PBGD binding protein EMSA Kit
- Known as:
- PBGD binding protein EMSA Kit
- Catalog number:
- AY1379
- Product Quantity:
- 25 rxn
- Category:
- -
- Supplier:
- Panomics
- Gene target:
- PBGD binding protein EMSA Kit
Related genes to: PBGD binding protein EMSA Kit
- Gene:
- HMBS NIH gene
- Name:
- hydroxymethylbilane synthase
- Previous symbol:
- PBGD, UPS, PORC
- Synonyms:
- -
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: PBGD binding protein EMSA Kit
Related articles to: PBGD binding protein EMSA Kit
- Feline mesenchymal stem cells (MSCs) isolated from adipose (A-MSCs) and uterine (U-MSCs) tissues during routine ovariohysterectomy represent valuable therapeutic sources in veterinary regenerative medicine. While quantitative real-time PCR (qRT-PCR) remains the gold standard for transcriptional profiling in these cells, its analytical reliability relies on empirically validated reference genes. In this study, we assessed the expression stability of nine candidate reference genes (, , , , , , , , and ) in feline A-MSCs and U-MSCs using the geNorm and NormFinder algorithms. Both computational approaches identified and as the most stably expressed genes across both cell types, whereas the historically popular was the least stable. All geNorm pairwise variation values were below the commonly used threshold of 0.15 in both A-MSCs and U-MSCs. To illustrate the impact of reference gene choice, we evaluated the pluripotency marker . Normalizing using and revealed significant differences in expression between A-MSCs and U-MSCs ( < 0.05). In contrast, applying the unstable masked this difference. These findings identify and as promising reference gene candidates for qRT-PCR normalization in P3 undifferentiated feline A-MSCs and U-MSCs. - Source: PubMed
Publication date: 2026/09/02
Miah RubelLee Sang-YunSong Su HyeonPark Dong-JuChoe Yong-HoLee Sung-LimLee Won-JaeJo Chan-HeeBok Eun-YeongLee Hyeon-JeongJin Yong-XunJeong Yeon-WooSon Young-Bum - Evidence guiding antimicrobial dosing during interruptions and liberation from continuous renal replacement therapy (CRRT) is lacking. We aimed to optimize meropenem and piperacillin dosing during 6-h and 24-h interruptions. - Source: PubMed
Publication date: 2026/09/24
Zhang LinnaColmenero ManuelLiu XinRoberts Jason AUlldemolins Marta - Acute intermittent porphyria (AIP) is a rare autosomal dominant metabolic disorder caused by hydroxymethylbilane synthase (HMBS) deficiency, resulting in the accumulation of neurotoxic porphyrin precursors. Its rarity and overlap with psychiatric, neurological, and gastrointestinal clinical features frequently lead to diagnostic delays and substantial morbidity. Therefore, we report the case of a 19-year-old woman who presented to a UK tertiary hospital with recurrent tonic-clonic seizures and severe episodes of abdominal pain over a four-year period. After initial investigations excluded cardiac and epileptic causes, she was diagnosed with pseudoseizures and referred to a psychiatric facility because no conclusive epileptiform activity was detected on electroencephalography (EEG). Multiple gastrointestinal diagnostic investigations, including gastric emptying studies, were unsuccessful in identifying an underlying cause. Following postoperative deterioration characterized by nausea, vomiting, and seizures, porphyria screening was initiated. Fecal total porphyrins were elevated at 72.3 nmol/g (reference range, 0-49.9 nmol/g), raising strong biochemical suspicion of an acute hepatic porphyria and prompting specialist referral, while plasma and urinary porphyrin levels remained within normal limits. The patient was referred to a specialist porphyria clinic for genetic confirmation and management. This case illustrates the diagnostic complexity of AIP, in which overlapping neurological and psychiatric features can frequently result in misdiagnosis, and demonstrates that fecal porphyrin elevation can provide valuable complementary biochemical evidence when other investigations are inconclusive, particularly when testing is performed outside an acute episode. AIP should therefore be considered in young women with recurrent unexplained seizures and abdominal pain, especially when standard investigations, including urinary aminolevulinic acid (ALA) and porphobilinogen (PBG), are unremarkable, as normal urinary ALA and PBG levels measured outside an acute attack do not exclude AIP. Early metabolic screening, including fecal porphyrin analysis, may prevent years of morbidity and facilitate timely specialist referral. - Source: PubMed
Publication date: 2026/08/20
Rezwan DilshadDhinakharan S R - Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. - Source: PubMed
Publication date: 2026/08/04
Ulldemolins MartaLipman JeffreyLiu XinAbdul-Aziz Mohd-HafizBaptista João PBilgrami IrmaBitker LaurentBoidin ClementBrinkmann AlexanderCheng VesaChoi GordonCole C LouiseDe Waele Jan JDeans RenaeEastwood Glenn MEscobar LeslieFrey Otto RGarreau RomainGoutelle SylvainGresham RebeccaHernandez-Mitre Maria PatriciaJamal Janattul AinJoynt Gavin MKanji SalmaanKielstein Jan TKluge StefanKönig ChristinaKoulouras Vasilios PLassig-Smith MelissaLaterre Pierre-FrancoisLee AnnaLefrant Jean-YvesLei KatieLeung PatriciaMat-Nor Mohd-BasriMudaliar YuganOstermann MarliesPaul Sanjoy KPeake Sandra LRello JordiRichard Jean-ChristopheRichards BrentRoberts Darren MRoberts Michael SRoehr Anka CRoger ClaireSeoane LeonardoShekar KiranSinnollareddy MahipalSousa EduardoSpring AnnaStarr ThereseStephens DianneTaccone Fabio SilvioThomas JaneTurnidge JohnValkonen MiiaWallis Steven CWilliams TriciaWittebole XavierWright Daniel F BZikou Xanthi TRoberts Jason A - Porphyrias are rare inherited disorders of heme synthesis caused by reduced activity of one of the eight enzymes in the pathway. When early precursors accumulate, acute hepatic porphyrias occur, which present as severe neurovisceral attacks. When later, light-sensitive porphyrins accumulate, they cause cutaneous forms with chronic photosensitivity, blistering and skin fragility. Although these patterns are usually distinct, acute, and cutaneous features may appear together. This may reflect two separate genetic defects, but more often occurs when oxidative stress, such as from iron overload, chronic infection, or drugs, secondarily inhibits the fifth enzyme, uroporphyrinogen decarboxylase. This creates a mixed porphyrin pattern in which the usual distinctions between acute and cutaneous porphyrias are blurred, making diagnosis challenging. - Source: PubMed
Publication date: 2026/07/07
Masemola Kagiso MMasemola Kgaogelo RDintshi MogomotsiPillay Taryn