LEF1 EMSA Kit
- Known as:
- LEF1 EMSA Kit
- Catalog number:
- AY1203
- Product Quantity:
- 25 rxn
- Category:
- -
- Supplier:
- Panomics
- Gene target:
- LEF1 EMSA Kit
Related genes to: LEF1 EMSA Kit
- Gene:
- LEF1 NIH gene
- Name:
- lymphoid enhancer binding factor 1
- Previous symbol:
- -
- Synonyms:
- TCF1ALPHA, TCF10, TCF7L3
- Chromosome:
- 4q25
- Locus Type:
- gene with protein product
- Date approved:
- 1991-06-05
- Date modifiied:
- 2016-01-13
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- Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare, low-grade malignant epithelial tumor that may originate from embryonic multipotent stem cells. The prevalence of metastatic SPN is approximately 9% to 15%, most commonly in the liver and peritoneum. Delayed ovarian metastasis during pregnancy is exceedingly rare, pregnancy may promote the progression and pose a life-threatening risk. - Source: PubMed
Publication date: 2026/04/11
Jie RuixiaDai XiaominLei HuanPeng Fang - The differences in egg production performance among hens are closely linked to the efficiency of follicle selection, which is characterized by granulosa cell differentiation and progesterone production. In this study, by integrating ATAC-seq and mRNA-seq analyses on granulosa cells from pre-hierarchical (Pre-GCs) and hierarchical (Post-GCs) follicles, we set out to identify key regulatory factors involved in chicken follicle selection. - Source: PubMed
Publication date: 2026/04/17
Li DandanQi ChaoSun YiKang LiWei QingqingJiang Yunliang - Tooth development or odontogenesis is a complex morphogenetic process that requires tightly regulated interactions between the oral epithelium and mesenchyme of neural crest origin. In this narrative review, we compile existing knowledge regarding gene regulatory networks and epigenetic factors throughout tooth development from initiation to eruption. Signaling between the epithelium and mesenchyme is mediated by four conserved pathways-Wnt/β-catenin, bone morphogenetic protein (BMP), fibroblast growth factor (FGF), and Sonic hedgehog (Shh)-which operate iteratively and interact through extensive crosstalk at each developmental stage. Transcription factors, such as PAX9, MSX1, PITX2, and LEF1, interpret these signals to control cell fate decisions and differentiation. Epigenetic modifications, including DNA methylation, histone modifications, and microRNA-mediated regulation, provide additional layers of control that fine-tune gene expression programs. Unlike existing reviews that address these regulatory mechanisms separately, here we integrate signaling pathways, transcription factor networks, epigenetic regulation, human genetic disorders, dental stem cell biology, and recent single-cell transcriptomic insights into a unified framework. We discuss opportunities to apply developmental biology knowledge towards regenerative dentistry goals, including iPSC-derived dental models and spatially resolved multi-omics approaches, while acknowledging the considerable gap between preclinical findings and clinical applications. - Source: PubMed
Publication date: 2026/03/30
Lee Dong-JoonWon Hyung-JinShin Jeong-Oh - 1. The correct development of follicles is essential for feather quality in geese, yet the role of in feather follicle formation during geese embryogenesis remains unclear.2. In this study, 140 Jilin White Goose () embryos were used as the experimental subjects. Feather follicle morphology at different developmental stages was examined using H&E staining and expression was assessed by RT-qPCR and Western blotting. Building on these observations, an injection experiment was performed at embryo day (ED)18 and an skin-culture system was established at ED23.3. The gene expression peaked at ED23, coinciding with a critical phase of feather follicle structural maturation. Following Stattic treatment, both STAT3 and phosphorylated STAT3 (p-STAT3) levels were markedly reduced, whereas the Wnt/β-catenin signalling genes and were up-regulated. This suggested that may function as a negative regulator of this pathway.4. The culture assay showed increased expression of and and reduced . This showed that gene inhibition promotes cell proliferation and suppresses apoptosis. These findings supported a regulatory role of in feather follicle development.5. The STAT3 gene serves as an important regulatory factor in feather follicle formation during goose embryonic development. - Source: PubMed
Publication date: 2026/04/13
Wang JPan HHu XZhang XZhou YWang YHou JYang ZLiu FSun Y - Molecular profiling is becoming crucial for accurate classification, prognostication, and therapeutic stratification for central nervous system (CNS) tumor classification since the advent of the WHO 2021 CNS tumor classification. However, in most of the low-income countries and middle-income countries, access to advanced molecular platforms remains limited due to cost, technical complexity, and turnaround time. Surrogate immunohistochemistry markers for mutation-specific or fusion-specific antibodies that reliably predict underlying genetic alterations offer a rapid, cost-effective alternative. The manuscript systematically discusses a spectrum of CNS tumor entities where morphology supplemented with immunohistochemistry can, in many cases, support an integrated molecular diagnosis, including "Astrocytoma, IDH-mutant" (IDH R132H, ATRX, and p53), "Oligodendroglioma, IDH-mutant, and 1p/19q codeleted" (HIP1R, H3K27me3 loss, and vimentin), "Diffuse midline glioma, H3K27-altered" (H3K27M, EZHIP), "Diffuse hemispheric glioma, H3G34-mutant" (H3G34R/V), "Infant-type hemispheric glioma" (Pan-TRK, ALK), "Epithelioid glioblastoma" and "Pleomorphic xanthoastrocytoma" (BRAF V600E)), "Astroblastoma, MN1-altered" (MN1), "Ependymoma" subtypes (p65, L1CAM, EZHIP), "Medulloblastoma" subgroups (β-catenin, LEF1, YAP1, GAB1), "Atypical teratoid/rhabdoid tumor" (SMARCB1, SMARCA4), "CNS neuroblastoma, FOXR2-activated" (FOXR2), "CNS tumor with BCOR ITD" (BCOR), and various sarcomas and sellar tumors (STAT6, NKX2.2, DUX4, β-catenin, BRAF V600E). For each entity, detailed morphologic features, immunoprofiles, sensitivity/specificity data, and diagnostic caveats have been described. The review emphasizes that when interpreted alongside histomorphology and conventional markers, surrogate immunohistochemistry can significantly reduce reliance on molecular testing, expedite diagnosis, and improve accessibility of precision diagnostics. Standardization, validation, and awareness of pitfalls remain essential to maximizing their clinical utility in neuropathology practice. - Source: PubMed
Publication date: 2026/04/09
Das SumantaSuri VaishaliAhlawat SunitaSharma Mehar C