STAT6 TAD in vivo Kinase Assay Kit
- Known as:
- STAT6 TAD vivo Kinase Assay Kit
- Catalog number:
- LK0023
- Product Quantity:
- 10ug
- Category:
- Peptides
- Supplier:
- Panomics
- Gene target:
- STAT6 TAD vivo Kinase Assay Kit
Related genes to: STAT6 TAD in vivo Kinase Assay Kit
- Gene:
- STAT6 NIH gene
- Name:
- signal transducer and activator of transcription 6
- Previous symbol:
- -
- Synonyms:
- D12S1644, IL-4-STAT
- Chromosome:
- 12q13
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-09
- Date modifiied:
- 2019-04-23
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- Extra-uterine endometrial stromal sarcoma (EESS) is a rare mesenchymal tumour, and primary gastric involvement represents an exceptionally unusual presentation. Because such tumours present as ulcerated submucosal masses, they are easily misdiagnosed as gastrointestinal stromal tumours (GIST), making accurate, timely recognition critical for appropriate management. A 53-year-old woman presented with a five-day history of epigastric pain, low-grade fever, and malaise. Computed tomography (CT) imaging revealed an 11 cm vascular mass on the greater curvature of the stomach with splenic-hilum and transverse-colon contact, without evidence of local invasion. Upper gastrointestinal endoscopy revealed a friable ulcerated lesion, and biopsies suggested a spindle-cell neoplasm favouring GIST. At laparotomy, the tumour was found to infiltrate the stomach, splenic hilum, colon serosa, and omentum. An en bloc partial gastrectomy, splenectomy, segmental colectomy, cholecystectomy, and omentectomy were performed; final pathology showed microscopic involvement of the gastric radial soft-tissue margin. Histology demonstrated a primary gastric low-grade ESS with a vascular pattern and low mitotic index, while immunohistochemistry showed diffuse CD10/ER/PR positivity and absence of c-KIT, DOG-1, desmin, S100, SOX10, and STAT6, excluding GIST, leiomyosarcoma, PEComa, solitary fibrous tumour, and schwannoma. Targeted RNA-based sequencing identified a canonical JAZF1::SUZ12 fusion, confirming low-grade EESS. Given the tumour's low-grade, hormone-receptor-positive biology and microscopic radial margin involvement, adjuvant endocrine therapy with letrozole (2.5 mg daily) was initiated. At the six-month follow-up, the patient remained asymptomatic with no radiological evidence of recurrence. Primary gastric ESSS remains an exceptional finding and is easily mistaken for GIST. Accurate diagnosis and optimal management depend on comprehensive histology and immunohistochemistry, supported by fusion-gene testing, to guide individualised surgical and adjuvant management. Given the tumour's potential for very late relapse, prolonged surveillance is warranted despite the favourable short-term outcome. - Source: PubMed
Publication date: 2026/03/23
Mylonakis AdamKyros EleandrosKarakeke MariaKarakeke EleniPanagakis AndreasKastanaki PagonaKarydakis LysandrosPergaris AlexandrosSakellariou StratigoulaPapalampros Alexandros - Solitary fibrous tumors (SFTs) were initially perceived as benign, pleural-based neoplasms but have since been recognized for their potential for local recurrence and distant metastasis, occurring across various anatomical sites. This manuscript delves into the clinicopathological characteristics, treatment outcomes, and follow-up data of patients with SFTs treated at our institution. - Source: PubMed
Publication date: 2026/03/14
Raja AnandMakineni HemantBary AshikKrishnamurthy Shalini ShreeSundersingh ShirleyDutt VivaanKrishnan Chandra Kumar - Allergic airway inflammation, a hallmark of asthma, is commonly driven by environmental allergens such as house dust mite (HDM). This study examined the protective effects of caraway (Carum carvi) and marjoram (Origanum majorana) extracts in a rat model of HDM-induced allergic airway inflammation. Daily HDM intranasal administration was applied over four weeks, with or without concurrent oral administration of the herbal extracts. Both treatments significantly reduced airway inflammation, total serum IgE, and pro-inflammatory cytokines (IL-6 and TNF-α), as well as the regulatory cytokine IL-10 in bronchoalveolar lavage fluid (BALF). RT-qPCR revealed a marked downregulation of Th2-associated cytokines (IL-4, IL-5, and IL-13) and the mucus-related gene Muc5ac, along with the restoration of the regulatory marker Foxp3. Consistently, ELISA analysis of BALF showed partial recovery of the Th1 cytokine IFN-γ. Western blotting confirmed reduced protein expression of NF-κB and STAT6 in treated groups. Histological examination showed notable improvement in lung architecture. Collectively, these findings suggest that caraway and marjoram attenuate HDM-induced airway inflammation through immunomodulatory and anti-inflammatory mechanisms, supporting their potential as complementary therapeutic agents for allergic asthma. - Source: PubMed
Publication date: 2026/04/20
Refaat Ahmed MMohammed Honyda SAli FaroukMohamed HebaAbdallah RaniaAbdel-Salam Bahaa K A - Synovial sarcoma is an aggressive and rare malignant soft tissue neoplasm, typically affecting young adults and predominantly arising near major joints. Primary cranial involvement is extremely uncommon. In rare circumstances, patients may develop multiple soft tissue tumors either synchronously or metachronously, raising a challenging differential diagnosis between metastatic disease and a second primary malignancy. We report the case of a woman diagnosed with a primary high-grade cranial synovial sarcoma, treated with wide surgical resection followed by adjuvant radiotherapy, who remained disease-free for two years. She later presented with multifocal skeletal lesions. Biopsies taken from two distinct bone lesions demonstrated diffuse STAT6 positivity and the absence of SS18 rearrangement by molecular analysis. These features, confirmed by independent pathological reviews and a multidisciplinary tumor board, were consistent with a multifocal solitary fibrous tumor rather than metastatic disease. This rare case highlights the diagnostic complexity of multifocal skeletal lesions developing after primary cranial synovial sarcoma and emphasizes the importance of thorough pathological, molecular, and multidisciplinary evaluation. - Source: PubMed
Publication date: 2026/04/20
Yazar CÖzkul EYazar KSönmez F T - Inhaled fungal pathogens often generate granuloma-contained latent infections that can reactivate to cause invasive disease. However, why protective pathways fail to achieve sterilizing immunity in this setting is unclear. Here, we identify type 2 inflammation as a major arm of immunosuppression during latent, granulomatous fungal infection. Using reporter mice, we found that TH2 cells were the dominant source of type 2 cytokines and deletion of IL-4/IL-13, Stat6, or TH2 cells drove fungal clearance. Type 2 signaling acted on monocyte-derived myeloid cells that formed an ARG1+ ring around the granuloma core. STAT6 was required cell intrinsically in this compartment, and its loss reduced lung burden. Contrary to an intracellular-niche model, we found that Cryptococcus was predominantly extracellular in vivo. STAT6 deficiency did not enhance macrophage intracellular killing, but instead antagonized IFNγ-dependent protection against extracellular yeast. These findings identify a spatially organized TH2-STAT6 checkpoint that limits IFNγ-mediated extracellular killing and maintains cryptococcal latency. - Source: PubMed
Publication date: 2026/04/20
Zheng YufanJean Pierre MakheniAnsaldo EduardDobson Hannah EKamenyeva OlenaOnyishi Chinaemerem UDouglas SarahFebres Aldana ChristopherEngin Zerk PinarSereti IriniBetancourt Jovany JNielsen KirstenMcCaffery ErinDang Eric V