HOXD9 _ HOXD10 EMSA Probe Set
- Known as:
- HOXD9 _ HOXD10 EMSA Probe Set
- Catalog number:
- AY1197P
- Product Quantity:
- 25 rxn
- Category:
- -
- Supplier:
- Panomics
- Gene target:
- HOXD9 _ HOXD10 EMSA Probe Set
Related genes to: HOXD9 _ HOXD10 EMSA Probe Set
- Gene:
- HOXD9 NIH gene
- Name:
- homeobox D9
- Previous symbol:
- HOX4C, HOX4
- Synonyms:
- -
- Chromosome:
- 2q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-15
- Date modifiied:
- 2015-08-25
- Gene:
- HOXD10 NIH gene
- Name:
- homeobox D10
- Previous symbol:
- HOX4, HOX4D
- Synonyms:
- -
- Chromosome:
- 2q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-15
- Date modifiied:
- 2019-04-23
Related products to: HOXD9 _ HOXD10 EMSA Probe Set
(+) Control probe (DNA), biotinylated(+) Control probe (RNA), biotinylated(-) Control probe (DNA), biotinylated(-) Control probe (RNA), biotinylated0.2 mm, 30 cm Spacer Set
0.2 mm, 30 cm Spacer Set0.35 mm, 30 cm Spacer Set
0.35 mm, 30 cm Spacer Set0.5 mm, 30 cm Spacer Set
0.5 mm, 30 cm Spacer Set0.75 mm Dual Gel Cast Set
0.75 mm Dual Gel Cast Set0.75 mm Plate Set, RM
0.75 mm Plate Set, RM
0.75 mm Plate Set, RM
Related articles to: HOXD9 _ HOXD10 EMSA Probe Set
- Fluoroquinolone antibiotics (FQs) play a crucial role in human and animal medicine, but their increasing use and high persistence have posed serious threats to ecosystems and public health. FQs have been found to be associated with heart developmental defects. However, the intergenerational effects of FQs on fish cardiac development remain poorly understood. Here we investigated the chronic effects of maternal exposure to environmentally related concentrations of norfloxacin (NOR) on cardiac development in zebrafish offspring. Our results showed that maternal NOR exposure resulted in increased mortality and malformation rates, impaired cardiac function and changes in cardiac phenotype, including larger cardiac looping angles, longer ventricular and increased distance between sinus venosus and bulbus arteriosus (SV-BA distance) in zebrafish offspring. Expression of genes involved in early cardiac development (myl7, vmhc, gata4, tbx1, tbx5, and nkx2.5) showed disorder. Maternal NOR exposure impairs cardiac looping by altering transcription levels of non-canonical WNT/PCP pathway genes (wnt11, fzd7a, and vangl2). Additionally, offspring of zebrafish following maternal NOR exposure showed increase in oxidative stress and apoptotic level. Meanwhile, genes associated with histone methylation (kdm6a, kdm6b, hoxd11a, hoxd9, and hoxd10) were up-regulated. Taken together, our results suggest that maternal NOR exposure cause cardiotoxicity in zebrafish offspring, possibly through inducing oxidative stress, promoting apoptosis, and regulating genes expression involved in cardiac development. We speculate that the intergenerational mechanisms of NOR action are likely to be related with histone modifications. Our study provides new insights into the potential risks and mechanisms underlying cardiotoxicity in fish offspring following maternal exposure to NOR. - Source: PubMed
Publication date: 2025/06/30
Bian ChongqianXun ZhaoboFu YiyangWang ZilongWang JijiaWu Lang - Glioblastoma is an aggressive cancer that affects the brain. The Homeobox B and D (HOXB/D) family has been linked to tumor progression, but their exact mechanism remains unclear. - Source: PubMed
Publication date: 2025/04/07
Ahmadi MohsenBazrgar MaryamAkhavan SaeedehFathi MohadesehMousavi PegahGhafouri-Fard Soudeh - In humans and rats, aging is associated with a progressive deterioration of spatial learning and memory. These functional alterations are correlated with morphological and molecular changes in the hippocampus. Here, we assessed age-related changes in DNA methylation (DNAm) landscape in the rat hippocampus and the correlation of spatial memory with hippocampal DNAm age in 2.6- and 26.6-month-old rats. Spatial memory performance was assessed with the Barnes maze test. To evaluate learning ability and spatial memory retention, we assessed the time spent by animals in goal sector 1 (GS1) and 3 (GS3) when the escape box was removed. The rat pan-tissue clock was applied to DNAm data from hippocampal tissue. An enrichment pathway analysis revealed that neuron fate commitment, brain development, and central nervous system development were processes whose underlying genes were enriched in hypermethylated CpGs in the old rats. In the old rat hippocampi, the methylation levels of CpG proximal to transcription factors associated with genes Pax5, Lbx1, Nr2f2, Hnf1b, Zic1, Zic4, Hoxd9; Hoxd10, Gli3, Gsx1 and Lmx1b, and Nipbl showed a significant regression with spatial memory performance. Regression analysis of different memory performance indices with hippocampal DNAm age was significant. These results suggest that age-related hypermethylation of transcription factors related to certain gene families, such as Zic and Gli, may play a causal role in the decline in spatial memory in old rats. Hippocampal DNAm age seems to be a reliable index of spatial memory performance in young and old rats. - Source: PubMed
Chiavellini PriscilaLehmann MarianneCanatelli Mallat MartinaZoller Joseph AHerenu Claudia BMorel Gustavo RHorvath SteveGoya Rodolfo G - Microvascular invasion (MVI) adversely affects postoperative long-term survival outcomes in patients with hepatocellular carcinoma (HCC). There is no study addressing genetic changes in HCC patients with MVI. We first screened differentially expressed genes (DEGs) in patients with and without MVI based on TCGA data, established a prediction model and explored the prognostic value of DEGs for HCC patients with MVI. - Source: PubMed
Publication date: 2021/12/16
Wang JinDing Zhi-WenChen KuangLiu Yan-ZheLi NanHu Ming-Gen - HOXD10 is a tumor modulator that can either be a tumor-suppressor or a tumor-promoting gene. However, the role of HOXD10 in glioblastoma multiforme (GBM) remains unclear. - Source: PubMed
Publication date: 2021/10/27
Li YanxinMa KeXie QiZhang XianweiZhang XiuleiChen KuiKong LingfeiQian Rongjun