EGR2 BP EMSA Kit
- Known as:
- EGR2 BP EMSA Kit
- Catalog number:
- AY1304
- Product Quantity:
- 25 rxn
- Category:
- -
- Supplier:
- Panomics
- Gene target:
- EGR2 EMSA Kit
Related genes to: EGR2 BP EMSA Kit
- Gene:
- EGR2 NIH gene
- Name:
- early growth response 2
- Previous symbol:
- KROX20
- Synonyms:
- -
- Chromosome:
- 10q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-31
- Date modifiied:
- 2019-04-23
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- Peripheral nerve transection requires surgical treatment, although functional recovery remains incomplete. Here, we developed a biofunctional nanocomposite nerve interface combining an ion-covalent gelatin methacryloyl (GelMA)/Laponite hydrogel with engineered thermostable fibroblast growth factor-2 (FGF-2) to recreate a regenerative microenvironment. Laponite incorporation (2%-2.5% w/v) precisely modulated the hydrogel network, providing shear-thinning behavior, enhanced viscoelasticity, microporosity, a twofold increase in compressive modulus, controlled degradation, injectability, and three-dimensional (3D) bioprintability. Functionalization with thermostable FGF-2 enabled sustained release while preserving bioactivity, promoting Schwann cell viability, metabolic activity, cytoskeletal organization, and upregulation of nerve growth factor receptor (NGFR), glial cell line-derived neurotrophic factor (GDNF), early growth response protein 2 (EGR2), octamer-binding transcription factor 6 (OCT6), and SRY-box transcription factor 9 (SOX9). Nerve interfaces consisting of a basal polycaprolactone (PCL) layer and a biofunctional GelMA (10%)/Laponite (2%) hydrogel containing FGF-2 (1 µg mL ) were fabricated by 3D bioprinting followed by visible-light crosslinking. In a rat neurotmesis model, FGF-2-functionalized wraps significantly improved motor function, electrophysiological recovery, Schwann cell activity (S100 calcium-binding protein), neurofilament organization and myelination (FluoroMyelin), and muscle preservation. Collectively, this work introduces a 3D-bioprinted, cell-instructive nerve interface integrating mechanical neuroprotection with sustained neurotrophic signaling to enhance peripheral nerve regeneration. - Source: PubMed
Publication date: 2026/09/04
Rodriguez-Sanchez Diego NJoshi AkshatSafari Saeedde Carvalho Leticia A MMuller Kevin SKim UijinCartarozzi Luciana PKamaraj MeenakshiErmis Meneksede Barros Natan Rde Oliveira Alexandre L R - Endometrial injury, often resulting from iatrogenic procedures or infections, can lead to fibrosis, adhesions, and infertility. Current therapies are inadequate for reversing fibrosis or restoring normal function. Mesenchymal stem cell-derived exosomes (MSC-exos) present therapeutic potential; however, their rapid clearance poses a challenge. The purpose of this study was to develop a thermosensitive Pluronic F-127 (PF-127) hydrogel for sustained intrauterine delivery of human umbilical cord MSC-derived exosomes (PF-127-hUCMSC-exos) and to evaluate its efficacy and underlying mechanisms in a rat model of ethanol-induced endometrial injury. - Source: PubMed
Bao LiweiLi LiTang ShengbinTang YeziWang ZihanTan JiaxiZhang HuihuiLiu RushiZhang Xia - Nasopharyngeal carcinoma (NPC) is a multifactorial disease driven by both genetic and environmental factors. The neurogenic locus notch homolog 1 (NOTCH1) gene has dual oncogenic and tumor-suppressive effects that depend on the cellular context. An intronic single nucleotide polymorphism (SNP) in NOTCH1, rs3124599, has been linked to various diseases. However, its involvement in NPC remains unknown. This study aims to explore the regulatory and susceptibility effects of rs3124599 on NPC. - Source: PubMed
Publication date: 2026/08/31
Sultan Mujeeb ARomdhoni Achmad ChusnuWungu Citrawati Dyah KenconoPurwono Priyo Budi - Repeated morphine administration for managing persistent pain frequently induces both physical and psychological dependence, accompanied by alterations in cortical gene expression. To elucidate the molecular underpinnings of morphine dependence, gene expression in the frontal cortex of mice subjected to acute and chronic morphine treatment was profiled using microarray analysis and validated by semi-quantitative PCR. Genes including and were upregulated following both acute and chronic morphine treatment. Gene ontology analysis revealed significant enrichment of differentially expressed genes in membrane components, GPCR signaling pathways, and neurological system processes, indicating integrated alterations in receptor-mediated signaling and downstream transcriptional regulation. Consistent with this, selective phosphorylation of CREB was observed during naloxone-precipitated withdrawal, highlighting CREB-dependent transcription as a key molecular correlate of cortical neuroadaptation. Behavioral assays confirmed robust physical and psychological dependence, supporting the functional relevance of these molecular changes. Collectively, these findings identify a GPCR-centered molecular framework in which coordinated regulation and functional interaction of receptors such as DRD2 and ADORA2A, along with associated signaling components, contribute to morphine-induced neuroplasticity and dependence. These insights may provide a foundation for the development of targeted therapeutic strategies to mitigate opioid dependence. - Source: PubMed
Publication date: 2026/08/31
Kim MijinMoon SohyeonYayeh TaddesseVilla TheaOh Seikwan - Cocaine use disorder is marked by strong interindividual variability, yet the molecular determinants underlying vulnerability in females remain poorly characterized. Here, we adapted a statistical model previously validated in males to classify female rats exposed to a cocaine-induced conditioned place preference paradigm into two subgroups: those expressing cocaine reward (CPP expression (CPPE), score >74 s) and those showing no preference ((nCPPE), score between -19 and 53 s), independently of estrous-cycle influences. Despite identical cocaine exposure, two clear behavioral phenotypes emerged, with no differences in baseline emotional-like, cognitive, or hedonic-like measures. Whole-transcriptome sequencing of the nucleus accumbens during CPP expression and following reinstatement revealed extensive transcriptional differences between subgroups. CPPE females showed strong upregulation of immediate early genes (Egr1, Egr2, Egr4) and enrichment of pathways implicated in addiction-related neuroplasticity, including MAPK, cAMP signalling, axon guidance, and glutamatergic transmission. Reinstatement further differentiated CPPE and nCPPE rats, notably through persistent IEG activation and modulation of circadian regulators such as Rorb and Per2, suggesting a potential involvement of circadian-related mechanisms signature in cocaine vulnerability. Additional novel candidates, including SLC transporters and genes involved in synaptic organization, were identified in resilient females. Together, these findings provide an integrated behavioral and transcriptomic characterization of cocaine-induced interindividual variability in female rats and highlight molecular mechanisms that may contribute to vulnerability and resilience to cocaine's rewarding effects. - Source: PubMed
Publication date: 2026/08/31
Gasparri JoséphineCuris EmmanuelEskenazi ClaraBourdon CelineCourtin CindieMegarbane BrunoMarie-Claire CynthiaBenturquia Nadia