CP1B EMSA Kit
- Known as:
- CP1B EMSA Kit
- Catalog number:
- AY1285
- Product Quantity:
- 25 rxn
- Category:
- -
- Supplier:
- Panomics
- Gene target:
- CP1B EMSA Kit
Related genes to: CP1B EMSA Kit
- Gene:
- CYP1B1 NIH gene
- Name:
- cytochrome P450 family 1 subfamily B member 1
- Previous symbol:
- GLC3A
- Synonyms:
- CP1B
- Chromosome:
- 2p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-20
- Date modifiied:
- 2015-12-09
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- Cytochrome P450 1B1 (CYP1B1) is selectively overexpressed in various tumor cells and plays a critical role in the metabolic inactivation of chemotherapeutic agents, leading to drug resistance. Therefore, the development of selective CYP1B1 inhibitors represents a promising strategy to overcome chemoresistance. In this study, we designed and synthesized 19 novel trans-stilbene derivatives by introducing fluorine atoms or fluorinated side chains, aiming to potentially enhance drug metabolic stability and binding affinity. Among them, compounds 4h and 4i exhibited the most potent inhibitory activity against CYP1B1, with ICvalues of 6.5 ± 0.9 nM and 5.4 ± 0.5 nM, respectively, and demonstrated high selectivity within the CYP1 family over CYP1A1 and CYP1A2. In A549 cell models, both compounds significantly reversed DMBA-induced PTX resistance in a concentration-dependent manner. Furthermore, fluorescence staining revealed that compound 4i preferentially bound to CYP1B1-overexpressing tumor cells, including A549, HeLa, MCF-7, and HCT-15 cells, but not to non-cancerous 293T cells. These findings highlight the potential of fluorinated trans-stilbene derivatives as promising CYP1B1-targeted therapeutics for combating drug-resistant cancers. - Source: PubMed
Publication date: 2026/09/02
Yang MeixianLiu XinWei XinQiu DachuanChen WeijuanCai Jiajing - Lung ischemia-reperfusion injury (LIRI) is a serious complication of lung transplantation that causes respiratory distress and is associated with high mortality. Ferroptosis, a novel form of programmed cell death, contributes to the pathogenesis of LIRI. The Aryl Hydrocarbon Receptor (AhR) is a ligand-activated transcription factor that regulates a variety of physiological functions. However, the role and mechanism of AhR in ferroptosis during LIRI after lung transplantation remain to be further investigated. - Source: PubMed
Publication date: 2026/08/27
Deng PengXu GuanghuaWan LiXu JianweiYao ZuhuanSun Quanchao - Neonatal-onset Aicardi-Goutières syndrome (AGS) is a rare monogenic type I interferonopathy that may mimic congenital infection and can present with severe multisystem inflammation. The distinction between primary hemophagocytic lymphohistiocytosis (HLH) and AGS-associated macrophage activation syndrome (MAS)-like hyperinflammation can be challenging in neonates. - Source: PubMed
Publication date: 2026/08/24
Konak MuratBozkurt BanuCeylaner GülayCüceoğlu Müşerref KasapÖzdemir Fatih Mehmet AkifKara BuketDuysak Osman SelçukUygun Saime Sündüs - To clarify the molecular and clinical characteristics of anterior-segment dysgenesis (ASD)/aniridia and microphthalmia/anophthalmia caused by monogenic variants. - Source: PubMed
Publication date: 2026/07/28
Nishina SachikoAnzai HazukiYoshida TomoyoKoyanagi YoshitoKamada SayakaKato KumikoTorii KaorukoHikoya AkikoKondo MineoSotozono ChieMatsubara KeikoFukami Maki - The presence of multiple rare Mendelian disorders in a single patient may mask clinical recognition when phenotypes overlap. We describe a patient with longstanding myotonia congenita due to a variant in whom an incidental discovery of severe hypocalcemia led to the diagnosis of -related pseudohypoparathyroidism (PHP). Exome reanalysis also identified an incidental homozygous pathogenic variant associated with autosomal recessive glaucoma. - Source: PubMed
Publication date: 2026/08/14
Mukhtar Noha NAlturki DeemaBenito AllianahAlghamdi BalgeesAlshehri AliAlzahrani Ali S