Pax8 EMSA Probe Set
- Known as:
- Pax8 EMSA Probe Set
- Catalog number:
- AY1139P
- Product Quantity:
- 25 rxn
- Category:
- -
- Supplier:
- Panomics
- Gene target:
- Pax8 EMSA Probe Set
Related genes to: Pax8 EMSA Probe Set
- Gene:
- PAX8 NIH gene
- Name:
- paired box 8
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-11-16
- Date modifiied:
- 2017-07-07
Related products to: Pax8 EMSA Probe Set
(+) Control probe (DNA), biotinylated(+) Control probe (RNA), biotinylated(-) Control probe (DNA), biotinylated(-) Control probe (RNA), biotinylated0.2 mm, 30 cm Spacer Set
0.2 mm, 30 cm Spacer Set0.35 mm, 30 cm Spacer Set
0.35 mm, 30 cm Spacer Set0.5 mm, 30 cm Spacer Set
0.5 mm, 30 cm Spacer Set0.75 mm Dual Gel Cast Set
0.75 mm Dual Gel Cast Set0.75 mm Plate Set, RM
0.75 mm Plate Set, RM
0.75 mm Plate Set, RM
Related articles to: Pax8 EMSA Probe Set
- Mesonephric-like adenocarcinoma (MLA) is a rare gynecologic cancer, and primary involvement in the fallopian tube is extremely uncommon. We report a case of fallopian tube MLA with detailed peritoneal fluid cytology findings and a comparison of conventional smear and liquid-based cytology preparations. A 57-year-old woman presented with pelvic pain and ascites. Histopathologic examination confirmed stage IIIC MLA of the fallopian tube. Peritoneal fluid cytology, using both conventional smears and liquid-based cytology, showed moderate to high cellularity, with three-dimensional clusters exhibiting tubular, cribriform, papillary, and solid architectural patterns. The tumor cells were relatively uniform, and occasional cribriform structures were observed. Histologically, the tumor exhibited predominantly tubular and solid growth patterns, with focal areas resembling mesonephric tubules. The tumor cells showed focal elongated nuclei with overlapping nuclear grooves, resembling papillary thyroid carcinoma-like nuclear features characteristic of MLA. Immunohistochemically, the tumor cells demonstrated diffuse nuclear positivity for GATA3 and TTF-1, with widespread PAX8 expression. This case demonstrates that peritoneal fluid cytology can closely reflect the histologic heterogeneity of MLA and emphasizes the importance of correlating cytologic architectural features with immunohistochemical findings, particularly in this extremely rare entity. - Source: PubMed
Publication date: 2026/04/30
Toyoda ShinjiMorita KoheiSado Toshiyuki - Iodine is crucial for growth and development. Given that persistent iodine imbalance impairs thyroid function and can trigger various pathologies, this study preliminarily investigated the effects and underlying mechanisms of long-term iodine deficiency or excess on thyroid proliferation in rats. We established rat models of iodine deficiency and excess through long-term intervention with a low-iodine diet and deionized water containing different concentrations of potassium iodide. Our results revealed distinct molecular profiles under these conditions: iodine deficiency significantly upregulated the expression of TSHR and PKA-cat, whereas long-term iodine excess markedly suppressed them. Despite these divergent signaling initiations, both conditions resulted in a significant increase in the protein expression of PCNA and Pax8, unequivocally indicating enhanced thyroid follicular cell proliferation. Furthermore, key nodes of the Ras/MAPK pathway, RAS and BRAF, demonstrated a clear upward trend in the late intervention phase in both groups. These findings collectively demonstrate that both iodine deficiency and excess can promote thyroid proliferation; however, the mechanisms involved in driving this proliferative response are likely distinct. Deficiency acts by activating the TSH-TSHR-PKA pathway and synergistically enhancing RAS/BRAF signaling. In contrast, long-term iodine excess promotes thyroid proliferation by enhancing RAS/BRAF activation through inhibition of the TSHR-PKA axis. - Source: PubMed
Publication date: 2026/05/01
Cheng JunshuaiGao ZifanZhao YuanSong QiuyiWang YuXu TingtingLv KaiLi YanleiZhang WanqiLiu JuanTan Long - Renal-pelvic fibroepithelial polyps (FEPs) are rare benign mesodermal lesions that can radiologically and clinically mimic urothelial carcinoma, sometimes prompting radical surgery. We reviewed five consultation cases of renal pelvis or proximal-ureter FEPs, integrating histology, immunohistochemistry, and targeted molecular testing. Patients were all females, tumors measured 3.3-9.0 cm (mean 5.2 cm), and four arose in the renal pelvis with variable ureteral extension. Three patients underwent nephroureterectomy for presumed malignancy. Histologically lesions shared a polypoid architecture with fibrovascular cores lined by benign -appearing urothelium; stromal cellularity separated lesions into hypercellular (patients 1-2) and hypocellular stromal patterns. Hypocellular lesions displayed fibrocollagenous stroma with bland spindle cells and were lined by benign urothelium. Hypercellular examples showed epithelioid smooth muscle type or primitiveappearing-stromal proliferations with occasional mitoses and focal Ki-67 elevation but lacked significant atypia, necrosis, infiltrative growth, or lymphovascular invasion. Immunoprofiles confirmed urothelial epithelial differentiation (AE1/AE3, GATA3, PAX8) with areas of anastomosing cords and pyelitis cystica and variable stromal labeling for desmin, CD10, ER, and PR; myogenin/MyoD1 were negative. A fusion/cancer gene- NGS panel (including GLI1 and NCOA1/2) was negative in the tested case. No recurrences were observed with mean followup of 24 months. We emphasize distinguishing features from papillary urothelial carcinoma, mixed -epithelialstromal tumor/smooth muscle adenoma-like renal tumor (SMART), rhabdomyosarcoma, and -translocation associated mesenchymal neoplasms, noting that focal -fibroadenoma like- stromal areas can occur in FEPs. Recognition of the confined polypoid growth beneath intact urothelium, bland cytology, supportive immunohistochemistry, and selective molecular testing when stromal atypia raises concern, can avoid misclassification and unnecessary radical surgery. - Source: PubMed
Publication date: 2026/04/28
Zhang Guan-NanEugene Henrietta CArgani PedramBaraban Ezra GGross John MMatoso Andres - Atrial and brain natriuretic peptides activate GC-A/NPRA (guanylyl cyclase-A/natriuretic peptide receptor-A) and regulate blood pressure and electrolyte homeostasis. Renal tubule (RT) dysfunction results in decreased kidney function and increased blood pressure. We determined the sex-specific consequences of RT cell-specific deletion of (encoding NPRA) on blood pressure and renal hemodynamics. - Source: PubMed
Publication date: 2026/04/30
Neelamegam KandasamyRamasamy ChandramohanSamivel RamachandranHao ShoujinFerreri Nicholas RDong ZhengXia HuijingKapusta Daniel RPandey Kailash N - Renal angiomyolipomas (AMLs) are rare benign kidney tumors. Epithelioid angiomyolipoma (EAML) is a distinct variant with unique histopathological features and recognized malignant potential. This study highlights the diagnostic features and pitfalls of EAML. A 41-year-old woman was referred after an incidental left renal mass was detected on ultrasound. She was asymptomatic, with unremarkable examination and laboratory results, though her family history included several malignancies. Magnetic resonance imaging revealed a 3.5-cm partly exophytic, posterior lower-pole renal mass without pelvicalyceal invasion. The patient underwent robotic-assisted left partial nephrectomy. Histopathology showed a tumor composed predominantly of epithelioid cells with reduced vascularity, thick-walled vessels, and adipose tissue. Immunohistochemistry demonstrated positivity for smooth muscle actin (SMA) and Human Melanoma Black-45 (HMB-45) and negativity for Paired box 8 (PAX-8), confirming EAML. EAML poses diagnostic and management challenges due to uncertain malignant potential and lack of guidelines. Surgical resection remains primary treatment, with long-term surveillance recommended. - Source: PubMed
Publication date: 2026/04/28
AbuHaweeleh Mohannad NAlhyari AbdelkareemGoyal RajenKhalil Ibrahim ABadawi AlaeddinAl-Rumaihi Khalid