HOXA2 Gene Promoter Reporter Vector
- Known as:
- HOXA2 Gene Promoter Reporter Vector
- Catalog number:
- LR1030
- Product Quantity:
- 10 ug
- Category:
- -
- Supplier:
- Panomics
- Gene target:
- HOXA2 Gene Promoter Reporter Vector
Related genes to: HOXA2 Gene Promoter Reporter Vector
- Gene:
- FOXD3 NIH gene
- Name:
- forkhead box D3
- Previous symbol:
- -
- Synonyms:
- Genesis, HFH2
- Chromosome:
- 1p31.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-22
- Date modifiied:
- 2015-08-25
- Gene:
- HOXA2 NIH gene
- Name:
- homeobox A2
- Previous symbol:
- HOX1K
- Synonyms:
- -
- Chromosome:
- 7p15.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-02-18
- Date modifiied:
- 2015-08-25
Related products to: HOXA2 Gene Promoter Reporter Vector
Mouse Nanog Stem Cell Differentiation Reporter (pGreenZeo, plasmid)α - Calcitonin Gene Related Peptide, α - CGRP, rat-14 gene protein,Alpha-globin regulatory element-containing gene protein,C16orf35,CGTHBA,Homo sapiens,Human,MARE,Nitrogen permease regulator 3-like protein,NPRL3,Protein CGTHBA10.3 kDa proline-rich protein DAMS,DAMS,Homo sapiens,Human,SMAD5 antisense gene protein 1,SMAD5 antisense RNA 1,SMAD5 opposite strand protein,SMAD5-AS1,SMAD5OS14-3-3 β_α Polyclonal Antibody, Reactivity: H M R, Gene ID: 7529, Synonyms: YWHAB14-3-3 β_α Polyclonal Antibody, Reactivity: H M R, Gene ID: 7529, Synonyms: YWHAB14-3-3 ε Polyclonal Antibody, Reactivity: H M R , Gene ID: 7531, Synonyms: YWHAE14-3-3 ε Polyclonal Antibody, Reactivity: H M R , Gene ID: 7531, Synonyms: YWHAE14-3-3 ζ_δ Polyclonal Antibody, Reactivity: H M R , Gene ID: 7534, Synonyms: YWHAZ14-3-3 ζ_δ Polyclonal Antibody, Reactivity: H M R , Gene ID: 7534, Synonyms: YWHAZ14-3-3 τ Polyclonal Antibody, Reactivity: H M R, Gene ID: 10971, Synonyms: YWHAQ14-3-3 τ Polyclonal Antibody, Reactivity: H M R, Gene ID: 10971, Synonyms: YWHAQ14_3_3_sigma (SFN) Gene Promoter Reporter Vector15-oxoprostaglandin 13-reductase,D3T-inducible gene 1 protein,Dig1,DIG-1,Dithiolethione-inducible gene 1 protein,Ltb4dh,NADP-dependent leukotriene B4 12-hydroxydehydrogenase,PRG-1,Prostaglandin reduct160 kDa nucleoporin,Gene trap locus 1-13 protein,Gtl1-13,GTL-13,Kiaa0197,Mouse,Mus musculus,Nuclear pore complex protein Nup160,Nucleoporin Nup160,Nup160 Related articles to: HOXA2 Gene Promoter Reporter Vector
- Neural crest progenitor cells are the main contributors to craniofacial cartilage and connective tissue of the vertebrate head. These progenitor cells also give rise to the pigment, neuronal and glial cell lineages. To study the molecular basis of neural crest differentiation, we have cloned the gene disrupted in the mont blanc (mob(m610)) mutation, which affects all neural crest derivatives. Using a positional candidate cloning approach we identified an A to G transition within the 3' splice site of the sixth intron of the tfap2a gene that abolishes the last exon encoding the crucial protein dimerization and DNA-binding domains. Neural crest induction and specification are not hindered in mob(m610) mutant embryos, as revealed by normal expression of early neural crest specific genes such as snail2, foxd3 and sox10. In addition, the initial stages of cranial neural crest migration appear undisturbed, while at a later phase the craniofacial primordia in pharyngeal arches two to seven fail to express their typical set of genes (sox9a, wnt5a, dlx2, hoxa2/b2). In mob(m610) mutant embryos, the cell number of neuronal and glial derivatives of neural crest is greatly reduced, suggesting that tfap2a is required for their normal development. By tracing the fate of neural crest progenitors in live mont blanc (mob(m610)) embryos, we found that at 24 hpf neural crest cells migrate normally in the first pharyngeal arch while the preotic and postotic neural crest cells begin migration but fail to descend to the pharyngeal region of the head. TUNEL assay and Acridine Orange staining revealed that in the absence of tfap2a a subset of neural crest cells are unable to undergo terminal differentiation and die by apoptosis. Furthermore, surviving neural crest cells in tfap2a/mob(m610) mutant embryos proliferate normally and later differentiate to individual derivatives. Our results indicate that tfap2a is essential to turn on the normal developmental program in arches 2-7 and in trunk neural crest. Thus, tfap2a does not appear to be involved in early specification and cell proliferation of neural crest, but it is a key regulator of an early differentiation phase and is required for cell survival in neural crest derived cell lineages. - Source: PubMed
Publication date: 2004/02/25
Barrallo-Gimeno AlejandroHolzschuh JochenDriever WolfgangKnapik Ela W