GATA3 EMSA Kit
- Known as:
- GATA3 EMSA Kit
- Catalog number:
- AY1096
- Product Quantity:
- 25 rxn
- Category:
- -
- Supplier:
- Panomics
- Gene target:
- GATA3 EMSA Kit
Related genes to: GATA3 EMSA Kit
- Gene:
- GATA3 NIH gene
- Name:
- GATA binding protein 3
- Previous symbol:
- -
- Synonyms:
- HDR
- Chromosome:
- 10p14
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-03
- Date modifiied:
- 2016-10-05
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- Breast metastases from extramammary malignancies are rare, and those originating from renal cell carcinoma (RCC) are exceptionally uncommon. These lesions often follow an indolent course, delaying recognition until acute, life-threatening complications such as hemorrhagic rupture occur. The lack of standardized management guidelines further impedes timely intervention. - Source: PubMed
Publication date: 2026/08/11
Huang ChengminWang YaqiZhou QiufengJin Qiuchao - The formation of the blastocyst is a highly orchestrated process involving different cellular and molecular aspects. In mice, the mTOR pathway influences the Hippo pathway, leading to expression of trophectoderm (TE)-related genes. However, these mechanisms are not fully characterized in bovine embryos, and biological pathways are not always conserved across species. We hypothesized that mTOR pathway positively influences the TE differentiation in bovine embryos. This study aimed to evaluate the effects of the mTOR agonist MHY1485 (MHY) on TE formation in in vitro-produced bovine embryos. Embryos were treated at 96 h post insemination (hpi) with 2 µM MHY or DMSO (vehicle) until 144 hpi or 192hpi. At 144 hpi, morulae were collected for gene expression analysis of CDX2, GATA3, OCT4, SOX2, TFAP2C and YAP1. No significant differences in mRNA expression were observed between the Control, DMSO or MHY groups. At 192 hpi, embryos were fixed for confocal microscopy to assess the TE marker GATA3 and the Hippo-related transcription factor YAP1. While total cell and inner cell mass counts remained unaffected, TE cell numbers were significantly reduced in the DMSO group compared to both the Control and MHY groups. Furthermore, nuclear YAP1 intensity was lower in the DMSO group compared to the MHY group, in which YAP1 was lower than the Control. In conclusion, pharmacological activation of the mTOR pathway did not positively influence TE differentiation in bovine embryos; however, it effectively rescued the unexpected negative effects induced by the vehicle (DMSO) on TE cell number and YAP1 signaling. - Source: PubMed
Publication date: 2026/08/25
Vilioti Mirela SoaresRagnelli Beatriz CartaxoBerling Francieli PerroniMendes Camilla MotaAssumpção Mayra Elena Ortiz D'ÁvilaGoissis Marcelo Demarchi - To characterize the clinicopathological spectrum of solid papillary carcinoma (SPC) in our institutional cohort and to attempt to interpret unusual findings observed during routine diagnostic workup. - Source: PubMed
Publication date: 2026/08/22
Hu BingrongWang TingtingYu JunYan Wentian - Radiation-induced pulmonary fibrosis, a devastating thoracic radiotherapy sequela, features aberrant ECM deposition and irreversible loss of functional lung architecture. However, the exact molecular mechanisms governing AECII dysfunction and fate transition during RIPF remain poorly understood. Here, we identify a novel metabolic-epigenetic-epitranscriptomic cascade that orchestrates the pro-fibrotic fate of AECIIs. We demonstrate that radiation exposure triggers a glycolytic shift in AECIIs, resulting in pathological intracellular lactate accumulation. This metabolic stress is directly coupled to chromatin remodeling via p300-mediated H3K18la at the VIRMA promoter, driving its robust transcriptional activation. Consequently, elevated VIRMA promotes a pro-fibrotic epitranscriptomic landscape by increasing m6A enrichment on the GATA3 mRNA. Recognition of this modification by the m6A reader YTHDF1 extends GATA3 mRNA half-life. The ensuing GATA3 accumulation initiates EMT and exacerbates ECM deposition. Strikingly, utilizing AECII-specific Virma conditional knockout mice, we confirmed the essential role of this axis in vivo; genetic ablation of Virma preserved alveolar integrity and conferred resistance to radiation-induced fibrogenesis. Furthermore, pharmacological inhibition of the H3K18la writer p300 using C646 abrogated the fibrotic phenotype. Collectively, our findings elucidate how radiation-induced metabolic reprogramming is durably inscribed into the epigenome to dictate cell fate, offering a therapeutic rationale for targeting the H3K18la/VIRMA/GATA3 axis in RIPF. - Source: PubMed
Publication date: 2026/08/24
Yi JunxuanWang MingweiYu DuoZhao MingqiWang XinyanLi ShiqiHan XiaowenWei WeiJin Shunzi - Data on molecular sub-typing of bladder cancer (BC) associated with heavy metals (HMTE) are lacking. Clinical significance of luminal (GATA3) and basal (cytokeratin 5/6) markers in BC is controversial. Therefore, objective is to use these markers to characterize BC associated with HMTE into luminal and basal, and to investigate their clinical significance. - Source: PubMed
Publication date: 2026/08/20
Ali-El-Dein BedeirAbdelgawad MahmoudAbdel-Rahim MonaGomaa Islam MElnaggar Islam IZahran FatenSalama Afrah FKeshta Akaber TMohamed Amro ESaleh Hazem HMortada Wael IAttia Afaf MElkady Manar E