IRF7 Forward PCR Primer (450bp position)
- Known as:
- IRF7 Forward PCR test kit Primer (450bp position)
- Catalog number:
- MP1153
- Product Quantity:
- ea
- Category:
- -
- Supplier:
- Panomics
- Gene target:
- IRF7 Forward PCR Primer (450bp position)
Related genes to: IRF7 Forward PCR Primer (450bp position)
- Gene:
- IRF7 NIH gene
- Name:
- interferon regulatory factor 7
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11p15.5
- Locus Type:
- gene with protein product
- Date approved:
- 1996-11-13
- Date modifiied:
- 2019-04-23
Related products to: IRF7 Forward PCR Primer (450bp position)
Related articles to: IRF7 Forward PCR Primer (450bp position)
- Fibrocytes represent a distinct somatic cell type derived from peripheral blood leukocytes, first described as spindle-shaped adherent cells with dual hematopoietic and mesenchymal features. Although fibrocytes were identified in early descriptive studies across several mammalian systems, most of this work predated modern molecular approaches, and the cells remain incompletely defined at the molecular level and have not previously been derived or characterized in cattle. Seeking somatic cells that could be collected aseptically and reproducibly under field conditions for reprogramming to pluripotency, we recognized fibrocytes as a practical and previously unexplored candidate population. Here, we establish a reproducible method for fibrocyte derivation and expansion from adult bovine blood and define their molecular identity using transcriptomic and network analyses. Principal component and differential expression analyses revealed extensive immune, inflammatory, metabolic, and stress-responsive pathways that distinguished fibrocytes from fibroblasts. Upstream regulator analysis identified a fibrocyte-restricted transcriptional network governed by SPI1, IRF5/IRF7, NFKBIZ, PRDM1, CIITA, and MAFB, supporting a monocyte-derived origin and indicating some retention of hematopoietic lineage memory despite acquisition of mesenchymal features. Optimized fibrocyte medium (FbC; dexamethasone, ascorbate, PDGF-BB, EGF, A83-01, CHIR99021) supported stable proliferation and selectively enhanced cytoskeletal and matrix-constructive programs while attenuating inflammatory tone. As proof-of-principle, fibrocytes reprogrammed with polycistronic OCT4-SOX2-KLF4-cMYC and SV40 large T antigen, fibrocytes generated induced pluripotent stem cell (iPSC) colonies exhibiting defining molecular and morphological features of pluripotency. These findings establish fibrocytes as a field-adaptable, stably expandable, and reprogrammable somatic cell type with practical applications in induced pluripotent stem cell generation, genetic preservation, and reproductive biotechnology. - Source: PubMed
Publication date: 2026/09/14
Sylvester HannahKoganti Prasanthi PGurung ShaileshPillai Viju VSelvaraj Vimal - - Source: PubMed
Publication date: 2026/09/11
Kong MingZhu ChenghaoXue YujiaHong WenxuanZhang GuoqingJiang DingshengXu YongGuo Junli - Genome-wide association studies have identified genetic polymorphisms at 11p15 associated with systemic lupus erythematosus (lupus). Statistical fine mapping prioritizes a highly prevalent coding haplotype within IRF7. Analysis of ancient DNA confirms that this haplotype has persisted at high frequencies in the global population for millennia. The IRF7 risk haplotype is sufficient to increase nuclear localization of IRF7 and transcriptional activity downstream of pattern recognition receptor pathways. This risk haplotype increases IRF7 DNA-binding strength and alters IRF7 DNA sequence specificity, resulting in genotype-dependent increases in interferon-α production in numerous biological systems, including monocytes and airway epithelial cells. CRISPR engineering of the corresponding risk variant in mouse Irf7 results in both enhanced innate control of virus infection and increased autoantibody titers in a model of autoimmunity. Altogether, we establish a persistent and prominent IRF7 haplotype that amplifies IRF7 activity in a manner that has immunological risks and benefits. - Source: PubMed
Publication date: 2026/09/11
Virolainen Samuel JCreighton KathrynDashtiahangar MaryamKrishnamurthy DurgaParks LoisForney CarmyAmpadu BritneyRudrapatna Akshata NDunn Katelyn AParameswaran SreejaHesse Hayley KChen XiaotingVonHandorf AndrewEdsall Lee EYin CailingLynch ArthurGittens OliviaDiouf Arame AJones Sydney HHass MatthewJavier EllenDonmez OmerKeddari YasineDanzinger OdedSeelamneni HarshaNamjou-Khales BahramAinsworth Hannah CComeau Mary EMarion Miranda CGlenn Stuart BNath Swapan KFreedman Barry ITsao Betty PKamen Diane LBrown Elizabeth EGilkeson Gary SAlarcón Graciela SReveille John DJames Judith ACriswell Lindsey AVilá Luis MAlarcón-Riquelme Marta EPetri MichelleScofield R HalKimberly Robert PRamsey-Goldman RosalindBae Sang-CheolGraham Deborah CunninghameVyse Timothy JGuthridge Joel MGaffney Patrick MLangefeld Carl DKelly Jennifer AKaufman Kenneth MSivils Kathy LHarley John BShen NanLawson Lucinda PBaglaenko YuriyMiraldi Emily RRosenberg Brad RSiggers TrevorWaggoner Stephen NWeirauch Matthew TKottyan Leah C - Compared with chickens and ducks, pigeons exhibit higher resistance to RNA virus infection. Interferon regulatory factor 7 (IRF7) was identified a member of the interferon regulatory factors (IRFs) family, which plays an important role in innate immune response. Subsequent studies have shown that IRF7 performs a diverse function in multiple biological processes. In this study, pigeon IRF7 (piIRF7) was first cloned, and bioinformatics analysis showed that IRF7 varies among species, but the IRF and IRF3 domains are highly conserved. Further study showed that only NDV infection upregulated IRF7 mRNA levels in vivo, and NDV, AIV, FPV infection, and nucleic acids mimic stimulation also significantly upregulated piIRF7 mRNA levels in PEFs. Furthermore, overexpressing piIRF7 promoted IFNs and IFN-stimulated genes (ISGs) activation and inhibited NDV and VSV replication. Importantly, we observed that pigeon and chicken IRF7 suppressed viral replication more efficiently than human and bat IRF7 in IRF7 DF-1 cells. Structurally, we discovered that the IRF domain of piIRF7 is indispensable for IFN-β activation. This study provides data to identify the function of piIRF7 and to better understand antiviral innate immunity in pigeons. - Source: PubMed
Publication date: 2026/07/27
Shao QiLiu QiujuWang JieLi ShuhanWang ZhaofeiMa JingjiaoWang HenganYan YaxianCheng YuqiangSun Jianhe - Hope has been associated with improved quality of life and lower mortality in cancer, but the underlying biological mechanisms are poorly characterized. We previously reported that hope was associated with less inflammation and more normalized diurnal cortisol pre-treatment among women with ovarian cancer. We also reported associations of socio-environmental factors with pro-metastatic processes. Here, we used genome-wide transcriptional profiling to quantify associations between hope and tumor molecular signatures reflecting invasiveness, inflammation, and cellular immunity. - Source: PubMed
Publication date: 2026/09/08
Lutgendorf Susan KCorn Benjamin WThaker Premal HGoodheart Michael JPenedo Frank JSood Anil KCole Steven W