular instability, characterized by impaired pericyte coverage, is a hallmark of tumor progression. ATP6L is highly expressed in colorectal cancer (CRC) tissues and promotes tumor progression by enhancing the tumor microvasculature; however, its direct impact on vascular stability remains unclear. ATP6L expression, microvascular morphology, and pericyte coverage were analyzed by immunohistochemistry in a cohort of 179 CRC specimens, and the role of ATP6L in vascular stability was further investigated by modulating its expression both in vitro and in vivo. In vitro, MC38 and CT26 cells with ATP6L overexpression or knockdown were co-cultured with mouse vascular smooth muscle cells (MOVAS), and MOVAS proliferation, migration, and apoptosis were evaluated using EdU incorporation, transwell migration, and TUNEL staining assays, respectively. PDGFB secretion and PDGFRβ expression were assessed by ELISA, Western blotting, and immunofluorescence. Along the normal colorectal mucosa-adenoma-adenocarcinoma sequence, ATP6L upregulation was closely associated with progressive vascular instability, characterized by loss of pericyte coverage and increasing vascular morphological heterogeneity. Mechanistically, ATP6L overexpression promoted extracellular acidification, suppressed PDGFB secretion, and subsequently reduced PDGFRβ expression in pericytes, thereby impairing their recruitment and survival. Conversely, ATP6L knockdown attenuated extracellular acidification, restored PDGFB/PDGFRβ signaling, and rescued pericyte proliferation, migration, and survival. These findings identify ATP6L as a key mediator of perivascular dysfunction in CRC and demonstrate that ATP6L-induced extracellular acidification disrupts vascular stability by suppressing the PDGFB/PDGFRβ signaling axis and impairing pericyte function. - Source: PubMed
Publication date: 2026/08/28
Tian XiangdongChen DandanDuo JiaqiZhang ShiQi Lisha - Inflammatory rhabdomyoblastic tumors (IRMT) are newly described entities characterized by a near-haploid karyotype. Most IRMTs exhibit indolent behavior; however, rare malignant transformation has been reported. We report a case of IRMT with malignant progression. - Source: PubMed
Publication date: 2026/08/29
Shiraishi KengoMakise NaohiroKojima RyutaTakahashi TsukasaOdaka AkikoOikawa MarikoAmano YusukeAraki AkinobuFukuda SawatoMita YukiyoshiFukumoto IchiroKinoshita TakashiKawazu MasahitoHanazawa Toyoyuki - Severe nitrogen (N) deficiency inhibits crop growth and yield, while low use efficiency of N fertilizer causes resource waste and environmental harm. Enhancing crop N use efficiency (NUE) is thus a critical scientific challenge. Ecofriendly and cost-effective silicon (Si) fertilizer can enhance NUE across the entire soil-plant continuum. Si-mediated improvements in soil physicochemical properties and microbial community structure underlie enhanced mineralization and suppressed denitrification. Si-cell wall interactions support symbiont recognition, nodule initiation, and formation of functional nodules for sustained N fixation. Si also upregulates genes encoding N transporters and assimilatory enzymes to improve N uptake, assimilation, and remobilization. This mini-review synthesizes Si's roles in regulating soil N transformation and plant N uptake, assimilation, and remobilization. It aims to support precision Si fertilization strategies that reduce synthetic N input without compromising yield. - Source: PubMed
Publication date: 2026/08/13
Li ZinaWang TianyuJimu JianliLiu YuanLi WenbingSheng Huachun - Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing soft tissue sarcoma arising from dermal fibroblasts. Breast involvement is extremely rare, posing diagnostic and therapeutic challenges. We retrospectively reviewed eight cases of breast DFSP managed at our center over a 10-year period. The cohort included seven females and one male with a median age of 39.1 years. Clinical presentations were diverse: one patient had multiple areolar nodules, five presented with breast lumps including three with recurrent lumps, which is an uncommon presentation for DFSP, one had an ulceroproliferative growth with bleeding, and one presented following excision of a recurrent lump elsewhere with histopathology showing positive margins. Histological diagnosis was confirmed via core biopsy or block review. Four patients had classic DFSP, while three had fibrosarcomatous transformation. All cases of DFSP showed CD34 positivity. Wide local excision was performed in seven patients, and one underwent mastectomy. Two patients received adjuvant radiotherapy. No recurrence was observed within six months. Breast DFSP is rare and requires histopathological confirmation. Core biopsy with appropriate histologic features and CD34 immunostaining aids in diagnosis. Wide local excision remains the primary treatment approach. Radiotherapy is recommended in cases with close or positive margins, recurrence, metastatic disease, or when surgery is not feasible. Targeted therapy with Imatinib Mesylate, a tyrosine kinase inhibitor, is reserved for unresectable or metastatic lesions, provided the COL1A1::PDGFB translocation involving chromosomes 17 and 22 [t (17; 22)] is confirmed. Long term stringent follow up is required as recurrence in breast has been noted 26 years following primary treatment in literature. - Source: PubMed
Publication date: 2026/01/07
Surendra ShreyaSahu ShaliniRaj SanthoshDaniel NirmalSen SupriyaSam Thomas ShawnAbera MeskeremBalakrishnan RajeshCherian Anish JacobPaul Mazhunvanchary Jacob