EGR1 ELISA Kit
- Known as:
- EGR1 Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- EK1700
- Product Quantity:
- Kit
- Category:
- Peptides
- Supplier:
- Panomics
- Gene target:
- EGR1 ELISA Kit
Related genes to: EGR1 ELISA Kit
- Gene:
- EGR1 NIH gene
- Name:
- early growth response 1
- Previous symbol:
- -
- Synonyms:
- TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225
- Chromosome:
- 5q31.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-11
- Date modifiied:
- 2016-10-05
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- Glucagon-like peptide-1 receptor agonists (GLP-1RAs) hold clinical promise in promoting wound healing. This study investigated the pro-healing effect and potential molecular mechanism of polyethylene glycol loxenatide (PEG-Lox). - Source: PubMed
Zhao ZhiyiYue HanXu WeijieGong SongShao Shiying - Histone deacetylases (HDACs) regulate neuroprotection; however, Trichostatin A (TSA), an HDAC inhibitor, lacks clear molecular mechanisms and core targets in Alzheimer's disease (AD), limiting clinical translation. This study aimed to decipher TSA's AD-regulating network, screen core genes, and support AD early diagnosis and multi-target therapies. - Source: PubMed
Publication date: 2026/04/20
Ou ChangzeChen BinbinDeng JunLong Huajun - The early growth response 1 () gene is a well-known immediate-early gene in the family. It encodes cysteine-2-histidine-2 (C2H2)-type zinc-finger DNA binding domain. EGR1 is involved in various developmental processes, including cell proliferation, differentiation, inflammation, neuroplasticity, angiogenesis, and endocrine. deficiency causes infertility due to impaired ovulation associated with the non-expression of LHβ. It has also been suggested that EGR1 may be essential for endometrial differentiation. Interestingly, EGR1 suppresses or activates the expression of downstream genes, depending on the cellular environment and stimuli. This is suspected to be influenced by the level of EGR1, its structure, and its interactions with other transcription regulators. gene is constructed with 2 exons and 1 intron without alternative spliced transcripts in both human and mouse. expression is under the control of itself and other - and -factors. has one promoter and a few enhancers with differences between human and mouse. The promoter contains binding sites for various transcription factors, including EGR1, activator protein 1 (AP1), EGR1 binding site (EBS), and specificity protein 1 (SP1). TATA and CAT boxes are present in the mouse Egr1 gene, but the TATA box is found only in humans. EGR1 is also suggested as a target for treatment for some diseases, like cancer, but it requires much more basic knowledge. Understanding EGR1's cell type-specific functions at the various levels will be helpful in understanding the normal development and in finding therapeutic targets in reproduction, cancer, and immune-related diseases. In this review, we briefly summarize the genetic anatomy with the molecular and developmental roles of EGR1. - Source: PubMed
Publication date: 2026/03/31
Na In-HaCheon Yong-Pil - The treatment of oral submucosal fibrosis (OSF) is challenging owing to the complex pathogenesis. It is characterized by excessive collagen deposition in the subepithelium along with epithelial damage. Betel nut chewing is considered a major cause of OSF. We previously found that phosphodiesterase 12 (PDE12) was involved in the oral mucosal epithelial barrier damage, promoting the occurrence of OSF. Early growth response 1 (EGR1), a well-characterized transcription factor, has been implicated in the development of fibrotic diseases, including oral fibrosis. This study aimed to explore the effects and underlying mechanisms of PDE12 overexpression on oral epithelial cells in OSF. Overexpression of PDE12 was employed to verify its critical role in mitochondrial dysfunction and oral mucosal epithelial barrier disruption in HOKs. Subsequently, electrophoretic mobility shift assay and chromatin immunoprecipitation analysis were performed to demonstrate that EGR1 interacted with the promoter of the PDE12 gene, thereby upregulating its expression in HOKs. By combining EGR1 silencing and PDE12 overexpressing strategies, our study confirmed that PDE12-induced impairment of mitochondrial function and oral mucosal epithelial barrier was dependent on EGR1. These findings suggest that regulating the expression of PDE12 through EGR1 could alleviate arecoline-induced epithelial injury, thereby inhibiting the development of OSF and offering a potential therapeutic strategy to combat OSF. - Source: PubMed
Publication date: 2026/04/16
Peng JingChen LinlinXie JinmeiWang XiWang XuerouChen CailianWang RongXie Xi - Gulf War Illness (GWI) is a chronic neuroimmune condition affecting veterans of the 1990-91 Gulf War. Current treatments primarily target symptom relief, and the biological mechanisms underlying GWI remain poorly understood. Using a validated mouse model of Gulf War Illness (GWI) combining corticosterone (CORT) and diisopropyl fluorophosphate (DFP) exposure to induce stress- and toxicant-related neuroimmune priming, we examined how prior exposure alters molecular responses to a subsequent immune challenge. Male mice were exposed to CORT and DFP with repeated intermittent CORT, followed by lipopolysaccharide (LPS) or saline to assess transcriptional and epigenetic changes in brain and blood. We analysed transcript abundance, chromatin accessibility, and DNA methylation in the hippocampus, frontal cortex, and blood at 6 h, 12 h and 24hrs after LPS challenge (3-4 mice per group). We identified widespread transcriptional changes and dynamic chromatin accessibility following LPS exposure, with DNA methylation modifications that persisted in the hippocampus and blood. Thirty-three genes, including , , , and , were differentially expressed and methylated in both hippocampus and blood across all time points. These genes clustered in immune- and glial-related pathways. Transcription factor analysis revealed enrichment of NF-κB, CREB1, EGR1, JUN, and MYC binding motifs in regions with differential methylation. Our findings identify novel candidate biomarkers in peripheral blood that reflect brain molecular changes, providing a new framework for elucidating the long-term epigenetic impacts of stress and toxicant exposure in GWI. - Source: PubMed
Publication date: 2026/03/11
Sasaki AKelly K AMichalovicz L TAshbrook D GWijenayake SO'Callaghan J PMcGowan P O