CYP1A1 EMSA Kit
- Known as:
- CYP1A1 EMSA Kit
- Catalog number:
- AY1290
- Product Quantity:
- 25 rxn
- Category:
- -
- Supplier:
- Panomics
- Gene target:
- CYP1A1 EMSA Kit
Related genes to: CYP1A1 EMSA Kit
- Gene:
- CYP1A1 NIH gene
- Name:
- cytochrome P450 family 1 subfamily A member 1
- Previous symbol:
- CYP1
- Synonyms:
- P450DX, P1-450, P450-C, CP11
- Chromosome:
- 15q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
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- Benzo[a]pyrene (B[a]P) is a carcinogenic food contaminant formed during thermal processing. Citrus depressa peel, a processing byproduct rich in polymethoxyflavones (PMFs) including nobiletin (NOB), was evaluated for detoxification-related effects in rats. C. depressa peel ethanol extract (CDHPE) was characterized, and its effects on xenobiotic metabolism and B[a]P disposition were assessed. NOB showed measurable oral bioavailability and multi-tissue distribution. Dietary CDHPE or NOB for 7 days increased hepatic phase I/II enzyme activities and intestinal CYP1A1 activity, accompanied by increased hepatic nuclear Nrf2 and reduced ROS levels. Pre-feeding reduced plasma B[a]P AUC by 57-79% and tissue burden by 30-80%, with increased urinary excretion of parent B[a]P. Upregulation of selected Nrf2 downstream target proteins (GCLC, HO-1, NQO1) and significant GCLC mRNA induction are consistent with Nrf2-associated detoxification responses, although causal confirmation by loss-of-function approaches remains needed. These findings support the potential use of citrus peel byproducts as functional ingredients for dietary PAH mitigation. - Source: PubMed
Publication date: 2026/09/04
Li Mei-LingChiang Yu-HsuanHuang Shang-MingYao Hsien-TsungHsu Kuo-Chiang - Fragrance products are widely used in daily life. Nevertheless, the biological effects associated with specific fragrance formulations remain insufficiently characterized due to the complexity of their chemical composition. This study aimed to provide an integrated multi-organ evaluation of the effects of inhaling a tested commercial fragrance formulation on oxidative stress, physiological parameters, neurotoxicity-related biomarkers, and gene expression in rats, and to assess the potential protective role of vitamin E. - Source: PubMed
Publication date: 2026/08/26
Al-Sowayan Noora SalehAl-Shebel Daniyah Khaled - Per- and poly- fluoroalkyl substances (PFAS) are ubiquitous, persistent toxicants. In the environment, PFAS co-occur with other compounds, including agonists of the aryl hydrocarbon receptor (AHR). In this study, in silico molecular docking, in vitro enzyme activity, and the in vivo zebrafish model were used to identify PFAS that may interact with the AHR pathway and assess impacts for developmental toxicity. Of the PFAS and proteins modeled, perfluorooctane sulfonate (PFOS) was predicted in silico by AutoDock Vina to have good affinity for CYP1A1 . This prediction was supported by enzyme inhibition assays in vitro, where PFOS inhibited human CYP1A1 (estimated IC50 of 35 μM). For in vivo testing, two PFAS were selected: PFOS and the related perfluorohexane sulfonate (PFHxS), which did not inhibit CYP1A1 activity at tested concentrations in vitro. Zebrafish embryos were exposed from 24 to 100 hours post-fertilization to mixtures of PFAS (16 μM) with and without the AHR agonist β-naphthoflavone (βNF; 3.67, 36.7, and 183.6 nM). Co-exposures of βNF and PFOS caused severe morphological deformities not observed with either compound alone, accompanied by reduced Cyp1a-like enzyme activity, and cyp1a gene expression. In contrast, PFHxS did not interfere with Cyp1a activity in vivo and did not cause developmental toxicity. This suggests developmental toxicity of mixtures containing PFOS may be underestimated, and identification of other PFAS that interact with the AHR pathway is warranted. - Source: PubMed
Publication date: 2026/09/09
Miller Davis HLachapelle AdamSatbhai Kruuttika MChien PeterBorys Kristina ATimme-Laragy Alicia R - Enterotoxigenic (ETEC) is a major cause of infectious diarrhea, characterized by excessive inflammatory responses and intestinal barrier disruption. Spermidine (SPD), a naturally occurring polyamine, has been implicated in intestinal homeostasis; however, its protective effects and underlying mechanisms against ETEC-induced intestinal injury remain unclear. - Source: PubMed
Publication date: 2026/08/25
Jiang PengLing ZhaoHan ShuoWang Jing - Cytochrome P450 1B1 (CYP1B1) is selectively overexpressed in various tumor cells and plays a critical role in the metabolic inactivation of chemotherapeutic agents, leading to drug resistance. Therefore, the development of selective CYP1B1 inhibitors represents a promising strategy to overcome chemoresistance. In this study, we designed and synthesized 19 novel trans-stilbene derivatives by introducing fluorine atoms or fluorinated side chains, aiming to potentially enhance drug metabolic stability and binding affinity. Among them, compounds 4h and 4i exhibited the most potent inhibitory activity against CYP1B1, with ICvalues of 6.5 ± 0.9 nM and 5.4 ± 0.5 nM, respectively, and demonstrated high selectivity within the CYP1 family over CYP1A1 and CYP1A2. In A549 cell models, both compounds significantly reversed DMBA-induced PTX resistance in a concentration-dependent manner. Furthermore, fluorescence staining revealed that compound 4i preferentially bound to CYP1B1-overexpressing tumor cells, including A549, HeLa, MCF-7, and HCT-15 cells, but not to non-cancerous 293T cells. These findings highlight the potential of fluorinated trans-stilbene derivatives as promising CYP1B1-targeted therapeutics for combating drug-resistant cancers. - Source: PubMed
Publication date: 2026/09/02
Yang MeixianLiu XinWei XinQiu DachuanChen WeijuanCai Jiajing